A5101983486- Myasthenia Gravis and Thymoma
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Meningioma and schwannoma management
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Autophagy in Disease and Therapy
- Insect Resistance and Genetics
- Hematopoietic Stem Cell Transplantation
- MicroRNA in disease regulation
- Fibroblast Growth Factor Research
- Insect symbiosis and bacterial influences
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Liver physiology and pathology
- Cell death mechanisms and regulation
- Radiopharmaceutical Chemistry and Applications
- Organ Transplantation Techniques and Outcomes
- Protease and Inhibitor Mechanisms
- Neurobiology and Insect Physiology Research
- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Birth, Development, and Health
- Protein Degradation and Inhibitors
- Ferroptosis and cancer prognosis
Dalian Medical University
2013-2024
Chongqing Medical University
2013-2024
Second Affiliated Hospital of Chongqing Medical University
2013-2024
Ruijin Hospital
2015-2024
Shanghai Jiao Tong University
2013-2024
Hanzhong People's Hospital
2024
Zhejiang University
2002-2022
Shanghai Chest Hospital
2015-2022
Ningbo University
2020-2022
Shanghai Pudong New Area Gongli Hospital
2021
In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Mitophagy was evaluated by measuring changes of flux, mitochondria DNA copy number, and mitophagy-related proteins including translocase outer mitochondrial membrane 20 (TOMM20), cytochrome c oxidase IV (COX IV), microtubule-associated protein 1 light chain 3B (LC3B), adaptor nucleoporin p62 HK2 cells,...
Abstract N6-methyladenosine (m6A) is the most abundant posttranscriptional modification of mRNA in eukaryotes. Recent evidence suggests that dysregulated m6A-associated proteins and m6A modifications play a pivotal role initiation progression diseases such as cancer. Here, we identified IGF2BP3 specifically overexpressed acute myeloid leukemia (AML), subtype associated with poor prognosis high genetic risk. required for maintaining AML cell survival an m6A-dependent manner, knockdown...
Fibroblast growth factor 9 (Fgf9) is a well-known that regulates bone development; however, its function in homeostasis still unknown. Previously, we identified point mutation the FGF9 gene (p.Ser99Asn, S99N) and generated an isogeneic knock-in mouse model, which revealed this loss-of-function impaired early joint formation was responsible for human multiple synostosis syndrome 3 (SYNS3). Moreover, newborn adult S99N mutant mice exhibited significantly increased mass, suggesting Fgf9 also...
With characteristic self-renewal and multipotent differentiation, cancer stem cells (CSCs) have a crucial influence on the metastasis, relapse drug resistance of gastric (GC). However, genes that participates in stemness GC not been identified.The mRNA expression-based index (mRNAsi) was analyzed with differential expressions GC. The weighted gene co-expression network analysis (WGCNA) utilized to build targeting differentially expressed (DEG) discover mRNAsi-related modules genes. We...
Acute myeloid leukemia (AML) is a clonal malignant proliferative blood disorder with poor prognosis. Ferroptosis, novel form of programmed cell death, holds great promise for oncology treatment, and has been demonstrated to interfere the development various diseases. A range genes are involved in regulating ferroptosis can serve as markers it. Nevertheless, prognostic significance these AML remains poorly understood. Transcriptomic clinical data patients were acquired from The Cancer Genome...
Minimal residual disease (MRD) is of the most important factor for predicting prognosis and guiding treatment acute lymphoblastic leukemia (ALL). In this study, we investigated prognostic significance leukemia-associated immunophenotypes (LAIPs) as assessment index MRD in 125 adult B-lineage ALL (B-ALL) patients by eight-color flow cytometry. The LAIPs could be identified 96% 81.6% with sensitivity 10(-4) 10(-5), respectively. MRD-negative status clearly predict a favorable 2-year...
The increasing number of babies conceived by in vitro fertilization and embryo transfer (IVF-ET) shifts concern from pregnancy outcomes to long-time health offspring. Maternal high estradiol (E2) is a major characteristic IVF-ET lasts throughout the first trimester pregnancy. fetal thyroid develops during this period may thus be affected exposure supra-physiological E2. aim study investigate whether E2 maternal environment increases risk dysfunction children born following IVF-ET.A...
The aim of this study was to investigate the biological functions and underlying mechanisms SIRT5 in clear cell renal carcinoma (ccRCC).SIRT5 expression data Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) were selected, correlations between various clinicopathological parameters analysed. ccRCC tissues examined using immunohistochemistry. Stable lines with knockdown established. In vitro vivo experiments conducted functional roles cellular biology ccRCC, including viability...
