A5077556223- Cardiac Ischemia and Reperfusion
- Traditional Chinese Medicine Analysis
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Cell death mechanisms and regulation
- Atherosclerosis and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Anesthesia and Neurotoxicity Research
- Cardiac Fibrosis and Remodeling
- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- Tryptophan and brain disorders
- Corneal surgery and disorders
- Cancer, Hypoxia, and Metabolism
- Ocular Surface and Contact Lens
- Ginkgo biloba and Cashew Applications
- Lipid metabolism and disorders
- Neuropeptides and Animal Physiology
- Ginger and Zingiberaceae research
- FOXO transcription factor regulation
- Vitamin C and Antioxidants Research
- Cardiovascular Disease and Adiposity
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cholesterol and Lipid Metabolism
Guiyang Medical University
2015-2025
The First People's Hospital of Guiyang
2023
Guizhou University
2021-2023
Chongqing Medical University
2023
Affiliated Hospital of Guizhou Medical University
2014-2022
Guiyang College of Traditional Chinese Medicine
2021
Nanyang Medical College
2003-2011
Wan Fang Hospital
2006
Ten Chen Hospital
1986-2004
Abstract Background Depression is an independent risk factor for coronary artery disease. Autonomic instability may play a mediating or moderating role in this relationship; however not well understood. The objective of study was to explore cardiac autonomic function and arrhythmia depression, the correlation between depression severity Heart Rate Variability (HRV) related indices, prevalence arrhythmia. Methods Individuals (n = 53) with major as assessed by Diagnostic Statistical Manual...
Major depressive disorder (MDD) is an independent risk factor for coronary heart disease (CHD), and influences the occurrence prognosis of cardiovascular events. Although there evidence that antidepressants may be cardioprotective after acute myocardial infarction (AMI) comorbid with MDD, operative pathophysiological mechanisms remain unclear. Our aim was therefore to explore molecular escitalopram on apoptosis expression Bax Bcl-2 in a rat model depression during ischemia/reperfusion (I/R)....
Abstract Oxymatrine (1), a component extracted from traditional Chinese herb Sophora japonica (Sophora flavescens Ait.), has been demonstrated to have variety of pharmacological actions. Abundant experimental evidence indicates that 1 may exert protective effect on the cardiovascular system. This study was designed explore possible role against myocardial fibrosis induced by acute infarction (AMI) and its modulation transforming growth factor beta (TGF-β1)-Smads signaling pathways. Rats with...
There is an increased incidence of major depressive disorder (MDD) in individuals after myocardial infarction (MI), but the pathophysiological processes mediating this association are unclear. Our previous study demonstrated increase pro-apoptotic pathways myocardium and hippocampus MDD, which was reversed by venlafaxine. This aimed to attempt confirm effects apoptosis vulnerability markers on a model depression infarction.Rats were divided into four groups: sham (N = 8), 8, chronic mild...
While there is evidence that the development and course of major depressive disorder (MDD) symptomatology associated with vascular disease, are changes in energy utilization disorder, extent to which cerebral blood flow changed this condition not clear. This study utilized a novel imaging technique previously used coronary stroke patients, 320-slice Computed-Tomography (CT), assess regional (rCBF) those MDD examine pattern perfusion. Thirty nine participants symptoms (Hamilton Depression...
Background: Reportedly, there is a clear correlation between waist circumference (WC) and atrial fibrillation (AF). However, no specific discussion about the relationship WC non-valvular AF (NVAF) patients with heart failure. Our main purpose was to study WC, central obesity (CO), NVAF Methods: This retrospective cohort study. A total of 3,435 in First Affiliated Hospital Xinjiang Medical University from January 2015 December 2017 were enrolled. The targeted independent variable dependent CO...
Objectives Major depressive disorder is associated with progressive brain changes and frequently comorbid cardiovascular disease. There may be shared pathophysiological pathways between cerebral myocardial dysfunction that impact on apoptosis related proteins. Our aim was to examine behaviour of rats chronic mild stress (CMS), explore the expression Bax Bcl-xl in hippocampus myocardium, additionally evaluate effects venlafaxine these molecular mechanisms. Methods Rats were randomly divided...
BACKGROUND In China, the essential oil of fruit, Fructus Alpiniae zerumbet (FAZ), is used to treat cardiovascular diseases. Recent in vitro studies have shown that FAZ (EOFAZ) can protect endothelial cells from injury. Because prevalence diabetes mellitus and its effects on system, aim this study was investigate mechanism EOFAZ human umbilical vein (HUVECs) treated with high levels glucose vitro. MATERIAL AND METHODS The lactate dehydrogenase (LDH) leakage assay detect HUVEC Tumor necrosis...
