A5037746426- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Spinal Cord Injury Research
- Glycosylation and Glycoproteins Research
- Axon Guidance and Neuronal Signaling
- Ginger and Zingiberaceae research
- Carbohydrate Chemistry and Synthesis
- Alzheimer's disease research and treatments
- Hemispheric Asymmetry in Neuroscience
- Virus-based gene therapy research
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Zebrafish Biomedical Research Applications
- Bone Metabolism and Diseases
- Advanced Glycation End Products research
- Gastrointestinal motility and disorders
- Stress Responses and Cortisol
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Signaling Pathways in Disease
- Neurological Disease Mechanisms and Treatments
Jiangnan University
2014-2025
Shantou University
2000-2019
Shantou University Medical College
2000-2019
GTx (United States)
2011-2018
Jiaozuo University
2016
Zhejiang University
2009
Centre National de la Recherche Scientifique
2005
Neurocentre Magendie
2005
Kiel University
2002-2004
Jichi Medical University
2000
Increasing evidence suggests that the gut microbiota may represent potential strategies for Parkinson’s disease (PD) treatment. Our previous research revealed a decreased abundance of Akkermansia muciniphila (Akk) in PD mice; however, whether Akk is beneficial to unknown. To answer this question, mice received MPTP intraperitoneally construct subacute model and were then supplemented with orally 21 consecutive days. Motor function, dopaminergic neurons, neuroinflammation, neurogenesis...
Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels the peripheral circulatory system of Parkinson's disease (PD) patients. TMAO is a gut microbiota metabolite that can cross blood-brain barrier and strongly related to neuroinflammation. Neuroinflammation one pathological drivers PD. Herein, we investigated effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model mice. pretreatment was given by adding 1.5% (w/v) drinking water mice...
Accumulative studies suggest that inflammatory bowel disease (IBD) may cause multiple central nervous system (CNS) pathologies. Studies have found indoleamine-2,3-dioxygenase (IDO, rate-limiting enzyme of the kynurenine (Kyn) pathway) deficient mice were protected from endotoxin induced cognitive impairment, and Kyn administration memory deficits in both control IDO-deficient mice. However, there is no investigation brain pathway IBD, thus we investigated whether dextran sulfate sodium...
JOURNAL/nrgr/04.03/01300535-202508000-00026/figure1/v/2024-09-30T120553Z/r/image-tiff Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon 7-mediated signaling contributes to Parkinson’s disease remains unknown. Here we report that is markedly up-regulated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine–induced mouse model of and co-localizes with microglial cells. Both selective cyclic guanosine monophosphate adenosine synthase...
Neuronal senescence is a common pathological feature of various neurodegenerative diseases, with ferroptosis playing significant role. This study aims to investigate the role ErbB4 receptor activation in preventing D-Galactose (D-gal)-induced neuronal senescence. Mice subjected D-gal-induced aging were administered small molecule agonist (E4A), identified via virtual screening, melatonin, or combination both. Behavioral assessments conducted evaluate therapeutic efficacy memory and cognitive...
Parkinson's disease (PD) is a progressive neurodegenerative disease, involving resting tremor and bradykinesia, for which no recognized therapies or drugs are available to halt slow progression. In recent years, natural botanic products have been considered relatively safe, with limited side effects, expected become an important source clinical mediation of PD in the future. Our study focuses on ability loganin, compound derived from fruits cornus, mediate neuroprotection mouse model PD....
The cell neural adhesion molecule contactin-2 plays a key role in axon extension and guidance, fasciculation, myelination during development. We thus asked, whether is also important nervous system regeneration after trauma. In this study, we used an adult zebrafish spinal cord transection model to test the functions of regeneration. expression patterns at different time points injury were studied mRNA level by qPCR situ hybridization, protein levels immunohistological localization detected...
A decrease in the level of O‐acetylated sialic acids observed colorectal carcinoma may lead to an increase expression sialyl Lewis X , a tumor‐associated antigen, which is related progression cancer metastasis. The underlying mechanism for this reduction is, however, not fully understood. Two enzymes are thought be primarily responsible turnover O‐acetyl ester groups on acids; sialate‐ O ‐acetyltransferase (OAT) and ‐acetylesterase (OAE). We have previously reported characterization OAT...
The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in literature. Numerous studies have demonstrated that activation epidermal growth factor receptor 4 (ErbB4) is crucial neuronal injury and regeneration processes. This study investigated role targeted ErbB4 through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), mitigating PS-MPs-induced injury. findings revealed significantly ameliorated cognitive behavioral deficits...