Vitellogenin (Vg) is precursor of vitellin. Here, we identified a Vg (NlVg) and two Vg-likes (NlVg-like1 NlVg-like2) in the brown planthopper, Nilaparvata lugens. Phylogenetic analyses showed that NlVg-like1 NlVg-like2 are not clustered with conventional insect Vgs associated vitellogenesis. Temporo-spatial expression NlVg transcript levels increased significantly 24 h after emergence were primarily expressed female adults. However, was during all stages, both genders. Tissue-specific three...
Mucins play a variety of roles; for example, in vertebrates, mucins lubricate epithelial surfaces and protect tissue from physical biological damage; however, knowledge insect is limited. Here, we identified an eggshell-related mucin-like protein, NlESMuc, the brown planthopper (BPH), Nilaparvata lugens. NlESMuc was specifically expressed follicular cells egg chambers ovarioles. RNA interference (RNAi) used to perform functional analysis NlESMuc. Adult female BPH with knockdown had...
Video-assisted thoracoscopic surgery (VATS) has been increasingly used in the management of thymic epithelial tumours. However, its oncological efficacy remains to be proved. The purpose this study is compare outcomes following versus open case-matched groups patients with early-stage tumours from Chinese Alliance for Research Thymomas (ChART) retrospective database. Between 1994 and 2012, a total 1087 who underwent UICC (Union International Cancer Control) pathological Stage I ChART...
Highlights•Young children born to OHSS women displayed the lower IQ than non-OHSS IVF children.•Maternal serum estradiol level on hCG administration day was negatively correlated with of offspring.•The prevalence low IQ(<80) 4.7 times higher in offspring.Ovarian hyperstimulation syndrome (OHSS) is a complication assisted reproductive technologies. We discovered that mothers reduced intelligence quotient (IQ). This reduction might be associated during early pregnancy. Clinician should use...
Graft-versus-host disease (GVHD) is the major complication after allogeneic bone marrow transplantation. Valproic acid (VPA) was described as a histone deacetylase inhibitor that had anti-inflammatory effects and reduced production of proinflammatory cytokines in experimental autoimmune models. Using well-characterized mouse models MHC-mismatched transplantation, we studied VPA on GVHD severity graft-versus-leukemia (GVL) activity. Administration significantly attenuated clinical GVHD,...
The aim of this study was to determine the computed tomography (CT) features potentially helpful for accurate staging and predicting resectability thymic epithelial tumors (TET).One hundred thirty-eight consecutive TET patients undergoing surgical resection from April 2010 November 2011 were prospectively entered into a database. All staged according Masaoka-Koga system. relationship between CT with tumor complete reviewed after surgery.Surgico-pathological stage I in 63, II 32, III IV 11...
To clarify whether arsenic could exert inhibitory effects on tumor cells in pleural effusions of patients with non-small cell lung cancer (NSCLC), 36 NSCLC effusion samples were collected from Changzheng Hospital and Ruijin Hospital, 2019 to 2022. The genotype epidermal growth factor receptor (
Abstract BACKGROUND The brown planthopper (BPH), Nilaparvata lugens , is the most destructive rice insect pest. To exploit potential target genes for applications in transgenic to control this sap‐sucking pest, three ferritin were functionally characterized study. RESULTS In study, genes, that is, 1 Heavy Chain ( NlFer1 ), 2 Light NlFer2 ) and soma Nlsoma‐Fer identified from BPH. Tissue‐specific analyses showed all highly expressed gut. Although double‐stranded RNA injection‐mediated...
Background. Renal cell carcinoma is one of the most common malignant tumors in urinary system, seriously affecting people’s health and life. This study aimed to evaluate clinical value multi-mode color Doppler flow imaging for diagnosis solid renal tumor. Methods. Sixty-six from 63 patients were examined by (CDFI), power (PDFI), superb microvascular (SMI), contrast-enhanced ultrasound (CEUS) before surgery. The diagnostic efficacy four methods was compared determining blood grade ring-like...
Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, induces distinct cellular responses via different downstream signaling pathways depending on cell type. To investigate biological function underlying molecular mechanism melanoma, we constructed knockout, RIG-I-overexpressing B16-F10 knockdown A375 melanoma lines, analyzed RIG-I-mediated change behavior cells spontaneous poly (I:C)-induced activation. Cell...
Lesions with a high uptake of 18F-fluorodeoxyglucose (18F-FDG) on positron emission tomography-computed tomography (PET-CT) can be benign and malignant. New radiotracers, such as the gallium 68 (68Ga)-labeled fibroblast activation protein inhibitor 4 (FAPI-04), could used to diagnose colorectal carcinoma. This study aimed evaluate efficacy 68Ga-FAPI-04 PET in differentiating from malignant 18F-FDG-avid lesions.An azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat tumor model was...