A5100667144- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Balance, Gait, and Falls Prevention
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Nanopore and Nanochannel Transport Studies
- SARS-CoV-2 detection and testing
- Vestibular and auditory disorders
- Anaerobic Digestion and Biogas Production
- Supercapacitor Materials and Fabrication
- Advanced Sensor and Energy Harvesting Materials
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- RNA modifications and cancer
- 2D Materials and Applications
- MXene and MAX Phase Materials
- Cancer-related molecular mechanisms research
- Non-Invasive Vital Sign Monitoring
- Gait Recognition and Analysis
- Electrohydrodynamics and Fluid Dynamics
- Membrane Separation Technologies
- NF-κB Signaling Pathways
- Advanced Biosensing Techniques and Applications
- High voltage insulation and dielectric phenomena
- Electrowetting and Microfluidic Technologies
Huashan Hospital
2024-2025
Fudan University
2024-2025
Xiamen University
2023-2025
Shijiazhuang Tiedao University
2024
Lanzhou University of Technology
2023-2024
University of New England
2021-2024
Henan Agricultural University
2021-2024
Anhui Medical University
2024
Guangxi Normal University
2024
Imperial College London
2022-2024
Antibacterial agents with high antibacterial efficiency and bacteria-binding capability are highly desirable. Herein, we describe the successful preparation of Cu2WS4 nanocrystals (CWS NCs) excellent activity. CWS NCs small size (∼20 nm) achieve more than 5 log (>99.999%) inactivation both Staphylococcus aureus (Gram-positive) Escherichia coli (Gram-negative) at low concentration (<2 μg mL-1) or without ambient light, which is much better most reported nanomaterials (including Ag, TiO2,...
A simple microfluidic-integrated lateral flow recombinase polymerase amplification (MI-IF-RPA) assay was developed for rapid COVID-19 detection.
Ultrasmall MoSe<sub>2</sub> nanodots were directly prepared in aqueous solution and their use for photothermal therapy was demonstrated.
Developing novel antibacterial agents to combat bacterial infection has been an everlasting task for scientists, due the drug resistance evolved by bacteria during antibiotic treatment. In this work, we used polydopamine (PDA) modify MoS2 nanosheets (MoS2 NSs) and then grew silver nanoparticles (AgNPs) on their surface form MoS2@PDA-Ag (MPA as multimodal nanoagents treat Staphylococcus aureus (S. aureus) biofilms S. infected wounds. vitro results show that treatment with MPA NSs under...
Multifunctional RGD-QD-MoS<sub>2</sub> nanosheets were prepared and used for targeted fluorescent imaging photothermal therapy (PTT) of cancer.
Tumor-derived extracellular vesicles (tEVs) are essential mediators of tumor progression and therapeutic resistance, yet their secretion dynamics cargo composition in response to therapies remain poorly understood. Here, we present STAMP, specific click-tagging driven by aptamer for tEV labeled with a metabolic timestamp, which exploits the unique kinetics thermodynamics significantly enhance local concentration clickable probes on tEVs covalent attachment resulting selective microfluidic...
Here, a fully integrated multicolor immunosensor was developed for sensitive and reliable semiquantitative analysis of HIV-1 p24, which integrates the multistep reactions horseradish peroxidase (HRP)-linked immunoassay gold nanorod (AuNR)-based assay into single microfluidic chip. The HRP-linked functions by moving magnetic beads bound to capture antibody through different aqueous phases containing reagents. HRP-catalyzed oxidation 3,3′,5,5′-tetramethylbenzidine (TMB) is used mediate AuNRs...
Abstract Consumer wearables and sensors are a rich source of data about patients’ daily disease symptom burden, particularly in the case movement disorders like Parkinson’s (PD). However, interpreting these complex into so-called digital biomarkers requires complicated analytical approaches, validating sufficient unbiased evaluation methods. Here we describe use crowdsourcing to specifically evaluate benchmark features derived from accelerometer gyroscope two different datasets predict...
Dynamic brain monitoring can mitigate traumatic injury (TBI) deterioration and enable precise treatment. Despite many studies on systems for neuroscience applications, current technologies are limited in providing a continuous real-time readout of multiple biomarkers simultaneously because sensor performance signal interference. Regression modeling, being subfield machine-learning (ML) algorithm, offers great advantages enhancement prediction. However, ML-integrated optical fiber sensors...
Extracellular vesicle PD-L1 (programmed death-1 ligand 1) is of greater value in tumor diagnosis, prognosis, and efficacy monitoring anti-PD-1/PD-L1 immunotherapy. However, soluble interferes with the accurate detection extracellular (EV) PD-L1. Here, we developed a microfluidic differentiation method for PD-L1, without interference soluble, by DNA computation lipid probes aptamer as inputs (DECLA). For DECLA method, cholesterol-DNA probe was designed that efficiently embeds into EV...
A previous study found that 1-phenylethanol (1PE) was a major endogenous volatile compound in tea (Camellia sinensis) flowers and can be transformed to glycosically conjugated 1PE (1PE-Gly). However, occurrences of 1PE-Gly plants remain unknown. In this study, four 1PE-Glys have been isolated from flowers. Three them were determined as (R)-1PE β-d-glucopyranoside ((R)-1PE-Glu), (S)-1PE-Glu, (S)-1PE β-primeveroside ((S)-1PE-Pri), respectively, on the basis NMR, MS, LC-MS, GC-MS evidence. The...
In vivo monitoring of cargo protein delivery is critical for understanding the pharmacological efficacies and mechanisms during cancer therapy, but it still remains a formidable challenge because difficulty in observing nonfluorescent proteins at high resolution sensitivity. Here we report an outer-frame-degradable nanovehicle featuring near-infrared (NIR) dual luminescence real-time tracking vivo. Upconversion nanoparticles (UCNPs) fluorophore-doped degradable macroporous silica (DS) with...
Freezing of gait (FoG) prediction, combined with rhythmic laser cues, may help Parkinson's disease (PD) patients overcome FoG episodes. This study aimed to utilize the impaired patterns preceding build a machine-learning-based model for prediction. Acceleration signals were collected using an accelerometer attached lower back 12 PD while they performing designed FoG-provoking walking tasks. Step-based features and conventional detection extracted from signals, based on which two prediction...
Stop codon readthrough (SCR) has important biological implications but remains largely uncharacterized. Here, we identify 1,009 SCR events in plants using a proteogenomic strategy. Plant candidates tend to have shorter transcript lengths and fewer exons splice variants than non-SCR transcripts. Mass spectrometry evidence shows that stop codons involved can be recoded as 20 standard amino acids, some of which are also supported by suppressor tRNA analysis. We observe multiple functional...
Abstract Accumulation of vimentin is the core event in epithelial–mesenchymal transition (EMT). Post‐translational modifications have been widely reported to play crucial roles imparting different properties and functions vimentin. Here, a novel modification vimentin, acetylated at Lys 104 (vimentin‐K104Ac) identified, which stable lung adenocarcinoma (LUAD) cells. Mechanistically, NACHT, LRR, PYD domain‐containing protein 11 (NLRP11), regulator inflammatory response, bind promote...