Jiajian Shi

ORCID: 0009-0002-8052-8675
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Research Areas
  • Nuclear Materials and Properties
  • Malaria Research and Control
  • Fusion materials and technologies
  • Hepatitis B Virus Studies
  • Animal Virus Infections Studies
  • Thermodynamic and Structural Properties of Metals and Alloys
  • Viral gastroenteritis research and epidemiology
  • Nuclear reactor physics and engineering
  • Hydrogen embrittlement and corrosion behaviors in metals
  • High Temperature Alloys and Creep
  • Virus-based gene therapy research
  • Lipoproteins and Cardiovascular Health
  • Cytomegalovirus and herpesvirus research
  • Herpesvirus Infections and Treatments
  • Viral Infections and Immunology Research
  • High-Temperature Coating Behaviors
  • Ferroptosis and cancer prognosis
  • Hepatitis C virus research
  • COVID-19 Clinical Research Studies
  • Lung Cancer Treatments and Mutations
  • Hydrogels: synthesis, properties, applications
  • Endoplasmic Reticulum Stress and Disease
  • Nuclear and radioactivity studies
  • Exercise and Physiological Responses
  • Nanoparticle-Based Drug Delivery

Huazhong University of Science and Technology
2022-2025

Fujian Medical University
2019-2024

Sun Yat-sen University
2022-2024

Jinling Institute of Technology
2023

Nanjing Tech University
2023

Ministry of Education of the People's Republic of China
2022

China Agricultural University
2012-2014

Gastric cancer (GC) is one of the most common human cancers with high rate recurrence, metastasis and mortality. Aberrantly expressed microRNAs (miRNAs) are associated invasion in various cancers. Recently, miR-188-5p has been indicated as an oncogene GC since it promotes cell growth metastasis. However, underlying molecular mechanism remains to be fully defined. Using Significance Analysis Microarrays (SAM) screening, we identified that overall survival lymph node patients GC. The...

10.1186/s12885-019-5731-0 article EN cc-by BMC Cancer 2019-05-28

Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High-fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis. How HCC cells regulate ROS level escape the high fat diet (HFD) stress remains unclear. Herein, this work reports critical anti-ROS/apoptotic role ubiquitin-like protein interferon stimulated gene 15 (ISG15) HFD-promoted HCC. In mouse models clinical samples, upregulation...

10.1002/advs.202416401 article EN cc-by Advanced Science 2025-03-24

Abstract The present study investigated the dissolution and oxidation corrosion behaviors of Hastelloy exposed to static liquid lead‐bismuth eutectic (LBE) at 500°C with an oxygen concentration 1 × 10 −6 mass%. exhibited better LBE resistance than Monel alloy. Both were observed in Hastelloy, maximum penetration depth spinel layer thickness corroded sample after 4000 h exposure reached 120 ± 36 21 12 µm, respectively. Annealing twin boundaries provided favorable paths accelerated into...

10.1002/maco.202314135 article EN Materials and Corrosion 2024-02-02

The complete genomic sequence of a Pekin duck origin reovirus (DRV) from China was determined. genome comprises 23,419 bp, with segments ranging 1,191 bp (S4) to 3,959 (L1). Pairwise comparisons and phylogenetic analysis indicate that the is more closely related new type Muscovy (N-MDRV) identified recently than chicken avian orthoreovirus (ARV) originally described (ARV-Md).

10.1128/jvi.02512-12 article EN Journal of Virology 2012-11-01

The incidence and mortality of lung cancer rank top three all cancers worldwide. Accounting for 85% the total number cancer, non-small cell (NSCLC) is an important factor endangering human health. Recently, targeted therapies against driver mutations epigenetic alterations have made encouraging advances that benefit NSCLC patients. Druggable mutations, which mainly occur in EGFR, KRAS, MET, HER2, ALK, ROS1, RET BRAF, been identified more than a quarter A series highly selective mutant...

10.32604/oncologie.2022.027545 article EN cc-by ONCOLOGIE 2022-01-01

Adipose-tissue is a central metabolic organ for whole-body energy homeostasis. Here, we find that highly expressed H1.2, linker histone variant, senses thermogenic stimuli in beige and brown adipocytes. Adipocyte H1.2 regulates genes inguinal white-adipose-tissue (iWAT) affects expenditure. deletion (H1.2AKO) male mice show promoted iWAT browning improved cold tolerance; while overexpressing shows opposite effects. Mechanistically, binds to the promoter of Il10rα, which encodes an Il10...

