A5112104418- Electrochemical sensors and biosensors
- COVID-19 Clinical Research Studies
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Analytical Chemistry and Sensors
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Alzheimer's disease research and treatments
- Metabolism, Diabetes, and Cancer
- Acute Kidney Injury Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nuclear Receptors and Signaling
- Respiratory viral infections research
- Microtubule and mitosis dynamics
- Apelin-related biomedical research
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Renal and related cancers
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Genetics, Aging, and Longevity in Model Organisms
- Long-Term Effects of COVID-19
- Genomics, phytochemicals, and oxidative stress
Wuhan Third Hospital
2014-2025
Tongren Hospital
2019-2025
Wuhan No.1 Hospital
2016
Wuhan University
2016
National Taiwan University
2008
OBJECTIVE Diabetes is one of the most distinct comorbidities COVID-19. Here, we describe clinical characteristics and outcomes in patients with diabetes whom COVID-19 was confirmed or clinically diagnosed (with typical features on lung imaging symptoms) their association glucose-lowering blood pressure–lowering medications. RESEARCH DESIGN AND METHODS In this retrospective study involving 904 (136 diabetes, mostly type 2 diabetes), laboratory were collected compared between group without...
Protein misfolding and aggregation are associated with more than twenty diseases, such as neurodegenerative diseases metabolic diseases. The amyloid oligomers fibrils may induce cell membrane disruption lead to apoptosis. A great number of studies have focused on discovery inhibitors which prevent or treat amyloidosis Polyphenols been extensively studied a class inhibitors, several polyphenols under clinical trials anti-neurodegenerative drugs. As oxidative intermediates natural polyphenols,...
Abstract Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney molecule-1 (KIM1) is dramatically upregulated in renal tubules upon injury, acts as a biomarker for various diseases. However, the exact role underlying mechanism of KIM1 progression AKI remain elusive. Herein, we report that tubular specific knockout Kim1 attenuates cisplatin- or ischemia/reperfusion-induced male mice. Mechanistically, transcription factor Yin Yang 1 (YY1), which downregulated AKI, binds to...
Diabetic nephropathy is the primary cause of end-stage renal disease. Increasing numbers patients are suffering from this disease and therefore novel medications therapeutic approaches urgently needed. Here, we investigated whether apelin-13, most active member adipokine apelin group, could effectively suppress development in Akita mouse, a spontaneous type 1 diabetic model. Apelin-13 treatment decreased diabetes-induced glomerular filtration rate, proteinuria, hypertrophy, mesangial...
The aim of our study was to investigate the protective effects and underlying mechanisms myricetin, a bioactive food compound, on brain injury neurological deficits after ischemic stroke. Treatment myricetin significantly attenuated oxygen-glucose deprivation (OGD)-induced cell death in SHSY5Y cells vitro. In rat model cerebral ischemia, administered intragastrically at 2 h before every day middle artery occlusion (MCAO). were evaluated by various biochemical assays neurobehavioral tests....
Ischemia-reperfusion injury (I/R) is a common cause of acute kidney (AKI). Post-ischemic recovery renal blood supply plays an important role in attenuating injury. Exogenous application elabela (ELA) peptides has been demonstrated by us and others to alleviate AKI, partly through its receptor APJ. However, the endogenous ELA I/R remains unclear.
<div><b>OBJECTIVE:</b> Diabetes is one of the most distinct comorbidities COVID-19. Here, we described clinical characteristics and outcomes in diabetic patients with confirmed or clinically diagnosed (with typical lung imaging features symptoms) COVID-19, their association glucose lowering blood pressure medications.</div><div><br></div><div><b>RESEARCH DESIGN AND METHODS: </b>In this retrospective study involving 904 COVID-19 (136...
Rationale: Increased methylation of key genes has been observed in kidney diseases, suggesting that the ten-eleven translocation (Tet) methyl-cytosine dioxygenase family as well 5mC oxidation may play important roles. As a member Tet family, role Tet1 acute injury (AKI) remains unclear. Methods:Tet1 knockout mice, with or without tempol treatment, scavenger reactive oxygen species (ROS), were challenged ischemia and reperfusion (I/R) unilateral ureteral obstruction (UUO) injury....
