A5100327339- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Neurosurgical Procedures and Complications
- Cancer, Hypoxia, and Metabolism
- Periodontal Regeneration and Treatments
- Aortic aneurysm repair treatments
- Radiomics and Machine Learning in Medical Imaging
- Mesenchymal stem cell research
- Neurological Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Sarcoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Advanced X-ray and CT Imaging
- Meningioma and schwannoma management
- Autophagy in Disease and Therapy
Hospital of Hebei Province
2025
Nanjing University
2016-2025
Nanjing General Hospital of Nanjing Military Command
2016-2025
Southern Medical University
2016-2025
Nanjing Medical University
2014-2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Shanghai Tenth People's Hospital
2025
Tongji University
2021-2025
Peking University Third Hospital
2013-2024
Abstract Intracranial aneurysm is a common life-threatening disease. Computed tomography angiography recommended as the standard diagnosis tool; yet, interpretation can be time-consuming and challenging. We present specific deep-learning-based model trained on 1,177 digital subtraction verified bone-removal computed cases. The has good tolerance to image quality tested with different manufacturers. Simulated real-world studies are conducted in consecutive internal external cohorts, which it...
Abstract Osteochondral regeneration remains a great challenge due to the limited self‐healing ability and complexity of its hierarchical structure composition. Mg 2+ hypoxia are two effective modulators in boosting chondrogenesis. To this end, double‐layered scaffold (D) consisting hydrogel layer on porous cryogel is fabricated mimic osteochondral tissue. An gradient incorporated into with hypoxia‐mimicking deferoxamine (DFO) embedded (D‐Mg‐DFO), which remarkably augments dual‐lineage both...
The regeneration of osteochondral tissue necessitates the re-establishment a gradient owing to unique characteristics and healing potential chondral osseous phases. As self-healing capacity hyaline cartilage is limited, timely mechanical support during neo-cartilage formation crucial achieving optimal repair efficacy. In this study, we devised biodegradable bilayered scaffold, comprising chondroitin sulfate (CS) hydrogel regenerate porous pure zinc (Zn) scaffold for underlying bone as layer....
Osteoarthritis (OA) is a prevalent disease, characterized by subchondral fractures in its initial stages, which has no precise and specific treatment now. Here, novel multifunctional scaffold synthesized photopolymerizing glycidyl methacrylate-modified hyaluronic acid (GMHA) as the matrix presence of hollow porous magnetic microspheres based on hydroxyapatite. In vivo bone repairing results demonstrate that scaffold's meticulous design most suitable properties for repair. The structure...
Astaxanthin (ATX) has been proven to ameliorate early brain injury (EBI) after experimental subarachnoid hemorrhage (SAH) by modulating cerebral oxidative stress. This study was performed assess the effect of ATX on Nrf2-ARE pathway and explore underlying molecular mechanisms antioxidant properties in EBI SAH. A total 96 male SD rats were randomly divided into four groups. Autologous blood injected prechiasmatic cistern rat induce an SAH model. Rats each group sacrificed at 24 h Expressions...
Abstract Increasing evidence indicates that sirtuin 1 (SIRT1) is implicated in a wide range of cellular functions, such as oxidative stress, inflammation and apoptosis. The aim this study was to investigate the change SIRT1 brain after subarachnoid hemorrhage (SAH) its role on SAH-induced early injury (EBI). In first set experiments, rats were randomly divided into sham group SAH groups at 2, 6, 12, 24, 48 72 h. expression evaluated by western blot analysis, immunohistochemistry...
OBJECT.: Aneurysmal subarachnoid hemorrhage (SAH) causes devastating rates of mortality and morbidity. Accumulating studies indicate that early brain injury (EBI) greatly contributes to poor outcomes after SAH oxidative stress plays an important role in the development EBI following SAH. Astaxanthin (ATX), one most common carotenoids, has a powerful antioxidative property. However, potential ATX protecting against remains obscure. The goal this study was assess whether can attenuate...
Previous studies have demonstrated resveratrol (RSV) has beneficial effects in early brain injury (EBI) after subarachnoid hemorrhage (SAH). However, the of RSV and underlying mechanisms not been clearly identified. The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation plays a crucial role EBI pathogenesis. aim this study was to investigate on NLRP3 signaling pathway rats SAH. A prechiasmatic cistern injection model...