10.1038/s41467-023-39713-w article EN cc-by Nature Communications 2023-07-06

Nonsmall cell lung cancer (NSCLC) is highly malignant with limited treatment options, platinum-based chemotherapy a standard for NSCLC resistance commonly seen. cells exploit enhanced antioxidant defense system to counteract excessive reactive oxygen species (ROS), which contributes largely tumor progression and chemotherapy, yet the mechanisms are not fully understood. Recent studies have suggested involvement of histones in cellular response; however, whether major histone variant H1.2...

10.1073/pnas.2306288120 article EN cc-by-nc-nd Proceedings of the National Academy of Sciences 2023-09-20

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide, and viral X protein (HBx) an etiological factor in HCC development. HBx a high-turnover protein, but knowledge of role deubiquitinating enzymes (DUBs) maintaining homeostasis very limited. We used 74-DUB library-based yeast two-hybrid assay determined that novel DUB, valosin-containing protein-interacting 1 (VCPIP1), interacted with HBx. VCPIP1 its C-terminal amino acids 863 to 1221...

10.1128/jvi.00611-22 article EN cc-by Journal of Virology 2022-06-13

The complete proviral sequence of a Muscovy duck-origin reticuloendotheliosis virus (REV) associated with spontaneously occurring neoplastic disease in 2011 Zhejiang province, China, was determined. Comparative analyses indicate that the present REV is most closely related to chicken-origin isolate HLJR0901 and goose-origin Goose/3410/06. These findings suggest chickens or geese may transmit ducks.

10.1128/jvi.02531-12 article EN Journal of Virology 2012-11-01

Clarification of the relationship between oxygen diffusion and microstructural evolution in liquid lead-bismuth eutectic (LBE) is great importance for understanding consequently tailoring oxidation process. In present study, a Si-modified ferritic martensitic steel was exposed to oxygen-saturated LBE at 500°C various times interface internal zone matrix investigated. Microstructural characterisation reveals that grain boundaries lath provide fast pathway diffusion, resulting high amount...

10.1080/1478422x.2022.2115436 article EN Corrosion Engineering Science and Technology The International Journal of Corrosion Processes and Corrosion Control 2022-08-30

Kaposi’s sarcoma-associated herpesvirus (KSHV) preferentially infects and causes sarcoma (KS) in male patients. However, the biological mechanisms are largely unknown. This study was novel confirming extensive nuclear distribution of androgen receptor (AR) its co-localization with viral oncoprotein latency-associated antigen KS lesions, indicating a transcription way AR pathogenesis. The endogenous also remarkably higher KSHV-positive B cells than KSHV-negative responded to ligand treatment...

10.1371/journal.ppat.1009947 article EN cc-by PLoS Pathogens 2021-09-20

Hepatitis B virus (HBV) spliced variants are associated with viral persistence or pathogenicity. doubly protein (HBDSP), which has been previously reported as a pleiotropic transactivator protein, can potentially serve an HBV virulence factor. However, the underlying mechanisms of HBDSP in HBV-associated liver diseases remain to be elucidated. In this study, we revealed that promotes cellular apoptosis and induces wt-p53-dependent apoptotic signaling pathway wt-p53 hepatocellular cells by...

10.1128/jvi.01087-23 article EN cc-by Journal of Virology 2023-11-06

Abstract Developing facile, green, and efficient synthetic methodology for preparing surface‐functionalized nanogels has attracted tremendous attention in the field of polymer chemistry biomaterials engineering. Herein, a series “clickable” P(MAA‐PMA) with reactive alkyne groups were conveniently prepared by “one‐pot” reflux‐precipitation polymerization (RPP), their particle sizes zeta potentials are solid content‐dependent. Using P(MAA‐PMA)‐1 as model, physicochemical properties including...

10.1002/app.54908 article EN Journal of Applied Polymer Science 2023-11-16

Abstract Background Immunogenic cell death (ICD) is a type of regulated that plays crucial role in activating the immune system response to various stressors, including cancer cells and pathogens. However, involvement ICD human against malaria remains be defined. Methods In this study, data from Plasmodium falciparum infection cohorts, derived cross-sectional studies, were analysed identify subtypes their correlation with parasitaemia responses. Using consensus clustering, identified,...

10.1186/s12936-024-04877-3 article EN cc-by Malaria Journal 2024-02-15
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