A5100378262- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Invertebrate Immune Response Mechanisms
- Immune cells in cancer
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Neurobiology and Insect Physiology Research
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- Nutritional Studies and Diet
- Lung Cancer Research Studies
- Insect symbiosis and bacterial influences
- Health, Environment, Cognitive Aging
Air Force Engineering University
2025
Southwest University
2023-2025
Binzhou Medical University
2024
Harbin Medical University
2015-2024
First Affiliated Hospital of Harbin Medical University
2016-2024
Binzhou University
2024
Tianjin Medical University General Hospital
2020-2024
Shandong Agricultural University
2023
Sun Yat-sen University
2018-2022
Stomatology Hospital
2018-2022
It has been revealed that abnormal voxel-mirrored homotopic connectivity (VMHC) is present in patients with schizophrenia, yet there are inconsistencies the relevant findings. Moreover, little known about their association brain gene expression profiles. In this study, transcription-neuroimaging analyses using data from Allen Human Brain Atlas and case-control VMHC differences both discovery (meta-analysis, including 9 studies a total of 386 357 controls) replication (separate group-level...
Chemotherapy regimens containing cisplatin remain the first-line treatments for patients with oral squamous cell cancer (OSCC); however, treatment effect is often transient because of chemoresistance and recurrence. Understanding mechanisms in OSCC might provide novel targetable vulnerabilities. In present study, we revealed that Forkhead box D1 (FOXD1) upregulated predicted poor prognosis. Moreover, ectopic expression FOXD1 promoted, while silencing inhibited, epithelial-mesenchymal...
Neural stem cells in the postnatal telencephalic ventricular-subventricular zone (V-SVZ) generate new interneurons, which migrate tangentially through rostral migratory stream (RMS) into olfactory bulb (OB). The Sp8 and Sp9 transcription factors are expressed neuroblasts, as well immature mature interneurons V-SVZ-RMS-OB system. Here we show that coordinately regulate OB interneuron development: although null mutants no major defect, conditional deletion of both resulted a much more severe...
Abstract Breast cancer, the most frequently occurring malignant tumor, has high mortality rate, especially triple-negative breast cancer (TNBC). LncRNA-differentiation antagonizing non-protein coding RNA (lncRNA DANCR) been found that its aberrant expression was associated with tumor progression and it promising to be a potential target for therapy. The goal of present study explore biological effects underlying mechanism DANCR in cancer. Our results showed up-regulated TNBC tissues cells...
Cancer cells use aerobic glycolysis to sustain their proliferation. Long non‑coding RNA brain cytoplasmic 1 (BCYRN1) has been reported act as an oncogene in non‑small‑cell lung cancer (NSCLC). The present study investigated the role of BCYRN1 NSCLC glycolysis. expression was detected and tissues using reverse transcription‑quantitative PCR. effect on examined by measuring cell glucose catabolism lactate synthesis. relationships between microRNA (miR)‑149, miR‑149 pyruvate kinase M1/2 (PKM2)...
Prostate cancer ( PC a) prevails as the most commonly diagnosed malignancy in men and third leading cause of cancer‐related deaths developed countries. One distinct characteristics prostate is overexpression small ubiquitin‐like modifier SUMO )‐specific protease 1 SENP 1), upregulation contributes to malignant progression cell proliferation a. Previous studies have shown that expression micro RNA ‐145 (mi ‐145) was extensively deregulated a lines primary clinical samples. Independent target...
Immunotherapy based on BCG vaccination is an effective treatment in bladder cancer, but a positive response restricted to subset of patients and for limited period time only. This suggests that T cells antitumour responses are can become compromised cancer. To investigate the underlying mechanisms, we first identified peripheral blood monocytes tumour macrophages using pan-monocyte/macrophage marker CD14, found PD-L1 expression monocytes/macrophages cancer was significantly higher than...
Abstract Background Circulating tumor DNA (ctDNA) has been proven to be a promising tumor-specific biomarker in solid tumors, but its clinical utility risk stratification and early prediction of relapse for diffuse large B cell lymphoma (DLBCL) not well explored. Methods Here, using lymphoma-specific sequencing panel, we assessed the prognostic predictive utilities ctDNA measurements before, during, after first-line therapy 73 Chinese DLBCL patients. Results The pretreatment level serving as...
