A5007824761- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Retinoids in leukemia and cellular processes
- Nuclear Receptors and Signaling
- HER2/EGFR in Cancer Research
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Hormonal Regulation and Hypertension
- Bioinformatics and Genomic Networks
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
McGill University
2016-2025
McGill University Health Centre
2013-2024
University of Macau
2024
Quality Research
2024
Concordia University
2019
Kumamoto University
2016
Saint John's Health Center
2013
Cold Spring Harbor Laboratory
2012-2013
Molecular Oncology (United States)
1997-2013
The Kinghorn Cancer Centre
2013
Abstract Estrogen receptor β (ERβ) is a novel steroid that expressed in rat prostate and ovary. We have cloned the mouse homolog of ERβ mapped gene, designated Estrb, to central region chromosome 12. The cDNA encodes protein 485 amino acids shares, respectively, 97% 60% identity with DNA- ligand-binding domains (m) ERα. Mouse binds an inverted repeat spaced by three nucleotides gel mobility shift assay transactivates promoters containing synthetic or natural estrogen response elements...
Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence the developing embryo as an endogenous substance has led suggestion that RA might be a natural morphogenetic agent. Although our understanding of molecular mechanism action improved considerably identification nuclear receptors for (RARs) RA-responsive genes, exact relationship between proposed activity remains characterized. Here, we show response element (RARE) present RAR...
Circadian rhythms result from feedback loops involving clock genes and their protein products. In mammals, 2 orphan nuclear receptors, REV-ERBα RORα, play important roles in the transcription of gene Bmal1. The authors now considerably extend these findings with demonstration that all members REV-ERB (α β) ROR (α, β, γ) families repress activate Bmal1 transcription, respectively. further show is competition between REV-ERBs RORs at specific response elements (RORE). Moreover, they...
Three isoforms of a novel member the steroid hormone nuclear receptor superfamily related to retinoic acid receptors have been identified. The three isoforms, referred as ROR alpha 1, 2, and 3, share common DNA- putative ligand-binding domains but are characterized by distinct amino-terminal generated alternative RNA processing. An exon encoding functionally important subregion domain 2 isoform resides on opposite strand cytochrome c-processed pseudogene. Binding site selection using in...
Estrogen-related receptors (ERRs) are orphan nuclear activated by the transcriptional coactivator peroxisome proliferator-activated receptor γ (PPARγ) 1α (PGC-1α), a critical regulator of cellular energy metabolism. However, metabolic target genes downstream ERRα have not been well defined. To identify ERRα-regulated pathways in tissues with high demand such as heart, gene expression profiling was performed primary neonatal cardiac myocytes overexpressing ERRα. upregulated subset PGC-1α...
Nuclear receptors can activate diverse biological pathways within a target cell in response to their cognate ligands, but how this compartmentalization is achieved at the level of gene regulation poorly understood. We used genome-wide analysis promoter occupancy by estrogen receptor α (ERα) MCF-7 cells investigate molecular mechanisms underlying action 17β-estradiol (E 2 ) controlling growth breast cancer cells. identified 153 promoters bound ERα presence E . Motif-finding algorithms...
AbstractThe transcriptional coactivator PGC-1α is a key regulator of energy metabolism, yet little known about its role in control substrate selection. We found that physiological stimuli to induce expression skeletal muscle coordinately upregulate the pyruvate dehydrogenase kinase 4 (PDK4), negative glucose oxidation. Forced C2C12 myotubes induced PDK4 mRNA and protein expression. PGC-1α-mediated activation was shown occur at level mapped putative nuclear receptor binding site. Gel shift...