Injectable hydrogels as an important biomaterial class have been widely used in regenerative medicine. A series of injectable poly(l-glutamic acid)/alginate (PLGA/ALG) were fabricated by self-cross-linking hydrazide-modified acid) (PLGA-ADH) and aldehyde-modified alginate (ALG-CHO). Both the degree PLGA modification oxidation ALG-CHO could be adjusted amount activators sodium periodate, respectively. The effect solid content on gelation time, equilibrium swelling, mechanical properties,...

Self-healing polymeric hydrogels have the capability to recover their structures and functionalities upon injury, which are extremely attractive in emerging biomedical applications. This research reports a new kind of self-healing polypeptide based on self-assembly between cholesterol (Chol)-modified triblock poly(L-glutamic acid)-block-poly(ethylene glycol)-block-poly(L-glutamic acid) ((PLGA-b-PEG-b-PLGA)-g-Chol) β-cyclodextrin (β-CD)-modified (PLGA-g-β-CD). The hydrogel formation relied...

Chitosan (CS) hydrogels are widely used in wound hemostatic agents due to their superior biocompatibility, biodegradability, and effect. However, most of them fail achieve great effect because poor adhesion bleeding tissues. Also, the conventional implantation surgery internal wounds may cause secondary trauma human body. In this work, catechol-hydroxybutyl chitosan (HBCS-C) has been designed prepared by grafting hydroxybutyl groups catechol CS backbones. The multifunctional HBCS-C...

Injectable hydrogels have received much attention because of the advantages simulation natural extracellular matrix, microinvasive implantation, and filling repairing complex shape defects. Yet, for bone repair, current injectable shown significant limitations such as lack tissue adhesion, deficiency self-healing ability, absence osteogenic activity. Herein, a strategy to construct mussel-inspired bisphosphonated nanocomposite with adhesive, self-healing, properties is developed. The...

High levels of reactive oxygen species (ROS) and hypoxia in diabetic wounds significantly hinder the healing process. In this work, a kind catalase-like nanozyme-hybrid hydrogel was developed to explore potential harnessing endogenous excessive ROS as an source synergistically regulate oxidative stress hypoxia, thereby enhancing wound healing. The hydrogels exhibited rapid degradation controlled release ferrihydrite nanozymes response stress, which continuously catalyzed decomposition H2O2...

Injectable, in situ forming hydrogels have exhibited many advantages regenerative medicine. Herein, we present the novel design of poly(l-glutamic acid) injectable via self-crosslinking adipic dihydrazide (ADH)-modified (PLGA-ADH) and aldehyde-modified (PLGA-CHO), investigate their potential cartilage tissue engineering. Both hydrazide modification degree PLGA-ADH oxidation PLGA-CHO can be adjusted by amount activators sodium periodate, respectively. Experiments reveal that solid content...

Abstract Articular cartilage tissue is incapable of self‐repair and therapies for defects are still lacking. Injectable hydrogels have drawn much attention in the field regeneration. Herein, novel design nanofiber composite microchannel‐containing inspired by tunnel‐piled structure subway tunnels proposed. Based on aldehydized polyethylene glycol/carboxymethyl chitosan (APA/CMCS) hydrogels, thermosensitive gelatin microrods (GMs) used as a pore‐forming agent, coaxial electrospinning...

Cartilage injury is a very common joint disease, and cartilage repair great challenge in clinical treatment due to the specific structure of tissue its microenvironment vivo. The injectable self-healing hydrogel promising candidate as material because special network structure, high water retention properties. In this work, cross-linked by host-guest interaction between cyclodextrin cholic acid was developed. host composed β-cyclodextrin 2-hydroxyethyl methacrylate-modified poly(l-glutamic...

Injectable hydrogels have drawn much attention in the field of tissue engineering because advantages such as simple operation, strong plasticity, and good biocompatibility biodegradability. Herein, we propose novel design injectable via a Schiff base cross-linking reaction between adipic dihydrazide (ADH)-modified poly(l-glutamic acid) (PLGA-ADH) benzaldehyde-terminated poly(ethylene glycol) (PEG-CHO). The effects mass fraction molar ratio −CHO/–NH2 on gelation time, mechanical properties,...

Abstract N,N ′‐Bis(benzoyl) suberic acid dihydrazide (NA) as nucleating agent for poly( L ‐lactic acid) (PLLA) was synthesized from benzoyl hydrazine and suberoyl chloride, which deprived via acylation. PLLA/NA samples were prepared by melt blending a hot‐press forming process. The nonisothermal isothermal crystallization, spherulite morphology, melting behavior of with different contents NA investigated differential scanning calorimetry, depolarized‐light intensity measurement, electron...

Porous scaffolds composed of polypeptides and polysaccharides have remarkable biocompatibility potential to mimic an extracellular matrix for tissue engineering. This study presented a novel design polyelectrolyte complex porous synthetic polypeptide poly(L-glutamic acid) (PLGA) natural polysaccharide chitosan (CS) using freeze drying method. The microstructure the could be adjusted by changing freezing temperature solid content reacting polymer. PLGA/CS fabricated from 2% at −20 °C...

Porous microcarriers have aroused increasing attention recently, which can create a protected environment for sufficient cell seeding density, facilitate oxygen and nutrient transfer, well support the attachment growth. In this study, porous fabricated from strontium-substituted hydroxyapatite-graft-poly(γ-benzyl-l-glutamate) (Sr10-HA-g-PBLG) hybrid nanocomposite were developed. The surface grating of PBLG, micromorphology element distribution, mechanical strength, in vitro degradation, Sr2+...

Developing a tough, self-healing, and biodegradable composite hydrogel based on poly(<sc>l</sc>-glutamic acid) leads to great potential in tissue engineering applications.

Injectable hydrogels have shown great potential in bone tissue engineering. Simvastatin (SIM), a common hypolipidemic drug, has been suggested as agent to promote regeneration. However, due its hydrophobic nature, the compatibility between SIM and is rather poor, thereby greatly affecting drug release behavior, mechanical properties, dimensional stability of hydrogels. Herein, we presented novel design entrap an injectable maltodextrin-based micelle/hydrogel composite system....

Osteochondral tissue engineering is challenged by the difficulty in regeneration of hyaline cartilage and simultaneous subchondral bone. In present study, nhydroxyapatite-graft-poly(l-glutamic acid) (nHA-g-PLGA) was prepared surface-initiated ring-opening polymerization, which then used to fabricate an osteogenic scaffold (scaffold O) instead nHA achieve better mechanical performance. Then, a single osteochondral fabricated combining poly(l-glutamic (PLGA)/chitosan (CS) amide bonded hydrogel...