A5023821326- Escherichia coli research studies
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Bacterial Genetics and Biotechnology
- Lipid Membrane Structure and Behavior
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Bacteriophages and microbial interactions
- Sphingolipid Metabolism and Signaling
- Ion Transport and Channel Regulation
- Genomics and Phylogenetic Studies
- Microbial Natural Products and Biosynthesis
- Viral gastroenteritis research and epidemiology
- Erythrocyte Function and Pathophysiology
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Health and Disease Prevention
- Calcium signaling and nucleotide metabolism
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Renin-Angiotensin System Studies
- Hydrogen's biological and therapeutic effects
- Renal cell carcinoma treatment
- Signaling Pathways in Disease
Gyeongsang National University
2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2025
Shanghai Jiao Tong University
2009-2022
Ruijin Hospital
2007-2022
Shanghai Institute of Hypertension
2007-2022
State Key Laboratory of Pollution Control and Resource Reuse
2020
Nanjing University of Science and Technology
2020
Shanghai Institutes for Biological Sciences
2007-2019
Chinese Academy of Sciences
2007-2019
The complete genome sequence of Geobacillus thermodenitrificans NG80-2, a thermophilic bacillus isolated from deep oil reservoir in Northern China, consists 3,550,319-bp chromosome and 57,693-bp plasmid. reveals that NG80-2 is well equipped for adaptation into wide variety environmental niches, including reservoirs, by possessing genes utilization broad range energy sources, encoding various transporters efficient nutrient uptake detoxification, flexible respiration system an aerobic branch...
In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Mitophagy was evaluated by measuring changes of flux, mitochondria DNA copy number, and mitophagy-related proteins including translocase outer mitochondrial membrane 20 (TOMM20), cytochrome c oxidase IV (COX IV), microtubule-associated protein 1 light chain 3B (LC3B), adaptor nucleoporin p62 HK2 cells,...
It has been demonstrated that serum/glucocorticoid regulated kinase 1 (SGK1) and the downstream transcription factor forkhead box O1 (FoxO1) plays a critical role in differentiation of T helper 17 cells/regulatory cells (Th17/Treg). In present study, we hypothesized this SGK1-FoxO1 signaling pathway is involved Th17/Treg imbalance target organ damage angiotensin II (AngII)-induced hypertensive mice. Results show SGK1 inhibitor EMD638683 significantly reversed renal dysfunction cardiac...
Dysferlin has recently been reported to participate in cell membrane repair muscle and other cells through lysosome fusion. Given that fusion is a crucial mechanism leads raft clustering, the present study attempted determine whether dysferlin involved this process its related signalling, explores underlying dysferlin-mediated bovine coronary arterial endothelial (CAECs). We found clustered macrodomains after Fas Ligand (FasL) stimulation as detected by confocal microscopy fraction...
ABSTRACT Shigella and pathogenic Escherichia coli are major causes of human infectious diseases responsible for millions cases diarrhea worldwide every year. A convenient rapid method to identify highly serotypes E. is needed large-scale epidemiologic study, timely clinical diagnosis, reliable quarantine the pathogens. In this a DNA microarray targeting O-serotype-specific genes was developed detect 15 , including sonnei ; flexneri type 2a; boydii types 7, 9, 13, 16, 18; dysenteriae 4, 8,...
The O-antigen moiety of the LPS is one most variable cell surface components Gram-negative bacterial outer membrane. Variation due to presence different sugars and sugar linkages. Here, it reported that a group Escherichia coli O serogroups (O17, O44, O73, O77 O106), Salmonella enterica serogroup : 6,14 (H), share common four-sugar backbone O-subunit structure, possess almost identical gene clusters. Whereas E. antigen does not have any substitutions, other antigens in this differ by...