N7-Methylguanosine (m7G) and long non-coding RNAs (lncRNAs) have been widely reported to play an important role in cancer. However, there is little known about the relationship between m7G-related lncRNAs clear cell renal carcinoma (ccRCC). To find new potential biomarkers construct lncRNA prognostic signature for ccRCC, we retrieved transcriptome data clinical from The Cancer Genome Atlas (TCGA), divided entire set into train test with ratio of 1:1 randomly. were identified by Pearson...
Abnormal expression of microRNAs plays important role in tumor metastasis. Migration and invasion cancer cells accord for the metastasis deterioration breast cancer. However, regulatory migration has not completely understood yet. Here we found that microRNA-34c (miR-34c) was significantly downregulated metastatic tissue In vitro study showed miR-34c negatively regulated GIT1 protein by binding to 3'UTR mRNA. Consistently, upregulated Moreover, overexpression suppressed protein, this effect...
Abstract Lepidoptera, one of the largest orders within class Insecta , accounts for approximately 70% known pests affecting crops and forests. Therefore, immune research in lepidopteran model Bombyx mori offers valuable insights refining pest control strategies. Although numerous studies have investigated role phospholipase A2 (PLA2) immunity, on its tissues remains lacking insects. We previously found that BmsPLA2‐4 is highly expressed midgut, a key tissue silkworms. In this study, we...
Numerous studies have reported that long noncoding RNAs (lncRNAs) play critical roles in the development and progression of bladder cancer (BC). LncRNA snoRNA host gene 6 (SNHG6) is ectopically expressed tumor tissues patients with BC cell lines. However, little known about molecular mechanism SNHG6-mediated urothelial carcinoma migration invasion.We detected SNHG6 levels human specimens lines by quantitative real-time polymerase chain reaction Western blot, investigated its role using vitro...
Background: The incidence and mortality rate of gastric cancer has markedly declined over the past few decades, due to progress advances in development diagnostic treatment regimens. However, there is still a large portion patients who are first diagnosed during advanced stage when chemotherapy needed. Unfortunately, resistance chemotherapeutic agents most frequent occurrence treatment, which indicates need for discovery novel therapeutic anticancer drugs. Methods: tumor-suppression effect...
To explore the potential involvement of long non-coding RNA (lncRNA) NORAD in regulating progression Non-small cell lung cancer (NSCLC), and its possible mechanism.Relative level NSCLC tissues lines was determined. Its patients with different tumor staging (T1-T2, T3-T4) either lymphatic metastasis or not examined as well. Kaplan-Meier curves were depicted for assessing prognostic value NSCLC. Regulatory effects on proliferative ability NCI-H1650 HCC827 cells evaluated. Dual-luciferase...
As one of the earliest discovered long non‑coding (lnc)RNAs, lncRNA H19 imprinted maternally expressed transcript (H19) participates in regulating ischemic stroke. The present study aimed to investigate combined roles H19, microRNA (miR)‑29b, silent mating‑type information regulation 2 homolog 1 (SIRT1) and peroxisome proliferator‑activated receptor‑g co‑activator‑1α (PGC‑1α) following expression levels middle cerebral artery occlusion (MCAO) mouse model HT22 cells subjected oxygen‑glucose...
Background: Hypoxic microenvironment inside the tumor forces cells to up-regulate glycolytic pathway maintain a sufficient energy supply for growth.Activation of HIF1α under hypoxia condition is able regulate expression glycolysis-related genes, and results in proliferation metastasis cancer cells.However, mechanism underlying activation glycolysis induction by remains unclear.The present study aimed test if SENP1 regulates prostate (CaP) improving stability protein. Methods:We employed qPCR...
Insect immune-associated phospholipase A2 (PLA2 ) is an important target of pathogen invasion. Melanization, effective defense response, has significant correlations with other immune responses to coordinate attack against invaders. However, the effect PLA2 on melanization not yet been reported in insects or arthropods. In this work, we cloned a gene (BmsPLA2 ), and its protein had characteristic features secreted (sPLA2 ). After injection bacteria, BmsPLA2 expression sPLA2 activity...