A5007842085- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Osteoarthritis Treatment and Mechanisms
- Nuclear Receptors and Signaling
- Shoulder Injury and Treatment
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Venous Thromboembolism Diagnosis and Management
- Musculoskeletal synovial abnormalities and treatments
- Cancer Immunotherapy and Biomarkers
- Pelvic and Acetabular Injuries
- Biochemical and Structural Characterization
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Spinal Fractures and Fixation Techniques
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Intestinal Malrotation and Obstruction Disorders
- Orthopedic Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Pediatric Hepatobiliary Diseases and Treatments
Guizhou Provincial People's Hospital
2017-2025
Sheng Jing Hospital
2020-2025
Ludong University
2024-2025
Zhongshan People's Hospital
2025
Jiangsu University
2024
Yancheng First People's Hospital
2021-2024
Nantong University
2021-2024
Wuxi People's Hospital
2024
Nanjing Medical University
2024
Nanjing University
2024
Introduction of Gadolinium (Gd) to the nervous system is linked development neurotoxicity involving both oxidative and endoplasmic reticulum (ER) stress. Gd levels (0.2-20 μm) in form gadolinium trichloride (GdCl(3)) cause vitro. We investigated signaling pathways primary cultured rat cortical neurons tested whether GdCl(3) induced ER Results showed that Gd-induced neural cell death followed a rapid accumulation intracellular reactive oxygen species. In addition, exposure resulted spliced...
Summary Aims Manganese superoxide dismutase ( M n SOD ), one of the most crucial antioxidant enzymes in central nervous system, is thought to be major mechanisms by which cells counteract injuries reactive oxygen species after cerebral ischemia. In this study, we used a novel synthesized compound T m4 P y ) with highly effective activity study therapeutic potential and possible underlying Methods Primary cultured cortical neurons were examine protective effect compounds. Mice middle artery...
Apocynum venetum leaves are used as a kind of phytomedicine and the main ingredient in some traditional Chinese medicine products for relief colitis. To understand bioactive constituents A. L., we did phytochemistry study investigated anti-Inflammatory effects compounds explored underlying mechanisms.We isolated from ethanol extract L. leaf detected most effective compound by NO inhibition assay. We on dextran sulfate sodium (DSS)-induced colitis mice lipopolysaccharide (LPS)-stimulated...
Nowadays, cancer is still a leading public health problem all over the world. Several studies have reported GPX8 could be correlated with poor prognostic of Gastric Cancer and Breast Cancer. However, potential in pan-cancer remains unclear. In this work, we aimed to explore immunological role human confirm oncogenic value GBM.The data TCGA, CPTAC GEO databases were adopted for survival analysis. Based on RNAseq Methylation450 R language package "ggplot2" used analyze DNA methylation at...
We previously demonstrated oxymatrine, an alkaloid from the Chinese medicine radix Sophorae flavescentis, ameliorates hemodynamic disturbances and cardiac fibrosis; however, underlying mechanisms are unclear. Here, we investigated effect mechanism of action oxymatrine on aldosterone-induced fibroblast to myofibroblast differentiation in vitro. Cardiac fibroblasts were isolated purified neonatal Sprague Dawley rats. The optimal concentration aldosterone stimulate proliferation was determined...
Early detection of a tumour remains an unmet medical need, and approaches with high sensitivity specificity are urgently required. Mass cytometry time-of-flight (CyTOF) is powerful technique to profile immune cells could be applied detection. We attempted establish diagnostic models for hepatocellular carcinoma (HCC) pancreatic ductal adenocarcinoma (PDAC).We performed CyTOF analysis 2348 participants from 15 centres, including 1131 hepatic diseases, 584 diseases 633 healthy volunteers....
Background: Integrating comprehensive information on hepatocellular carcinoma (HCC) is essential to improve its early detection. We aimed develop a model with multi-modal features (MMF) using artificial intelligence (AI) approaches enhance the performance of HCC Materials and methods: A total 1,092 participants were enrolled from 16 centers. These allocated into training, internal validation, external validation cohorts. Peripheral blood specimens collected prospectively subjected mass...
Objective: Cognitive impairment and depression significantly reduce quality of life in the aging population. This study aimed to investigate prevalence depressive symptoms cognitive explore its relationship elderly. Methods: A total 1645 elderly people nursing homes 4703 community were enrolled survey. The Patient Health Questionnaire-9 Ascertain Dementia-8 employed evaluate impairment. Results: overall was 12.5% community-dwelling group 52.2% home group. higher than that groups for same age...
Cationic antimicrobial peptides have attracted increasing attention as a novel class of antibiotics to treat infectious diseases caused by pathogenic bacteria. However, susceptibility protease is shortcoming in their development. Cyclization one approach increase the proteolytic resistance peptides. Therefore, improve Polybia‐MPI, we synthesized MPI cyclic analogs C‐MPI‐1 (i‐to‐i+4) and C‐MPI‐2 (i‐to‐i+6) copper(I)‐catalyzed azide–alkyne cycloaddition. Compared with MPI, displayed sustained...
JS001 (toripalimab) is a humanized IgG monoclonal antibody which strongly inhibits programmed cell death protein 1 (PD1). In this study, we used different iodine isotype (nat/124/125I) to label probes target the human PD1 (hPD1) antigen. vitro, half maximal effective concentration (EC50) value of natI-JS001 did not significantly differ from that JS001. The uptake 125I-JS001 by activated T cells was 5.63 times higher than nonactivated after 2 h incubation. binding affinity lineages...
The dysbiosis of intestinal microecology plays an important pathogenic role in the development inflammatory bowel disease.A polysaccharide named Fuc-S, with a molecular weight 156 kDa, was prepared by ultrasonic degradation fucoidan. Monosaccharide composition, FTIR, methylation, and NMR spectral analysis indicated that Fuc-S may have backbone consisting →3)-α-L-Fucp-(1→, →4)-α-L-Fucp-(1→ →3, 4)-α-D-Glcp-(1→. Moreover, male C57BL/6 mice were fed three cycles 1.8% dextran sulfate sodium (DSS)...
Melatonin (N‑acetyl‑5‑methoxytryptamine; MT) has been shown to have a protective effect against sepsis‑induced renal injury, however, the mechanisms underlying function of MT remain be elucidated. Therefore, in present study, potential preventive role injury were investigated. Hematoxylin and eosin staining was used detect on reduction tissue damage, immunohistochemistry (IHC), ELISA western blot analysis performed determine influence protein expression PTEN‑induced putative kinase 1...
Quantum dots (QDs) encapsulated with high affinity ligands, specifically binding organic such as antibodies, peptides or small molecules, have been used in intracellular imaging and targeting. In this work, a series of folate-receptor targeted QDs, which tumor-targeting folic acid (FA) was conjugated to the surface QDs through cell-penetrated γ-cyclodextrin (γ-CD), synthesized. The showed good optical properties biocompatibility, strong emission, long luminescent lifetime, appropriate size...