Abstract Accumulating evidence indicates that the actin regulator cofilin is overactivated in Alzheimer’s Disease (AD), but whether this abnormality contributes to synaptic and cognitive impairments AD unclear. In addition, brain region cell types involved remain unknown. study, we specifically manipulate LIMK1, key protein kinase phosphorylates inactivates cofilin, hippocampus of APP/PS1 transgenic mice. Using local injections AAV virus containing LIMK1 under control CaMKIIα promoter, show...
To investigate the ameliorated effects of an extract Ginkgo biloba (GBE) on experimental cardiac remodeling in rats induced by acute infarction, and further explore mechanism concentrated myocardial type I collagen, transforming growth factor beta 1 (TGF-β1), matrix metalloproteinase 2 (MMP-2) 9 (MMP-9), provide data for clinical application GBE.Rats were divided into five groups (n = 20) as following: sham operation group (group A), infarction model B), + aspirin (10 mg/kg) treatment C),...
Objectives: While evidence that episodes of mania in bipolar I are associated with changes bioenergetic and regional cerebral blood flow (rCBF) velocity (rCBFV), both the regions extent these have not yet been defined. Therefore, we determined pattern perfusion patients using major depressive disorder (MDD) as positive controls healthy participants negative controls. Methods: 20 mania, together 22 MDD 24 volunteers, were recruited for this study. On all participants, Transcranial Doppler...
This paper aimed to probe changes in the default mode network (DMN) functional connectivity (DMNFC) of brain patients with insomnia disorder (ID) under resting state.A total 67 ID and graphically matched healthy controls were selected. Then, their general information was collected, followed by a psychological scale valuation. Resting state magnetic resonance imaging (rs-fMRI) scanning conducted. Subsequently, collected statistics processed, bilateral precuneus medial superior frontal gyrus...
Abstract To analyze the changing trend of CH and CRF values under different influencing factors in T2DM patients. A total 650 patients with were included. We discovered that course T2DM, smoking history, BMI, FBG, DR, HbA1c, TC, TG, LDL-C levels common risk for while HDL-C a protective factor. Analyzing according to diabetes, we as continued persist, gradually decreased. Moreover, increase FBG accumulation In addition, HbA1c (%) > 12, decreased most, falling by 1.85 ± 0.33 mmHg 1.28 0.69...
BACKGROUND:The thyroid hormone metabolite 3-iodothyronamine (T1AM) is rapidly emerging as promising compound of decreasing heart rate and lowering cardiac output. The aim our study was to fully understand the molecular mechanism T1AM on cardiomyocytes its potential targets in cardiovascular diseases. MATERIAL AND METHODS:We developed an vitro myocardial ischemia-reperfusion injury model AC-16 cells by hypoxia-reoxygenation injury. Cell viability detected using CCK-8 assay apoptosis flow...
This study investigated the potential effects of 3-iodothyronamine (T1AM) on myocardial ischemia reperfusion injury (MIRI) and underlying molecular mechanisms.A total 16 adult male Sprague-Dawley rats were randomly divided into 4 groups administered following: control [60% dimethyl sulfoxide (DMSO) 40% saline, pH 7.4], T1AM (25 mg/kg), (50 or (100 mg/kg). The rectal temperatures measured at different time points. A further 30 randomized following 3 (n=10 in each group): sham operation,...
To investigate the detailed mechanism of 3-iodothyronamine (T1AM) in cell apoptosis and programmed necrosis hypoxia/reoxygenation- (H/R-) induced H9C2 injury.Cardiomyocyte cells were cultured vitro for establishment cardiomyocyte H/R models. Cells randomly divided into four groups: control group, T1AM pretreatment (6 μm T1AM+H/R) group. The degree myocardial injury was determined by detection inhibition rate CCK8 lactic dehydrogenase (LDH) activity. Cell assessed through TUNEL assay flow...
Huangqi Liuyi decoction is a famous traditional Chinese medicine (TCM) that has been widely used in China for the management of diabetes since Song Dynasty. Today, it commonly treating diabetic nephropathy (DN). Our previous experimental studies have suggested mixture HQD, containing astragalus saponin, flavone, polysaccharide, and glycyrrhetinic acid, could be treatment DN to improve renal function. The objective this study was develop sensitive reliable high-performance liquid...
Patients with rheumatoid arthritis (RA) may be more susceptible to infection by coronavirus disease-19 (COVID-19) due immune system dysfunction. However, there are still insufficient treatment strategies for patients RA and COVID-19. Since Jingulian is a traditional Chinese medicine (TCM) anti-viral regulatory functions, our study aims explore the detailed mechanisms of in treating COVID-19.All components were retrieved from pharmacology databases. Then, series network pharmacology-based...
Background Previous studies revealed the connection between left atrial appendage peak flow velocity (LAA-PEV) and postoperative persistent fibrillation (AF) recurrence. Yet, this association is not necessarily generalizable to AF patients undergoing initial cryoballoon ablation due current gaps in literature. Methods We prospectively studied 74 consecutive individuals with a for first time January 2018 2020. Before ablation, LAA-PEV was documented by transesophageal echocardiography (TEE)....