A5100776261- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Silk-based biomaterials and applications
- Immunotherapy and Immune Responses
- Acoustic Wave Resonator Technologies
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Ferroelectric and Piezoelectric Materials
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Polyamine Metabolism and Applications
- Macrophage Migration Inhibitory Factor
- Genomics, phytochemicals, and oxidative stress
- Renal and related cancers
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Plant and animal studies
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
Jiangnan University
2025
Yunnan University
2025
Xi'an Jiaotong University
2019-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Zhejiang Ocean University
2022-2023
Lanzhou University
2023
Minzu University of China
2023
Second Xiangya Hospital of Central South University
2017-2022
Central South University
2012-2022
Henan University of Technology
2021
A long-term high-fat diet (HFD) is one of the high-risk factors for intestinal barrier damage. Docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) has multiple biological activities, while its protective effect on HFD-caused jejunum injury remains unknown. Thus, present study investigated DHA-PS HFD-induced in mice. Our results showed that (100 mg per kg d) could protect against by decreasing levels inflammatory such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α)...
Neuronal senescence is a common pathological feature of various neurodegenerative diseases, with ferroptosis playing significant role. This study aims to investigate the role ErbB4 receptor activation in preventing D-Galactose (D-gal)-induced neuronal senescence. Mice subjected D-gal-induced aging were administered small molecule agonist (E4A), identified via virtual screening, melatonin, or combination both. Behavioral assessments conducted evaluate therapeutic efficacy memory and cognitive...
Ovarian cancer (OC) is a common female disease with poor prognosis. But the possible mechanism of OC tumor progression remains an active area research. This study intended to explore effect metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on proliferation and apoptosis its mechanism.MALAT1 miR-503-5p expressions in human cell lines normal ovarian epithelial (HOSE) line were measured using qRT-PCR. SKOV3 divided into 4 groups: pcDNA3.1 group, pcDNA3.1-MALAT1 si-NC si-MALAT1...
Methyl-CpG-binding protein 2 (MeCP2) facilitates the carcinogenesis and progression of several types cancer. However, its role in breast cancer relevant molecular mechanism remain largely unclear. In this study, analysis Cancer Genome Atlas (TCGA) data that MeCP2 expression was significantly upregulated tissues, high correlated with poor overall survival. Knockdown inhibited cell proliferation G1-S cycle transition migration as well induced apoptosis vitro. Moreover, knockdown suppressed...
Aim: The effects of MALAT1 from human adipose-derived stem cell (ADSC) exosomes in skin wound healing were investigated. Material & methods: viability, apoptosis and migration ability fibroblasts (HSFs) evaluated by Cell Counting Kit-8 assay, flow cytometry scratch respectively. A mouse model was established to evaluate the role exosomal vivo. Results: Human ADSC promoted proliferation HSFs increased expression. silencing ADSCs inhibited HSF viability migration, angiogenesis upregulating...
The present work investigated the enzymolysis kinetics, thermodynamics and model of porcine cerebral protein (PCP) which was pretreated by single-frequency countercurrent pulsed ultrasound. kinetic constants for ultrasonic traditional have been determined. Results showed that value KM in PCP (UPCP) decreased 9% over enzymolysis. values reaction rate constant (k) UPCP increased 207%, 121%, 62%, 45% at 293, 303, 313 323 K, respectively. For thermodynamic parameters, ultrasound activation...
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a tetramethylfolate enzyme involved in folate metabolism. The aim of this study to determine the effect MTHFD2 on proliferation and metastasis colorectal cancer (CRC).MTHFD2 was silenced or overexpressed CRC cells. qRT-PCR Western blotting were used analyze mRNA protein expression, respectively. MTT assay colony forming detect cell formation ability. cycle apoptosis changes detected by flow cytometry. Transwell experiments migration...
// Ke Cao 1, * , Jingjing Li 2, Jia Chen Qian 3 Aijun Wang 4 Xiang 5 Wei Xiong 6 Jintian Tang 7 Shijie 8 Yong 9 Yao 2 Yan Cheng 10 and Jianda Zhou 1 Department of Oncology Third Xiangya Hospital, Central South University, Changsha, China Plastic Surgery Burn Second Surgical Bioengineering Laboratory, Surgery, UC Davis School Medicine, Sacramento, California, USA Dermatology Cancer Research Institute, Key Laboratory Carcinogenesis Ministry Health, Institute Medical Physics Engineering,...
Metabolic pathways such as glycolysis or oxidative phosphorylation play a key role in regulating macrophage function during inflammation and tissue repair. However, how exactly the VHL–HIF–glycolysis axis is involved of tissue-resident macrophages remains unclear. Here we demonstrate that loss VHL myeloid cells resulted attenuated pulmonary type 2 fibrotic responses, accompanied by reduced eosinophil infiltration, decreased IL-5 IL-13 concentrations, ameliorated fiber deposition upon...
FK506-binding proteins (FKBPs) belong to the peptidyl-prolyl cis/trans isomerase (PPIase) Super-family and are involved in a wide range of biological processes including protein folding, hormone signalling, plant growth stress responses. However, FKBPs their functions have not been identified tea. In this study, we searched 21 FKBP genes tea genome using consensus model FK506 binding domain (PF00254). Their phylogeny, classification, structure, motifs, interactors expression patterns were...
The impact of polystyrene microplastics (PS-MPs) on the nervous system has been documented in literature. Numerous studies have demonstrated that activation epidermal growth factor receptor 4 (ErbB4) is crucial neuronal injury and regeneration processes. This study investigated role targeted ErbB4 through a small molecule agonist, 4-bromo-1-hydroxy-2-naphthoic acid (C11H7BrO3, E4A), mitigating PS-MPs-induced injury. findings revealed significantly ameliorated cognitive behavioral deficits...
Purpose: Alkaloids are naturally occurring chemical compounds that widely distributed in plants, and have pharmaceutical values low toxicity. In recent years, some of them been demonstrated to be promising therapeutic drug candidates for cancer treatment. Herein, we tried explore the antitumor effect dehydrocorydaline (DHC), a natural alkaloid isolated from Corydalis , on malignant melanoma. Methods: We treated two metastatic melanoma cell lines, A375 MV3, normal melanocyte line, PIG1, with...
Hepatocellular carcinoma (HCC) is one of the most common types cancer that associated with poor quality life in patients and a global health burden. The mechanisms involved development progression HCC remain poorly understood.Hepatocellular human samples cell lines were subjected to qRT-PCR for expression assessment. CCK-8 assay, Transwell migration invasion applied function detection. Animal experiment was used measure SNHG17 on growth vivo. Western blot conducted evaluate level EMT cells....
The possible underlying mechanisms of EPA-PS and DHA-PS for the generation clearance Aβ alleviation Aβ-induced neurotoxicity in cellular models.