It is well known that the mutation of TRP-ML1 (transient receptor potential-mucolipin-1) causes mucolipidosis IV, a lysosomal storage disease. Given nicotinic acid adenine dinucleotide phosphate (NAADP)-Ca(2+) release channel activity associated with TRP-ML1, present study was designed to test hypothesis NAADP regulates lysosome function via activation activity. Using preparations from wild-type (TRP-ML1(+/+)) human fibroblasts, reconstitution experiments demonstrated (0.01-1.0 μM) produced...
Periaortic arch adipose tissue (PAAT) plays critical roles in regulating vascular homeostasis; however, its anatomic features, developmental processes, and origins remain unclear. Approach Results: Anatomic analysis genetic lineage tracing of Wnt1 (wingless-type MMTV [mouse mammary tumor virus] integration site family member 1)-Cre+;Rosa26RFP/+ mice, Myf5 (myogenic factor 5)-Cre+;Rosa26RFP/+ SM22α-Cre+;Rosa26RFP/+ mice are performed, the results show that PAAT has unique processes...
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Endophytic fungi play a vital role in protecting and promoting the growth of their host plants. The diversity fungal endophytes has been documented across different plant species varies depending on factors such as host, ecological conditions, health status plant. We isolated endophytic from Prunus yedoensis trees with decay rates. A total 31 were decayed trees, while 33 obtained healthy trees. number exhibiting antifungal activities against wood was higher 10 showing activity compared to...
Acid sphingomyelinase (ASM) mediates the formation of membrane raft (MR) redox signalosomes in a process that depends on local acid microenvironment coronary arterial endothelial cells (CAECs). However, it is not known how this formed and maintained. The present study hypothesized lysosomal V1 H + -ATPase provides hospitable for activation ASM when lysosomes traffic fuse into cell membrane. Confocal microscopy showed pH change significantly affected MRs, with more fluorescent patches under...
Almost all Streptococcus pneumoniae (pneumococcus) capsule serotypes employ the Wzy-dependent pathway for their capsular polysaccharide (CPS) biosynthesis. The assembly of CPS repeating unit (RU) is first committed step in this pathway. wciN gene was predicted to encode a galactosyltransferase involved RU pneumococcus type 6B CPS. Herein, we provide unambiguous vitro biochemical evidence that encodes an α-1,3-galactosyltransferase catalyzing transfer galactosyl from UDP-Gal onto...
Glycoconjugate is one of the most efficacious and safest vaccines against bacterial pathogens. Previous studies glycoconjugates pathogen E. coli O157:H7 focused more on humoral responses they elicited. However, little was known about their cellular responses. In this study, we exploited a novel approach based protein N-linked glycosylation system to produce glycoconjugate containing Escherichia O-antigen linked with maltose-binding examined its in BALB/c mice. The transfer MBP confirmed by...
Objectives: The present study aimed to investigate the prevalence of smoking and environmental tobacco smoke (ETS), associated factors current among adults, their attitudes perceptions towards control. Methods: A population-based cross-sectional survey was conducted in 2012 using a self-reported questionnaire. representative sample adults aged 18–79 years collected Jilin Province Northeast China by multistage stratified random cluster sampling design. Descriptive data analysis conducted, 95%...
The triglyceride-glucose index (TyG index) is one of the surrogate markers insulin resistance, and high-sensitivity C-reactive protein (hsCRP) reflects systemic inflammation. Existing studies suggest that resistance or inflammation may be indicative cardiometabolic disease, but few existing have combined TyG levels before assessing multimorbidity. Our study data came from China Health Retirement Longitudinal Study (CHARLS). Participants in this were followed for 9 years, we used these to...
ABSTRACT Escherichia coli strains causing postweaning diarrhea (PWD) and edema disease (ED) in pigs are limited to a number of serogroups, with O8, O45, O138, O139, O141, O147, O149, O157 being the most commonly reported worldwide. In this study, DNA microarray based on O-antigen-specific genes all 8 E. as well 11 encoding adhesion factors exotoxins associated PWD ED, was developed for identification related serogroups virulence gene patterns. The method tested against 186 Shigella...