A5072294224- Bone Tissue Engineering Materials
- Magnesium Alloys: Properties and Applications
- Electrospun Nanofibers in Biomedical Applications
- Spine and Intervertebral Disc Pathology
- Wound Healing and Treatments
- Surface Modification and Superhydrophobicity
- Angiogenesis and VEGF in Cancer
- Sirtuins and Resveratrol in Medicine
- Inflammatory mediators and NSAID effects
- Spinal Fractures and Fixation Techniques
- Liver Disease Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Corrosion Behavior and Inhibition
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- MXene and MAX Phase Materials
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Peroxisome Proliferator-Activated Receptors
- Graphene and Nanomaterials Applications
- Polymer Surface Interaction Studies
- Bone health and treatments
- biodegradable polymer synthesis and properties
- Diabetic Foot Ulcer Assessment and Management
- Aluminum Alloys Composites Properties
Second Military Medical University
2014-2025
Shanghai Changzheng Hospital
2014-2024
Zhejiang Chinese Medical University
2022
Chinese People's Liberation Army
2014
Magnesium (Mg) and its alloys have emerged as a favored candidate for bio-regenerative medical implants due to their superior biocompatibility, biodegradability the elastic modulus close that of human bone. Unfortunately, rapid uncontrollable degradation rate Mg in chloride-rich body microenvironments limits clinical orthopedic applications. Recently, Calcium Phosphate (Ca-P) biomaterials, especially Hydroxyapatite (HA), been broadly applied surface functional modification metal-based...
Abstract The advancement of biomaterials with antimicrobial and wound healing properties continues to present challenges. Macrophages are recognized for their significant role in the repair infection-related wounds. However, interaction between macrophages remains complex requires further investigation. In this research, we propose a new sequential immunomodulation method enhance expedite by leveraging immune bacteria-related wounds, utilizing novel mixed hydrogel dressing. matrix is derived...
Post-surgical peritoneal adhesions constitute a classic problem in surgery, and thus anti-adhesion materials are much required. In this study, series of polyester-PEG-polyester triblock copolymers with different biodegradable polyester compositions were synthesized, their properties examined, the vivo efficacies as biomaterials evaluated comparative way for first time. These samples not only exhibited various morphologies bulk state, but also possessed stabilities sol state. All polymer...
It is a great challenge to prepare "functional artificial bone" for the repair of large segmental defect, especially in weight-bearing bones. In this study, bioactive HA/PCL composite scaffolds that possess anatomical structure as autogenous bone were fabricated by CT-guided fused deposition modeling technique. The can provide mechanical support and osteoconduction property. Then VEGF-165/BMP-2 loaded hydrogel was filled into biomimetic spatially introduce osteoinduction angioinduction...
Lack of vascularization is directly associated with refractory wound healing in diabetes mellitus (DM). Enrichment endothelial precursor cells (EPCs) a promising but challenging approach for the treatment diabetic wounds. Herein, we investigate action nicotinamide riboside (NR) on EPC function improved Db/db mice that were treated NR-supplemented food (400 mg/kg/d) 12 weeks exhibited higher rates and angiogenesis than untreated db/db mice. In agreement this phenotype, NR supplementation...
Aging is one of the risk factors non-alcoholic fatty liver disease (NAFLD). Yet, mechanism underlying aging-associated NAFLD-like syndrome not fully understood. Nicotinamide adenine dinucleotide (NAD), a ubiquitous coenzyme, has protective effects against aging. Here, we investigated actions NAD precursors nicotinamide riboside (NR) on development aging-induced NAFLD.NR supplemented food (2.5 g/kg food) was applied to aged mice for three months while normal chow other groups. Body weight,...