A5089989081- RNA modifications and cancer
- MicroRNA in disease regulation
- interferon and immune responses
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- T-cell and Retrovirus Studies
- NF-κB Signaling Pathways
- ATP Synthase and ATPases Research
- Wnt/β-catenin signaling in development and cancer
- Mitochondrial Function and Pathology
- Helicobacter pylori-related gastroenterology studies
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Hippo pathway signaling and YAP/TAZ
- Bone Metabolism and Diseases
- Tissue Engineering and Regenerative Medicine
Guangzhou Medical University
2021-2024
Sun Yat-sen University
2018-2023
Third Affiliated Hospital of Sun Yat-sen University
2018-2022
Hubei University of Technology
2021
Qingdao University
2020
Sun Yat-sen Memorial Hospital
2018
Efficient removal of uranium (U) from aqueous solutions is crucial for ecological safety. Functionalized magnetic nanoparticles provide a promising strategy radionuclide recovery and separation. However, designing synthesizing adsorbents with high sorption capacity selectivity, accompanied by excellent stability reusability, remain challenge. In this work, novel amidoxime-functionalized flower-like Fe3O4@TiO2 core–shell microspheres are designed synthesized to efficiently remove U(VI) actual...
Breast cancer (BC) has a marked tendency to spread the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported contribute initiation progression. However, function mechanism of circRNAs BC bone metastasis (BC-BM) remain largely unknown.Bone-metastatic were screened using deep sequencing validated situ hybridization tissues with or without metastasis. The role circIKBKB inducing pre-metastatic niche formation was determined...
Chemotherapy regimens containing cisplatin remain the first-line treatments for patients with oral squamous cell cancer (OSCC); however, treatment effect is often transient because of chemoresistance and recurrence. Understanding mechanisms in OSCC might provide novel targetable vulnerabilities. In present study, we revealed that Forkhead box D1 (FOXD1) upregulated predicted poor prognosis. Moreover, ectopic expression FOXD1 promoted, while silencing inhibited, epithelial-mesenchymal...
Resistance to platinum-based chemotherapy is a major cause of therapeutic failure during the treatment epithelial ovarian cancer (EOC) patients. Our study aims elucidate molecular mechanisms by which ZNF711 down regulation promotes CISPLATIN resistance in EOC.ZNF711 expression 150 EOC specimens was examined using immunohistochemistry. and survival patients were assessed with Kaplan-Meier analysis. The effects on CDDP studied IC50, Annexin V, colony formation vitro, an vivo intra-peritoneal...
Mitochondrial dynamics play vital roles in the tumorigenicity and malignancy of various types cancers by promoting tumor-initiating potential cancer cells, suggesting that targeting crucial factors drive mitochondrial may lead to promising anticancer therapies. In current study, we report overexpression fission factor (MFF), which is upregulated significantly liver cancer-initiating cells (LCIC), promotes enhances stemness capability non-LCICs. MFF-induced evoked mitophagy asymmetric stem...
Abstract Sustaining DNA damage response (DDR) signalling via retention of DDR factors at damaged sites is important for transmitting damage-sensing and repair signals. Herein, we found that provoked the association ribosomes with IRES region in lncRNA CTBP1-DT, which overcame negative effect upstream open reading frames (uORFs), elicited novel microprotein damage-upregulated protein (DDUP) translation a cap-independent mechanism. Activated ATR kinase-mediated phosphorylation DDUP induced...
Abstract Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis. Identifying organ‐specific molecular determinants EVs can develop potential anti‐metastatic therapeutic targets. In current study, large oncosomes (LOs), atypically cancer‐derived EVs, are found play crucial role facilitating bone‐tropic metastasis hepatocellular carcinoma...
Abstract Purpose: The development of resistance to platinum-based chemotherapy remains the unsurmountable obstacle in cancer treatment and consequently leads tumor relapse. This study aims investigate mechanism by which loss RBMS3 induced chemoresistance epithelial ovarian (EOC). Experimental Design: FISH IHC were used determine deletion frequency expression 15 clinical EOC tissues 150 clinicopathologically characterized specimens. effects CBP/β-catenin antagonist PRI-724 examined clone...
Abstract Laryngeal squamous cell carcinoma (LSCC) is a common head and neck cancer. Despite recently improved management of LSCC, chemotherapy resistance patients remains challenge. In this study, we identified that long noncoding RNA FOXD2-AS1 regulates LSCC therapeutic by augmenting stemness. chemotherapy-resistant showed increased expression compared with in chemotherapy-sensitive patients, which predicted poor prognosis. Gain- or loss-of-function experiments upregulated maintained cancer...