MPHOSPH1 is a critical kinesin protein that functions in cytokinesis. Here, we show overexpressed hepatocellular carcinoma (HCC) cells, where it essential for proliferation. Attenuating expression with tumor-selective shRNA-expressing adenovirus (Ad-shMPP1) was sufficient to arrest HCC cell proliferation manner associated an accumulation of multinucleated polyploid induction postmitotic apoptosis, and increased sensitivity taxol cytotoxicity. Mechanistic investigations showed attenuation...
Proteins that bind to microtubule are important for cell cycle, and some of these proteins show oncogenic characteristics with mechanisms not fully understood. Herein we demonstrate overexpression protein regulator cytokinesis 1 (PRC1), a microtubule-associated mitosis, in human hepatocellular carcinoma (HCC). Moreover, upregulated PRC1 is associated lower survival rates HCC patients. Mechanistically, reducing blocks mitotic exit cells at telophase spindle assembly checkpoint independent...
Amyloid formation is associated with multiple amyloidosis diseases. Human calcitonin (hCT) a typical amyloidogenic peptide, its aggregation medullary carcinoma of the thyroid (MTC), and also limits clinical application. Magnolia officinalis traditional Chinese herbal medicine; two major polyphenol components, magnolol (Mag) honokiol (Hon), have displayed functions. Polyphenols like flavonoids their derivatives been extensively studied as amyloid inhibitors. However, anti-amyloidogenic...
Dopamine (DA) and serotonin (5-HT) are directly simultaneously determined in cerebrospinal fluid (CSF) by using MWNTs-SiO2-chitosan composites modified screen-printed electrode (SPE). Owing to the high catalytic activity of composites, is found exhibit a remarkably enhanced electro-activity toward sensing DA 5-HT. Under optimum experimental conditions, SPE could be used for determination 5-HT wide concentration ranges 1 μM~20 μM 0.1 μM~2 μM, respectively, whereas detection limits have been...
In this work, a novel and simple method for pharmacokinetic of theophylline in rats was described with modified sensor based on MWNTs/Au/poly-L-lysine.The screen-printed electrode exhibited excellent electrocatalytic activity towards the oxidation real biological samples.The optimum experimental conditions were explored by square wave voltammetry (SWV).The peak current proportional to concentration range 10 μM 200 detection limit 2.0 μM.Compared HPLC method, newly proposed also good results...
Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High-fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis. How HCC cells regulate ROS level escape the high fat diet (HFD) stress remains unclear. Herein, this work reports critical anti-ROS/apoptotic role ubiquitin-like protein interferon stimulated gene 15 (ISG15) HFD-promoted HCC. In mouse models clinical samples, upregulation...
Acute kidney injury (AKI) has high incidence and mortality rates. Present treatments are mostly symptomatic cause side effects due to systemic distribution; thus, targeted drug delivery is desired. Transmembrane molecule-1 (KIM1) expressed at low levels in normal kidneys but markedly up-regulated following injury, making it an ideal marker/target for injured kidneys. Here, assisted by AlphaFold, we constructed a library of 1885 peptides that target the extracellular Ig V domain KIM1 based on...
Nonsmall cell lung cancer (NSCLC) is highly malignant with limited treatment options, platinum-based chemotherapy a standard for NSCLC resistance commonly seen. cells exploit enhanced antioxidant defense system to counteract excessive reactive oxygen species (ROS), which contributes largely tumor progression and chemotherapy, yet the mechanisms are not fully understood. Recent studies have suggested involvement of histones in cellular response; however, whether major histone variant H1.2...
Abstract Kinesin family member 20B ( KIF 20B, also known as MPHOSPH 1) is a kinesin protein that plays critical role in cytokinesis. Previously, we and others have demonstrated the oncogenic of several cancers; however, exact mechanisms underlying its tumorigenic effects remain unclear. Herein, showed overexpression human hepatocellular carcinoma HCC ) reported negative correlation between level prognosis patients. Mechanistically, reducing blockades mitotic exit cells at telophase spindle...
Long-term hyperglycemia is a typical symptom of diabetes mellitus (DM) which can cause high level protein glycation and lead to the formation advanced end products (AGEs). The accumulation AGEs in turn deteriorates DM its complications. Insulin, only hormone that directly decreases blood sugar vivo, vulnerable causes loss biological activity. In this study, we used porcine insulin (PI)-methylglyoxal (MGO) model investigate inhibitory effect leonurine (LN), natural alkaloid extracted from...