A5068468688- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- 3D Printing in Biomedical Research
- Phagocytosis and Immune Regulation
- Silk-based biomaterials and applications
- Extracellular vesicles in disease
- Hepatitis B Virus Studies
- Biochemical and Structural Characterization
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Endoplasmic Reticulum Stress and Disease
- Cancer Mechanisms and Therapy
- Beetle Biology and Toxicology Studies
- Advanced Materials and Mechanics
- Supramolecular Self-Assembly in Materials
- Silymarin and Mushroom Poisoning
- HIV-related health complications and treatments
Sun Yat-sen University
1988-2024
Zhuhai People's Hospital
2023-2024
Jinan University
2023-2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Second Affiliated Hospital of Guangzhou Medical University
2019-2023
Guangzhou Medical University
2019-2023
Guangdong Medical College
2023
Chinese University of Hong Kong
2020-2021
Wuhan University
2013-2016
A novel dual-pH sensitive charge-reversal strategy is designed to deliver antitumor drugs targeting tumor cells and further promote the nuclei internalization by a stepwise response mildly acidic extracellular pH (≈6.5) of endo/lysosome (≈5.0). Poly(l-lysine)-block–poly(l-leucine) diblock copolymer synthesized lysine amino residues are amidated 2,3-dimethylmaleic anhydride form β-carboxylic amide, making polypeptides self-assemble into negatively charged micelles. The amide can be hydrolyzed...
Tumor-associated macrophages (TAMs) usually display the tumor-promoting M2 phenotype rather than tumoricidal M1 phenotype. Thus, M2-to-M1 repolarization of TAMs has emerged as a promising strategy for tumor immunotherapy nowadays. However, immune side effects remain great challenge, because phenotypic conversion into proinflammatory may also be induced in normal tissue. Here, aiming at repolarizing without altering M1/M2 polarization balance healthy organs, we develop micellar nanodrug with...
Abstract Immunotherapy has revolutionized oncology remarkably and gained great improvements in cancer therapy. However, tumor immunotherapy still encounters serious challenges, especially certain tumors barely respond to immunotherapy. The lack of immunogenicity subsequent insufficient antitumor immune activation is a pivotal reason. Here, general introduction the strengthening strategies for enhanced are reviewed. Specifically, nanotechnology nowadays playing important roles increasing...
A potent drug delivery strategy promotes tumor infiltration of T cells and unleashes antitumor immunity.
Hypoxia leads to up-regulation of PD-L1 and decreases T lymphocyte infiltration, thus boosting immunotherapeutic resistance tumors. Moreover, tumor-infiltrating myeloid cells such as myeloid-derived suppressor (MDSCs) correlate with potent immune suppressive activity the checkpoint blocking (ICB) in tumor sites. Here, a multifunctional nanoregulator incorporating MnO
Abstract Glioma is a common primary brain malignancy with poor prognosis. Chemotherapy the first‐line treatment for tumors but low efficiency of drugs in crossing blood–brain barrier (BBB) and drug resistance related to tumor hypoxia thwart its efficacy. Herein, theranostic nanodrug (iRPPA@TMZ/MnO) developed by incorporating oleic acid‐modified manganese oxide (MnO) temozolomide (TMZ) into polyethylene glycol‐poly(2‐(diisopropylamino)ethyl methacrylate‐based polymeric micelle containing...
Abstract Immunotherapy brings great benefits for tumor therapy in clinical treatments but encounters the severe challenge of low response rate mainly because immunosuppressive microenvironment. Multifunctional nanoplatforms integrating effective drug delivery and medical imaging offer tremendous potential cancer treatment, which may play a critical role combinational immunotherapy to overcome microenvironment efficient therapy. Here, nanodrug (BMS‐SNAP‐MOF) is prepared using glutathione...
Abstract Anticancer immunotherapy is hampered by the poor tumor immunogenicity and immunosuppressive microenvironment (TME). Herein, a liposome nanodrug co‐encapsulating doxycycline hydrochloride (Doxy) chlorin e6 (Ce6) to simultaneously induce autophagy inhibition mitochondria dysfunction for potentiating photo‐immunotherapy developed. Under near infrared laser irradiation, Ce6 generates cytotoxic reactive oxygen species (ROS) elicits robust photodynamic therapy (PDT)‐induced immunogenic...
Effective antitumor immunotherapy depends on evoking a cascade of cancer-immune cycles with lymph nodes (LNs) as the initial sites for activating immunity, making drug administration through lymphatic system highly attractive. Here, we describe nanomedicine dual responsiveness to pH and enzyme programmed activation immune system. The proposed can release STING agonist diABZI-C2-NH2 in LNs' acidic environment activate dendritic cells (DCs) T cells. Then, remaining hitchhikes activated (PD-1+...
Tumor immunotherapy like immune checkpoint blockade (ICB) shows great success nowadays but is severely limited by low response rates and immune-related adverse events (IRAEs). While photodynamic therapy (PDT) could efficiently eradicate tumor cells further induce responses to promote activating of T lymphocytes. Herein a nanodrug hierarchically incorporating photosensitizer PD-L1 antibody was developed for synergistic immuno-photodynamic therapy. A pH/enzyme dual-sensitive polymeric micelle...
Hepatitis B virus (HBV) infection is a major cause of chronic active hepatitis, cirrhosis, and primary hepatocellular carcinoma, all which are severe threats to human health. However, current clinical therapies for HBV limited by potential side effects, toxicity, drug-resistance. In this study, cell-penetrating peptide-conjugated peptide nucleic acid (PNA), Tat-PNA-DR, was designed target the direct repeat (DR) sequences HBV. Tat-PNA-DR effectively inhibited replication in HepG2.2.15 cells....
Developing strategies for efficient expansion of cancer stem-like cells (CSCs) in vitro will help investigate the mechanism underlying tumorigenesis and recurrence. Herein, we report a dynamic culture substrate tethered with integrin ligand-bearing magnetic nanoparticles via flexible polymeric linker to enable manipulation nanoscale ligand tether mobility. The cultured on high mobility develop into large semispherical colonies CSCs features, which can be abrogated by magnetically restricting...
The link between inflammation and the evolution of cancer is well established. Visualizing tracking both tumor proliferation associated inflammatory response within a living organism are vital for dissecting nexus these two processes crafting precise treatment modalities. We report creation synthesis an advanced NIR chemiluminescence probe that stands out its exceptional selectivity, extraordinary sensitivity at nanomolar concentrations, swift detection capabilities, broad application...
An extracellular pH and intracellular reduction dual-sensitive polymeric nanomicelle was developed for tumor microenvironment triggered selective cellular uptake controlled cytoplasm drug release.