Blocking genotoxic stress-induced NF-κB activation would substantially enhance the anticancer efficiency of chemotherapy. Unlike well-established classical pathway, agents-induced "nuclear-to-cytoplasmic" pathway is initiated from nucleus and transferred to cytoplasm. However, mechanism linking nuclear DNA damage signaling cytoplasmic IKK remains unclear. Here, we report that TRIM37, a novel E3 ligase, plays vital role in via monoubiquitination NEMO at K309 nucleus, consequently resulting...
Abstract The mechanisms underlying how cells subjected to genotoxic stress reestablish reduction-oxidation (redox) homeostasis scavenge stress-induced reactive oxygen species (ROS), which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we report that, via a TCF-independent mechanism, induces enrichment β-catenin in chromatin, where it forms complex with ATM phosphorylated-JDP2 PRMT5. This elicits histone H3R2me1/H3R2me2s-induced...
Abstract The incidence of bone metastases in hepatocellular carcinoma (HCC) has increased prominently over the past decade owing to prolonged overall survival HCC patients. However, mechanisms underlying bone‐metastasis remain largely unknown. In current study, HCC‐secreted lectin galactoside‐binding soluble 3 (LGALS3) is found be significantly upregulated and correlates with shorter bone‐metastasis‐free Overexpression LGALS3 enhances metastatic capability cells induces skeletal‐related...
Abstract Serine/arginine-rich splicing factor 7 (SRSF7), a known factor, has been revealed to play oncogenic roles in multiple cancers. However, the mechanisms underlying its have not well addressed. Here, based on N 6-methyladenosine (m 6 A) co-methylation network analysis across diverse cell lines, we find that gene expression of SRSF7 is positively correlated with glioblastoma (GBM) cell-specific m6A methylation. We then indicate novel regulator, which specifically facilitates methylation...
Abstract Balancing mRNA nuclear export kinetics with its decay is critical for homeostasis control. How this equilibrium aberrantly disrupted in esophageal cancer to acquire stem cell properties remains unclear. Here we find that the RNA-binding protein interleukin enhancer binding factor 2 (ILF2) robustly upregulated by nicotine, a major chemical component of tobacco smoke, via activation JAK2/STAT3 signaling and significantly correlates poor prognosis heavy-smoking patients cancer. ILF2...
The traditional bearing fault diagnosis methods have complex operation processes and poor generalization ability, while the accuracy of existing intelligent needs to be further improved. Therefore, a novel approach named CNN‐BLSTM for is presented based on convolutional neural network (CNN) bidirectional long short‐term memory (BLSTM) in this paper. This method directly takes collected one‐dimensional raw vibration signal as input adaptively extracts feature information through CNN. Then,...
Bone metastasis is one of the most common distant breast cancer, which could cause serious skeletal disease and increased cancer-related death. Therefore, identification novel target(s) to develop therapeutics would improve patient outcomes. The role NKX2-8 in modulation bone remodeling was determined using osteoclastogenesis micro-CT assays. expression examined via immunohistochemistry analysis 344 cancer tissues. mechanism underlying NKX2-8-mediated PTHrP downregulation investigated...
This paper investigates the design problem of fuzzy dynamic output feedback H∞ controller for nonlinear networked systems via mismatched membership functions and adaptive event-triggered (AET) mechanism. Firstly, an AET mechanism is introduced to save communication resources, which causes original system's premise variables be asynchronous. Then, considering influence functions, a model control system established. In addition, utilizing Lyapunov-Krasovskii(L-K) functional, sufficient...
<title>Abstract</title> The mechanisms underlying how cells dynamically remodel membrane phospholipids to prevent phospholipid peroxidation-induced damage and evade ferroptosis, which maintains the physiological function of cellular processes cell survival, remain unclear. Herein, we reported that lysophosphatidylcholine acyltransferase 1 (LPCAT1) played a critical role in ferroptosis resistance by increasing saturation via Land’s cycle, consequently reducing levels polyunsaturated fatty...
Metabolic enzyme-genes (MEs) play critical roles in various types of cancers. However, MEs have not been systematically and thoroughly studied pancreatic cancer (PC). Global analysis PC will help us to understand progressing provide new insights into therapy. In this study, we analyzed RNA sequencing data from The Cancer Genome Atlas (TCGA) (n = 180 + 4) GSE15471 36 36) discovered that metabolic pathways are disordered PC. Co-expression network modules were constructed using weighted gene...
<div>Abstract<p>Balancing mRNA nuclear export kinetics with its decay is critical for homeostasis control. How this equilibrium aberrantly disrupted in esophageal cancer to acquire stem cell properties remains unclear. Here we find that the RNA-binding protein interleukin enhancer binding factor 2 (ILF2) robustly upregulated by nicotine, a major chemical component of tobacco smoke, via activation JAK2/STAT3 signaling and significantly correlates poor prognosis heavy-smoking...