A5101611579- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Cardiac Ischemia and Reperfusion
- FOXO transcription factor regulation
- Air Quality and Health Impacts
- Hormonal Regulation and Hypertension
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Anesthesia and Sedative Agents
- Phytochemistry and biological activities of Ficus species
- Sunflower and Safflower Cultivation
- Spinal Fractures and Fixation Techniques
- Total Knee Arthroplasty Outcomes
- Ultrasound in Clinical Applications
- Cancer Immunotherapy and Biomarkers
- Forest, Soil, and Plant Ecology in China
- Climate Change and Health Impacts
- Geological Modeling and Analysis
- Reservoir Engineering and Simulation Methods
- Botanical Studies and Applications
- Antimicrobial Peptides and Activities
Guiyang Medical University
2015-2025
Affiliated Hospital of Guizhou Medical University
2015-2025
Central South University
2021-2024
Shandong Provincial QianFoShan Hospital
2023
Shandong First Medical University
2023
People's Liberation Army 411 Hospital
2014
Shanghai Jiao Tong University
2009
Ruijin Hospital
2009
Shanghai Institute of Hypertension
2009
Shenyang Pharmaceutical University
2008
Accumulating evidence indicates a critical role for T cells and relevant cytokines in the pathogenesis of systemic lupus erythematosus (SLE). However, specific contribution together with related circulating disease organ involvement is still not clear. In current study, we investigated molecule expressions cytokine levels blood samples from 49 SLE patients 22 healthy control subjects. The expression HLA-DR costimulatory molecules on was evaluated by flow cytometry. Concentrations serum...
The calcium-binding protein S100A4 demonstrates important regulatory roles in many biological processes including tumorigenesis and inflammatory disorders such as allergy. However, the specific mechanism of contribution to allergic diseases awaits further clarification. To address effect on regulation mast cell activation its impact Bone marrow-derived cultured cells (BMMCs) were derived from wild-type (WT) or S100A4-/- mice for vitro investigation. WT induced develop a passive cutaneous...
The abnormal expression of tumor associated genes in pan-cancer is closely related to the clinicopathological features distinct cancer types. Thus, identifying role specific needed for developing effective anti-cancer strategies. However, function CD244 has not been fully understood. In this study, we explored profile across 33 types based on Cancer Genome Atlas project, Gene Expression Omnibus database, and other bioinformatics tools. We found down-regulated levels seven up-regulated two...
1 In the present study, we compared elastin and collagen content of thoracic aortic medial adventitial layers from Wistar-kyoto (WKY) spontaneously hypertensive rats (SHR). addition, effects losartan, an angiotensin II receptor antagonist, spironolactone, a mineralocorticoid on were determined. 2 Prehypertensive (4-week-old) (16-week-old) SHR randomly divided into three groups treated with either 0.9% NaCl, losartan (20 mg/kg per day) or spironolactone (200 day). for 12 16 weeks,...
BACKGROUND:The thyroid hormone metabolite 3-iodothyronamine (T1AM) is rapidly emerging as promising compound of decreasing heart rate and lowering cardiac output. The aim our study was to fully understand the molecular mechanism T1AM on cardiomyocytes its potential targets in cardiovascular diseases. MATERIAL AND METHODS:We developed an vitro myocardial ischemia-reperfusion injury model AC-16 cells by hypoxia-reoxygenation injury. Cell viability detected using CCK-8 assay apoptosis flow...
Two new ferulate compounds, amurenlactone A (1) and amurenamide (2), along with 11 known compounds have been isolated from the cortex of Phellodendron amurense. The structures were established based on 1D, 2D NMR mass spectral analyzes. identified by comparison authentic samples.
Can meteorological conditions modify the associations between NO2 and SO2 exposure congenital limb defects (CLDs) during first trimester of pregnancy?Increases in were consistently associated with higher risks CLDs pregnancy; both low- high-temperature high air humidity act synergistically two pollutants on CLDs.Animal studies have indicated are CLDs, but corresponding epidemiological limited equivocal conclusions. Meteorological closely connected to generation, diffusion, distribution even...
This study investigated the potential effects of 3-iodothyronamine (T1AM) on myocardial ischemia reperfusion injury (MIRI) and underlying molecular mechanisms.A total 16 adult male Sprague-Dawley rats were randomly divided into 4 groups administered following: control [60% dimethyl sulfoxide (DMSO) 40% saline, pH 7.4], T1AM (25 mg/kg), (50 or (100 mg/kg). The rectal temperatures measured at different time points. A further 30 randomized following 3 (n=10 in each group): sham operation,...
To investigate the detailed mechanism of 3-iodothyronamine (T1AM) in cell apoptosis and programmed necrosis hypoxia/reoxygenation- (H/R-) induced H9C2 injury.Cardiomyocyte cells were cultured vitro for establishment cardiomyocyte H/R models. Cells randomly divided into four groups: control group, T1AM pretreatment (6 μm T1AM+H/R) group. The degree myocardial injury was determined by detection inhibition rate CCK8 lactic dehydrogenase (LDH) activity. Cell assessed through TUNEL assay flow...
Background . The thyroid hormone metabolite 3-iodothyronamine (3-T1AM) is rapidly emerging as a promising compound in decreasing the heart rate and lowering cardiac output. aim of our study was to fully understand molecular mechanism 3-T1AM on cardiomyocytes its potential targets cardiovascular diseases. Materials Methods In study, we utilized RNA-Seq characterize gene expression H9C2 cells after treatment. Comparative transcriptome analysis, including ontology, signaling pathways, disease...
Objective To study the effect of safflower polysaccharide(SPS) on expression tumor metastasis related genes CD44 and autocrine motility factor(AMF) mRNA BALB/c mice bearing S180.Method AMF tissue was detected by Real-time PCR assay.Result detection found that SPS played a role in tumor-bearing mice.CD44 decreased tissues.Conclusion can inhibit which may lead to inhibition metastasis Key words: Safflower polysaccharide; CD44; Autocrine factor
Objective To explore the expression of HO-1 in dermal tissue rats with type Ⅱ diabetic foot ulcer and association between level healing.Methods Forty-five Wistar male healthy weight ranging from 250 to 350 g were randomly divided into 3 groups:the group(the DF group),the hyperbaric oxygen therapy group (or DFHBO or simply HBO group) normal control NC group),each consisting 15 animals.The mRNA transcription was detected by RT-PCR.The animals groups all raised high lipid feed (88.8％ basic...
Objectives: INS068 is a novel, soluble, and long-acting insulin analog. In this study, we evaluated the pharmacokinetics relative bioavailability of two formulations in healthy Chinese subjects: reference formulation packaged vials administered via syringe (R), test pen injector (T). Methods: A randomized, open-label, two-period, two-sequence crossover study was conducted with 24 subjects. Subjects were randomized subcutaneously abdomen at 0.4 U/kg or injection according to an open design....