A5080802786- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Nerve injury and regeneration
- Tryptophan and brain disorders
- Nanoparticle-Based Drug Delivery
- Gastrointestinal motility and disorders
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- Ginger and Zingiberaceae research
- Spinal Cord Injury Research
- Nanoplatforms for cancer theranostics
- Advanced Glycation End Products research
- Advanced biosensing and bioanalysis techniques
- Neuropeptides and Animal Physiology
- Autophagy in Disease and Therapy
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Restless Legs Syndrome Research
- Immune cells in cancer
- S100 Proteins and Annexins
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
Jiangnan University
2018-2025
Institute of Process Engineering
2016-2018
Southwest Jiaotong University
2014-2018
Chengdu University
2014-2017
A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on magnetic nanocluster. In addition to the good stability and controllability, IMS also exhibits satisfactory binding avidity circulating tumor cells but stealth property leukocytes. As result, rare can be effectively enriched undetectable background.
Abstract The chemotherapy of glioblastoma is severely hindered by the immunosuppressive tumor microenvironment, especially growth factor β (TGF‐β), an cytokine. In this study, it proposed to employ RNAi‐based immunomodulation modify immune microenvironment and improve effect chemotherapy. Herein, a nanotheranostic system (Angiopep LipoPCB(Temozolomide+BAP/siTGF‐β), ALBTA) with dual targeting ROS response established for intracranial treatment. traceable nanoparticles exhibit strong siRNA...
Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson’s disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to unknown. To answer this question, mice received MPTP intraperitoneally construct subacute model and were then supplemented with orally 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, neurogenesis...
Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels the peripheral circulatory system of Parkinson's disease (PD) patients. TMAO is a gut microbiota metabolite that can cross blood-brain barrier and strongly related to neuroinflammation. Neuroinflammation one pathological drivers PD. Herein, we investigated effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model mice. pretreatment was given by adding 1.5% (w/v) drinking water mice...
Accumulative studies suggest that inflammatory bowel disease (IBD) may cause multiple central nervous system (CNS) pathologies. Studies have found indoleamine-2,3-dioxygenase (IDO, rate-limiting enzyme of the kynurenine (Kyn) pathway) deficient mice were protected from endotoxin induced cognitive impairment, and Kyn administration memory deficits in both control IDO-deficient mice. However, there is no investigation brain pathway IBD, thus we investigated whether dextran sulfate sodium...
JOURNAL/nrgr/04.03/01300535-202508000-00026/figure1/v/2024-09-30T120553Z/r/image-tiff Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon 7-mediated signaling contributes to Parkinson’s disease remains unknown. Here we report that is markedly up-regulated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–induced mouse model of and co-localizes with microglial cells. Both selective cyclic guanosine monophosphate adenosine synthase...
Neuronal senescence is a common pathological feature of various neurodegenerative diseases, with ferroptosis playing significant role. This study aims to investigate the role ErbB4 receptor activation in preventing D-Galactose (D-gal)-induced neuronal senescence. Mice subjected D-gal-induced aging were administered small molecule agonist (E4A), identified via virtual screening, melatonin, or combination both. Behavioral assessments conducted evaluate therapeutic efficacy memory and cognitive...
Currently unsatisfactory treatment of myocardial infarction (MI) is due to the unbridled inflammation and delayed diagnosis at early stage. To address these problems, firstly, phosphatidylserine (PS) was used modulate phenotypes macrophages (MΦ) resolve via binding PS receptors (PSR) on macrophage surface. Secondly, highly-sensitive magnetic iron oxide nanocubes (MIONs) were adopted realize visualization resonance imaging (MRI). However, major drawback for MIONs as contrast agents their...
Hypoxia-responsive prodrug micelles to deliver anticancer drug, which can selectively release the drugs treat hypoxic tumor cells.
The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in literature. Numerous studies have demonstrated that activation epidermal growth factor receptor 4 (ErbB4) is crucial neuronal injury and regeneration processes. This study investigated role targeted ErbB4 through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), mitigating PS-MPs-induced injury. findings revealed significantly ameliorated cognitive behavioral deficits...
Parkinson's disease (PD) is characterized by early-onset olfactory dysfunction preceding motor symptoms, yet its mechanisms remain elusive. Based on the studies microbiota-gut-brain axis, microbiota-nose-brain axis might be involved in pathogenesis of PD. However relative are rare. By consecutive 14-days intranasally transplanting bacteria, we established mice models exhibiting nasal microbiota dysbiosis (NMD), including animal group received intranasal drops fecal bacterial suspension from...
Co-delivery of siRNAs and chemotherapeutic drugs to kill tumors have achieved superior tumor growth inhibition. However, due with different molecular properties, co-delivery carriers use more cationic materials bind excessive inert embed drugs, causing low drug-loading contents systemic toxicity. To achieve this goal, doxorubicin (DOX) is chemically conjugated stearoyl chloride (C18) through N-methyldiethanol amine (N) as cross-linker form amphiphilic C18-N-DOX. C18-N-DOX contains a tertiary...