Abstract Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent melanoma 2 (AIM2) inflammasome is primarily found neurons, highly specific and can be activated only by double-stranded DNA. Although it has demonstrated that AIM2 poly(deoxyadenylic-deoxythymidylic) acid sodium salt leads to pyroptotic neuronal cell death, role inflammasome-mediated pyroptosis early brain injury (EBI) after subarachnoid haemorrhage (SAH) rarely studied....
Abstract: Objective: Tacrolimus is an immunosuppressive drug with a narrow therapeutic range and wide interindividual variation in its pharmacokinetics. Cytochrome P450 (CYP) 3A P‐glycoprotein (P‐gp, encoded by MDR1) play important role the absorption metabolism of tacrolimus. The objective this study was to evaluate whether or not CYP3A5*1/*3 MDR1 C3435T polymorphisms are associated tacrolimus concentration per dose. Methods: CYP3A5 genotypes were determined polymerase chain reaction...
Abstract Introduction Extracellular matrix (ECM) degradation leads to malfunction of the cartilage in osteoarthritis (OA). Inflammatory cytokine interleukin-1 beta (IL-1β) functions ECM and prevents synthesis by down-regulating key transcription factor, Sox9 , consequently inhibiting gene expression. Evidence reveals that microRNAs (miRNA) have been associated with OA, but little is known their function chondrocyte degradation. This study aimed identify possible miRNAs mediate IL-1β-induced...
Injectable, in situ forming hydrogels have exhibited many advantages regenerative medicine. Herein, we present the novel design of poly(l-glutamic acid) injectable via self-crosslinking adipic dihydrazide (ADH)-modified (PLGA-ADH) and aldehyde-modified (PLGA-CHO), investigate their potential cartilage tissue engineering. Both hydrazide modification degree PLGA-ADH oxidation PLGA-CHO can be adjusted by amount activators sodium periodate, respectively. Experiments reveal that solid content...
Inflammation plays a key role in the progression of subarachnoid hemorrhage (SAH). Here, we examined effects astaxanthin (ATX) on inflammatory response and secondary damage after SAH underlying mechanisms action. In vivo, prechiasmatic cistern injection model was established rats mice. addition, neuron-microglia cocultures were exposed to oxyhemoglobin mimic vitro. Western blotting revealed that protein expression TLR4 markedly increased microglia at 24 h SAH, with consequent increases...
Toll-like receptor 4 (TLR4) has been proven to play a critical role in neuroinflammation and represent an important therapeutic target following subarachnoid hemorrhage (SAH). Resveratrol (RSV), natural occurring polyphenolic compound, powerful anti-inflammatory property. However, the underlying molecular mechanisms of RSV protecting against early brain injury (EBI) after SAH remain obscure. The purpose this study was investigate effects on TLR4-related inflammatory signaling pathway EBI...
Apoptosis has been proven to play a crucial role in early brain injury pathogenesis and represent target for the treatment of subarachnoid hemorrhage (SAH). Previously, we demonstrated that astaxanthin (ATX) administration markedly reduced neuronal apoptosis period after SAH. However, underlying molecular mechanisms remain obscure. In present study, tried investigate whether ATX is associated with phosphatidylinositol 3-kinase-Akt (PI3K/Akt) pathway, which can an important signaling...
Atherosclerosis is a chronic inflammatory disease and the major pathological factor of most cardiovascular diseases, leading to ≈1/3 deaths worldwide. Improving local delivery anti-inflammatory drugs site atherosclerosis has significant promise prevent development atherosclerotic plaque clinically. Here, modified-macrophage-membrane-coated nanoparticle drug able transport colchicine reported. This hybrid system efficiently targets endothelial cells under an environment while escaping...
Osteoarthritis is a serious disease affecting joint cartilage. Owing to poor blood supply, the meniscus and acetabular labrum of joints heal poorly after injury. However, development artificial alternatives these components that have similar mechanical properties cartilage-protection ability challenging. In this study, strong hydrogel with biomimetic microstructure prepared an emulsion-type photosensitive resin, where both hydrophilic hydrophobic monomers, photo-initiator, drugs can be...
Hydrogels are attractive for cartilage tissue engineering because of their high plasticity and similarity with the native matrix. However, one critical drawback hydrogels osteochondral repair is inadequate mechanical strength. To address this limitation, we constructed a solid-supported thermogel comprising chitosan hydrogel system demineralized bone Scanning electron microscopy, equilibrium scanning ratio, biodegradation rate, biomechanical tests, biochemical assays, metabolic activity...