A5101826130- Inflammatory Bowel Disease
- Gut microbiota and health
- Polysaccharides and Plant Cell Walls
- Natural Antidiabetic Agents Studies
- Cardiac Fibrosis and Remodeling
- Berberine and alkaloids research
- Medicinal Plants and Bioactive Compounds
- Hydraulic Fracturing and Reservoir Analysis
- Rock Mechanics and Modeling
- Nanoparticle-Based Drug Delivery
- Signaling Pathways in Disease
- Microbial Metabolites in Food Biotechnology
- Traumatic Brain Injury and Neurovascular Disturbances
- Landslides and related hazards
- Kidney Stones and Urolithiasis Treatments
- Immune cells in cancer
- Phytochemistry and Biological Activities
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Geothermal Energy Systems and Applications
- CO2 Sequestration and Geologic Interactions
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
Fourth Affiliated Hospital of Guangxi Medical University
2025
Wuhan University of Science and Technology
2025
Wuhan University
2025
Wuhan Asia Heart Hospital
2025
Peking University Shenzhen Hospital
2018-2025
Leshan Normal University
2024
Chengdu University of Technology
2023-2024
Shenzhen University Health Science Center
2018-2023
Guiyang Medical University
2007-2023
Tianjin Medical University
2017-2023
The therapeutic effect of corilagin (1) was evaluated in an acute colitis model induced by dextran sulfate sodium (DSS) mice, and the mechanism action investigated this study. Animals were challenged with 2% DSS drinking water for 5 consecutive days then intraperitoneally treated 1 (7.5, 15, 30 mg/kg) daily 7 days. It found that significantly decreased disease activity index, inhibited shortening colon length, reduced tissue damage, suppressed myeloperoxidase activity. Moreover, greatly...
11 potential α-glucosidase inhibitors in leaves of<italic>Cyclocarya paliurus</italic>were quickly identified by UF-UPLC-Q/TOF-MS/MS, and their inhibitory activities were verified<italic>in vitro</italic>and<italic>in vivo</italic>, as well docked with homology model.
In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from Chinese natural resources, eight isoquinoline alkaloids, tetrahydropalmatine (1), corydaline (2), protopine (3), berberine (4), palmatine (5), jatrorrhizine (6), coptisine (7) and dehydrocorydaline (8), were isolated the methanolic extract of tubers Corydalis yanhusuo. Structures these compounds identified by spectroscopic techniques. Compounds 4–8 inhibited AChE activity in dose-dependent manner, IC50 values 0.47 ±...
To protect against oxidative stress‐induced apoptosis in lens epithelial cells is a potential strategy preventing cataract formation. The present study aimed at studying the protective effect and underlying mechanisms of p ‐coumaric acid ( ‐CA) on hydrogen peroxide‐ (H 2 O ‐) induced human (HLE) (SRA 01–04). Cells were pretreated with ‐CA concentration 3, 10, 30 μ M before treatment H (275 M). Results showed that pretreatment significantly protected ‐induced cell death dose‐dependent manner,...
Automatic detection and alarm of abnormal electrocardiogram (ECG) events play an important role in ECG monitor system; however, popular classification models based on supervised learning fail to detect effectively. Thus, we propose anomaly framework (ECG-AAE) adversarial autoencoder temporal convolutional network (TCN) which consists three modules (autoencoder, discriminator, outlier detector). The ECG-AAE is trained only with normal data. Normal signals could be mapped into latent feature...
The complex network of fractures formed by randomly distributed natural in hot-dry rocks (HDRs) complicates the heat transfer regularity injected fluid. On basis fracture network, exploring characteristics fluid flow and as influenced different parameters helps enable efficient resource extraction effectively promotes construction diversified energy utilization structures. Accordingly, accounting for effect thermal shock on evolution permeability rock matrix, a thermo-hydro-mechanical (THM)...
Qing-dai powder (QDP), comprising Indigo naturalis (Qing-dai) and dried alum (Ku-fan), was used in Chinese medicine to treat the conditions associated with mucosal hemorrhage, such as ulcerative colitis (UC). This study aims investigate effects potential mechanism of QDP on dextran sulfate sodium (DSS)-induced acute mice examine regulatory macrophages.Seven- eight-week-old male C57BL/6 were challenged 2.0 % DSS drinking water for 5 days then colitic arbitrarily allocated into five groups (n...
Indigo naturalis (also known as Qing-dai, or QD), a traditional Chinese medicine, has been widely used an anticolitis regimen in the clinical practice of medicine. However, precise mechanisms behind its efficacy remain unknown. We investigated protective effects and associated molecular QD DSS-induced colitis mice. found that administration attenuated colon shortening, tissue damage, disease activity index during onset colitis. Moreover, significantly suppressed colonic MPO increased...
