A5051335790- Microbial Natural Products and Biosynthesis
- Cancer therapeutics and mechanisms
- Plant biochemistry and biosynthesis
- MicroRNA in disease regulation
- Alkaloids: synthesis and pharmacology
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Pharmacogenetics and Drug Metabolism
- Multiple Myeloma Research and Treatments
- Photosynthetic Processes and Mechanisms
- Phytochemistry and Biological Activities
- Fungal Biology and Applications
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Synthetic Organic Chemistry Methods
- Ubiquitin and proteasome pathways
- Bone health and osteoporosis research
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Ginger and Zingiberaceae research
- Traditional and Medicinal Uses of Annonaceae
- Advanced Nanomaterials in Catalysis
- Hedgehog Signaling Pathway Studies
Sichuan Agricultural University
2019-2025
Henan Cancer Hospital
2020-2025
Zhengzhou University
2012-2025
Guizhou University
2020-2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Science and Technology Department of Sichuan Province
2023-2024
Weatherford College
2024
Credo Reference (United States)
2024
Chinese Academy of Sciences
2012-2023
Due to the lack of a general descriptor predict activity nanomaterials, current exploration nanozymes mainly depended on trial-and-error strategies, which hindered effective design nanozymes. Here, with help large number Ni–O–Co bonds at interface heterostructures, prediction was successfully determined reveal double enzyme-like mechanisms for Ni/CoMoO4. Additionally, DFT calculations revealed that engineering could accelerate catalytic kinetics activity. were main active sites Finally,...
Background: Limited information is available about the prevalence of hepatitis C virus in patients with human immunodeficiency relation to specific risk factors or influence coinfection on survival. This retrospective study addressed these questions. Methods: The population consisted 512 predominantly non–intravenous drug–using male homosexuals, 224 whom had AIDS. Samples positive for antibody by second–generation enzyme immunoassay were further tested means strip immunoblot assay, and RNA...
A new p-terphenyl 1 and a novel derivative 3 bearing benzothiazole moiety were isolated from halophilic actinomycete Nocardiopsis gilva YIM 90087, along with known 2, antibiotic novobiocin 4, cyclodipeptides 5–13, aromatic acids 14 15. Their structures elucidated on the basis of interpretation spectral data by comparison corresponding those reported previously. The showed antifungal activity against three pathogenic fungi, including Fusarium avenaceum, graminearum, culmorum, that caused head...
Abstract Background Rectal cancer is one of the most prevalent tumor types. Understanding metabolic profile rectal important for developing therapeutic approaches and molecular diagnosis. Methods Here, we report a metabonomics profiling tissue samples on large cohort human subjects (n = 127) normal controls 43) using 1 H nuclear magnetic resonance ( NMR) based assay, which highly sensitive non-destructive method biomarker identification in biological systems. Principal component analysis...
Abstract Background The biomarker identification of human esophageal cancer is critical for its early diagnosis and therapeutic approaches that will significantly improve patient survival. Specially, those involves in progression disease would be helpful to mechanism research. Methods In the present study, we investigated distinguishing metabolites tissues (n = 89) normal mucosae 26) using a 1 H nuclear magnetic resonance ( H-NMR) based assay, which highly sensitive non-destructive method...
In a previous hit-to-lead research program targeting anticancer agents, two promising lead compounds, 1a and 1b, were found. However, the poor solubility of 1b made difficult further in vivo studies. To solve this problem, optimization was conducted through introducing N-methyl-piperazine groups at 2-position 6-position. our delight, optimized analogue 1d showed comparable antiproliferative activity vitro with better solubility, compared 1a. Based on result, replacement benzothiazole...
Abstract The construction of vicinal, congested stereocenters with high selectivities is general utility in chemistry. To build two such one step from readily available starting materials very desirable, but remains challenging. We report here a doubly stereoconvergent, Cu/Mg-catalyzed asymmetric propargylic substitution reaction to convert simple products vicinal tertiary and all-carbon quaternary yields excellent diastereo- enantioselectivities. Both the nucleophiles electrophiles employed...
Thunder god vine, the dried roots of Tripterygium wilfordii, is a widely used traditional Chinese medicine. More than 200 bioactive complex natural products have been isolated from this herb. Inspired by diversity chemical structures and bioactivities components herb, investigation to mine new entities as potential drug leads led identification 36 nitrogen-containing compounds. Among them, 18 dihydro-β-agarofuran alkaloids (tripterygiumines A−L (1−12), M−Q (22−26), R (33)) were identified...
Methods to diversify indolizines are valuable for the discovery of medications and fluorescent molecules. The utilization copper-catalyzed asymmetric propargylation install a terminal alkyne handle on indolizine heterocycle is reported. This method delivers C3-propargylation products from C2-substituted or C1-propargylation C2,C3-disubstituted through stereoconvergent pathway.
Treatments with abiotic elicitors can efficiently induce the accumulation of specialized metabolites in plants. We used a combined omics approach to analyze elicitation effects MeJa, AgNO 3 , and PEG on camptothecin (CPT) biosynthesis Camptotheca acuminata plantlets. Untargeted analyses revealed that treatments significantly inhibited photosynthetic pathway promoted carbon metabolism secondary metabolic pathways. The CPT levels increased by 78.6, 73.3, 50.0% treatment groups, respectively....
The detailed metabolic map for camptothecin (CPT) biosynthesis in Camptotheca acuminata has been proposed according to our combined omics results. However, the CYP450-mediated epoxidation step CPT remains unexplored. A proteomics-guided approach was used identify and annotate proteins enriched during vigorous metabolism period mature C. seedlings. Comparative analyses revealed that flavonoid biosyntheses were stems all of samples except leaves, respectively. CYP71BE genes screened based on...
In Chinese herbal medicine, Tanshinone IIA (Tan-IIA) is one of the main compounds extracted from Salvia miltiorrhiza Bunge. Tan-IIA has been demonstrated to inhibit growth various tumors. However, detailed molecular and cellular mechanisms antitumor effect have yet be fully illuminated.A2780 ID-8 were treated with 0, 1.2, 2.4, 4.8, or 9.6 µg/mL for 24 hours. Cell counting Kit-8 assay EdU staining used evaluate cell proliferation. Terminal deoxynucleotidyl transferase dUTP nick end labeling...
The present study aimed to investigate the protective effects and molecular mechanisms of Dendrobium officinale polysaccharides on gastric mucosal injuries. Following one week continuous intragastric administration, a injury model was established using administration anhydrous ethanol. area ulcer measured, contents interleukin- 6 (IL-6), epidermal growth factor receptor (EGFR), thyroid transcription 1 (TFF-1) in serum were detected by enzyme linked immunosorbent assay (ELISA), expressions...
Spontaneous senile osteoporosis severely threatens the health of senior population which has emerged as a severe issue for society. A SAMP6 mouse model was utilized to estimate impact intragastrically administered Astragalus Membranaceus (AR) on spontaneous osteoporosis. Bone mineral density (BMD) and bone microstructure were measured using Micro-CT; contents calcium phosphorus determined with colorimetric method; gene protein expressions fibroblast growth factor 23 (FGF23), Klotho, Vitamin...
Abstract Studies have reported that miR-204-5p is involved in multiple biological processes. However, little known about the expression and mechanism of cerebral ischemia reperfusion injury. This study found was significantly downregulated blood patients with ischemic stroke, MCAO/R rat brains, OGD/R neurons. Overexpression markedly reduced infarct volume neurological impairment alleviated inflammatory response vivo. promoted neuronal viability apoptotic cells vitro. Mechanically, negatively...