A5090586981- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Quantum optics and atomic interactions
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Cold Atom Physics and Bose-Einstein Condensates
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Radiopharmaceutical Chemistry and Applications
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Plant Gene Expression Analysis
- Photosynthetic Processes and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Advanced Fiber Laser Technologies
Huazhong University of Science and Technology
1999-2025
Union Hospital
2021-2025
Wuhan Union Hospital
2022-2025
Southeast University
2021-2025
Hangzhou DAC Biotech (China)
2025
Wuhan No.1 Hospital
2013-2024
Shanghai Tenth People's Hospital
2024
Shanghai Agrobiological Gene Center
2024
Ministry of Agriculture and Rural Affairs
2024
Tongji University
2024
We demonstrate efficient nonlinear frequency conversion in atomic Pb vapor under conditions where the linear susceptibility and effective are of same order. This is accomplished by using electromagnetically induced transparency to prepare a near-maximal coherence on Raman transition. strongly driven transition used convert an intense laser beam from 425 293 nm with efficiency $\ensuremath{\sim}40%$.
Abstract N6-methyladenosine (m6A), catalyzed by Mettl3 methyltransferase, is a highly conserved epigenetic modification in eukaryotic messenger RNA (mRNA). Previous studies have implicated m6A multiple biological processes, but the vivo function of has been difficult to study, because mettl3 mutants are embryonic lethal both mammals and plants. In this we used transcription activator-like effector nucleases generated viable zygotic mutant, Zmettl3m/m, zebrafish. We find that oocytes...
Cysteine-rich secretory protein 2 (CRISP2) is an important sperm and plays roles in spermatogenesis, modulation of flagellar motility, acrosome reaction, gamete fusion. Clinical evidence shows a reduced CRISP2 expression spermatozoa from asthenozoospermic patients, but the molecular mechanism underlying its reduction remains unknown. Herein, we carried out study focusing on asthenozoospermia. Initially, through analyzing methylation promoter activity sperm, observed decreased rather than...
Insulin resistance, a harbinger of the metabolic syndrome, is state compromised hormonal response resulting from dysregulation wide range insulin-controlled cellular processes. However, how insulin affects energy metabolism via long-term transcriptional regulation and whether boosting mitochondrial function alleviates resistance remains to be elucidated. Herein we reveal that directly enhances activity nuclear receptor ERRα GSK3β/FBXW7 signaling axis. Liver-specific deletion GSK3β or FBXW7...
Abstract DNA damage can induce autophagy; however, the underlying mechanism remains largely unknown. Here we report that leads to autophagy through ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition. caused by ultraviolet light (UV) or alkylating agent methyl methanesulphonate (MMS) results in phosphorylation small GTPase RhoB Chk1. Phosphorylation enhances its interaction with TSC2, promotes sumoylation PIAS1, which is required for RhoB/TSC...
Abstract Background Grape buds exhibit non-uniform, or delayed, break in early spring subtropical regions because the accumulation of chilling is insufficient. Hydrogen cyanamide (H 2 CN , HC) can partially replace to effectively promote bud sprouting and used widely warm winter areas. However, exact underlying mechanism grape release from endodormancy induced by HC remains elusive. Results In this study, transcriptome under vitro conditions following water treatment (control) was analyzed...
Abstract More and more patients suffered from Coronavirus disease 2019 (COVID-19) have got recovery gradually due to suitable intervention. Increasing data mainly studies the clinical characteristics of recovered COVID-19 patients, their molecular changes especially proteome also play same important role in understanding biological as do. In our study, we reported whole lung-ground glass-CT value-average mild/severe 3 months after discharge without underlying diseases was significantly lower...
Abstract Purpose The choice of continuous renal replacement therapy (CRRT) anticoagulation program for patients at high risk bleeding has always been a complex problem in clinical practice. Clinical regimens include regional citrate (RCA) and nafamostat mesylate (NM). This study aimed to evaluate the efficacy safety these two anticoagulants CRRT guide their use better. Patients methods Between January 2021 December 2022, 307 were screened this study. Forty-six finally enrolled: 22 group 24...
Given the increasing prevalence of obesity and metabolic syndrome, identification intrinsic molecular programs responsible for ensuring fuel homeostasis preventing disease is needed. We investigated whether orphan nuclear receptor estrogen-related α (ERRα), a major regulator energy metabolism, plays role in lipid development nonalcoholic fatty liver (NAFLD) response to chronic high-fat diet (HFD) consumption long-term fasting. Systemic ablation ERRα mice demonstrated clear beneficial effects...
It has been reported that melatonin can relieve the symptoms of chronic obstructive pulmonary disease (COPD) by improving sleep quality, is to say, pineal secreted hormone a protective effect in pathogenesis COPD, but its underlying mechanism remains unclear. In this study, we recruited 73 people into control (n = 22), stable COPD 20), and acute exacerbation 31) groups detect serum levels. Then, through mouse model, employed systematic study based on metabolomic transcriptomic analyses...
Bile acid: sodium symporter family protein 2 (BASS2) is a sodium-dependent pyruvate transporter, which transports from cytosol into plastid in plants. In this study, we investigated the function of chloroplast envelope membrane-localized BnaBASS2 seed metabolism and oil accumulation Brassica napus (B. napus). Four BASS2 genes were identified genome B. napus. BnaA05.BASS2 was overexpressed while BnaC04.BASS2-1 mutated by CRISPR Metabolite analysis revealed that manipulation caused significant...
Nonalcoholic steatohepatitis (NASH) is epidemiologically associated with obesity and diabetes can lead to liver cirrhosis hepatocellular carcinoma if left untreated. The intricate signaling pathways that orchestrate hepatocyte energy metabolism cellular stress, intrahepatic cell crosstalk, as well interplay between peripheral tissues remain elusive are crucial for the development of anti-NASH therapies. Herein, we reveal E3 ligase FBXW7 a key factor regulating hepatic catabolism, stress...
We report the demonstration of a pulsed atomic lead (Pb) vapor-based vacuum ultraviolet frequency converter from 233 to 186??nm with unity photon-conversion efficiency. This conversion is attained without phase matching.
Abstract HER2 (human epidermal growth factor receptor 2) is a transmembrane tyrosine kinase critical for cell and differentiation. As pivotal therapeutic target, has been extensively investigated in ADC drug development, resulting numerous innovative designs along with approval recent years. Among these, dual-payload ADCs, particularly those utilizing small molecules distinct mechanisms of action, represent promising yet still evolving area research. DXC018 novel HER2-targeting bispecific...