CYP2J2 as an endoplasmic reticulum (ER)-expressed vital cytochrome P450 isoform participates in the metabolism of endogenous polyunsaturated fatty acids. Its abnormal expression and function are closely related to progress cancer cardiovascular diseases. Herein, ER-targeting near-infrared (NIR) fluorescent probe ER-BnXPI was developed for monitoring activity, which possessed a high selectivity sensitivity toward among various CYP450 isoforms exhibited excellent subcellular localization ER....
Saffron petal (SP) is an agricultural byproduct in the process of crude drug saffron, accounting for 90% dry weight saffron flowers. To promote utilization SP food and pharmaceutical industries, its anti-inflammatory activities were evaluated on LPS-activated RAW 264.7 cells DSS-challenged colitic mice. The results indicated that extract had a notable effect alleviating clinical manifestations colitis, such as reduction body weight, improvement disease activity index, mitigation colon...
Abstract Oxymatrine (1), a component extracted from traditional Chinese herb Sophora japonica (Sophora flavescens Ait.), has been demonstrated to have variety of pharmacological actions. Abundant experimental evidence indicates that 1 may exert protective effect on the cardiovascular system. This study was designed explore possible role against myocardial fibrosis induced by acute infarction (AMI) and its modulation transforming growth factor beta (TGF-β1)-Smads signaling pathways. Rats with...
Ulcerative colitis (UC) is an intestinal condition, involving inflammatory response, apoptosis, and associated processes. As one of the traditional Chinese medicine treatments for UC, quercetin has received attention because it can attenuate inflammation. However, oral administration does not perform well in therapy. In this study, reactive oxygen species (ROS)-sensitive nanoparticles (Que@Gel-DA NPs) prepared by self-assembly polymerization were proposed treatment UC. Quercetin was...
The present study describes the preparation of a dodecapeptide YHWYGYTPQNVI (GE11)‑conjugated liposome bound with polyethylene glycol to enhance therapeutic effect resveratrol (RSV) in head and neck cancer cells. results indicated that (RSV)‑loaded GE11‑conjugated liposomes (RSV‑GL) exhibited high entrapment efficiency >95%, an active drug loading level 19.5% w/w. Release kinetics revealed RSV was released slow sustained manner from RSV‑GL RSV‑loaded (RSV‑L) nanoparticulate systems....
Zhen-Wu-Bu-Qi Decoction (ZWBQD), a traditional Chinese medicine formula comprising Poria, Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae, Zingiberis Recens, Codonopsis and Coptidis, is used for treating ulcerative colitis (UC). In previous study, we have reported ZWBQD mitigates the severity of dextran sulfate sodium (DSS)-induced in mice.In this aimed to understand systemic actions underlying mechanisms on experimental mice.We multi-omics techniques immunoblotting approach study...
The dysbiosis of intestinal microecology plays an important pathogenic role in the development inflammatory bowel disease.A polysaccharide named Fuc-S, with a molecular weight 156 kDa, was prepared by ultrasonic degradation fucoidan. Monosaccharide composition, FTIR, methylation, and NMR spectral analysis indicated that Fuc-S may have backbone consisting →3)-α-L-Fucp-(1→, →4)-α-L-Fucp-(1→ →3, 4)-α-D-Glcp-(1→. Moreover, male C57BL/6 mice were fed three cycles 1.8% dextran sulfate sodium (DSS)...
Melatonin (Mel) is an endogenous active molecule whose metabolism progress significantly influences its bioactivity. However, the detailed metabolic pathway of Mel in pathological state has not yet been fully illustrated. In this study, 16 metabolites cancer cells and human liver microsomes were identified, which seven novel newly discovered. Among them, 2-hydroxymelatonin (2-O-Mel), as major metabolite cells, was revealed for first time, different from found liver. Furthermore, CYP1A1/1A2-...
Intestinal barrier dysfunction is widely observed in patients with irritable bowel syndrome (IBS) and significantly contributes to the persistence of IBS symptoms. The association between gut dysbiosis pathogenesis IBS, as well its connection intestinal dysfunction, has been established. However, precise roles bacteria inducing underlying mechanisms remain unclear. In present study, we showed that microbiota-derived lithocholic acid (LCA) positively associated biomarkers IBS-D. We found...
A shed cave structure with a sand cushion is often used as protective for rockfall disasters. Because of the randomness and unpredictability disasters, cushions caves suffer multiple impacts from rockfalls. Aiming at problem rockfall, this paper uses three-dimensional discrete element method to study dynamic response on different heights. Before conducting large-scale simulation studies, input parameters in numerical model are verified data laboratory experiments. Analyzing results shows...