A5100394107- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Neuroscience and Neural Engineering
- Cancer-related molecular mechanisms research
- Physics of Superconductivity and Magnetism
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Natural product bioactivities and synthesis
- Functional Brain Connectivity Studies
- CRISPR and Genetic Engineering
- Superconductivity in MgB2 and Alloys
- Wheat and Barley Genetics and Pathology
- Neuroendocrine regulation and behavior
- Circular RNAs in diseases
- Nicotinic Acetylcholine Receptors Study
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Neurobiology and Insect Physiology Research
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2016-2025
South China Normal University
2025
University of Electronic Science and Technology of China
2024-2025
Gansu Agricultural University
2025
Shaanxi University of Chinese Medicine
2025
Tianjin Institute of Industrial Biotechnology
2025
Guangxi University of Science and Technology
2025
Fourth Affiliated Hospital of Guangxi Medical University
2025
Shanghai Maritime University
2016-2024
Free-standing aligned carbon nanotubes have previously been grown above 700 degreesC on mesoporous silica embedded with iron nanoparticles. Here, over areas up to several square centimeters were nickel-coated glass below 666 by plasma-enhanced hot filament chemical vapor deposition. Acetylene gas was used as the source and ammonia a catalyst dilution gas. Nanotubes controllable diameters from 20 400 nanometers lengths 0. 1 50 micrometers obtained. Using this method, large panels of can be...
Patterned growth of freestanding carbon nanotube(s) on submicron nickel dot(s) silicon has been achieved by plasma-enhanced-hot-filament-chemical-vapor deposition (PE-HF-CVD). A thin film grid was fabricated a wafer standard microlithographic techniques, and the PE-HF-CVD done using acetylene (C2H2) gas as source ammonia (NH3) catalyst dilution gas. Well separated, single nanotubes were observed to grow grid. The structures had rounded base diameters approximately 150 nm, heights ranging...
Abstract Background MicroRNAs (miRNAs) have been recently detected in the circulation of cancer patients, where they are associated with clinical parameters. Discovery profiling circulating small RNAs has not reported breast (BC), and was carried out this study to identify blood-based RNA markers BC outcome. Methods The pre-treatment sera 42 stage II-III locally advanced inflammatory patients who received neoadjuvant chemotherapy (NCT) followed by surgical tumor resection were analyzed for...
Significance Vascular complications are the main cause of morbidity and mortality in diabetic population. Clinical trials show a persistence benefit from early application intensive therapy for glycemic control patients, phenomenon referred to as metabolic memory. The mechanisms underlying memory not fully understood. In this study, using two groups type 1 patients with without development sets genomic DNAs collected 16–17 y apart same we showed persistency DNA methylation over time at key...
A high-resolution scanning superconducting quantum interference device microscopy study of tetragonal single-layer Tl 2 Ba CuO 6+δ films, deposited on tricrystal SrTiO 3 substrates, demonstrates the effect spontaneously generated half flux quanta. This observation shows that in addition to YBa Cu O 7 , order parameter symmetry is consistent with a d x - y pair state. result also rules out any bilayer or twinning effects and pairing incompatible fourfold rotational as system.
Renal cell carcinoma (RCC) is one of the leading causes cancer mortality. Characterization microRNA (miRNA) expression RCC will help disclose new pathogenic pathways in tumourigenesis and progression may lead to development molecular biomarkers target-specific therapies for diagnosis, prognostication treatment. With limitations test specificity ability detect novel miRNA other small non-coding RNAs (smRNAs), microarray RT-PCR techniques are being replaced by evolving deep-sequencing...
Abstract Introduction Structural MRI has long been used to characterize local morphological features of the human brain. Coordination patterns among regions, however, are not well understood. Here, we constructed individual‐level brain networks and systematically examined their topological organization long‐term test–retest reliability under different analytical schemes spatial smoothing, parcellation, network type. Methods This study included 57 healthy participants all completed two scan...
Abstract Major depression is a prevalent emotion disorder. Chronic stressful life in genetically susceptible individuals presumably major etiology that leads to neuron and synapse atrophy the limbic system. Molecular mechanisms underlying pathological changes remain elusive. Mice were treated by chronic unpredictable mild stress (CUMS) until they demonstrated depression-like behavior. GABA release medial prefrontal cortex was evaluated cell electrophysiology imaging. profiles related...
Cadmium (Cd) is a widespread soil contaminant threatening human health. As an ideal energy plant, sweet sorghum (Sorghum bicolor (L.) Moench) has great potential in phytoremediation of Cd-polluted soils, although the molecular mechanisms are largely unknown. In this study, key factors responsible for differential Cd accumulation between two contrasting genotypes (high-Cd one H18, and low-Cd L69) were investigated. H18 exhibited much higher ability uptake translocation than L69. Furthermore,...
Previous studies on the effects of protein kinase C (PKC) inhibitors intracellularly introduced into postsynaptic neuron long-term potentiation (LTP) in hippocampal CA1 region showed that given before tetanic stimulation they only blocked development maintenance phase LTP and after tetanus did not affect continued established LTP. We now report different results such experiments obtained by looking dose-effect relationship to making use a synergistic effect two together. used following three...
The output of the neuronal digital spikes is fulfilled by axonal propagation and synaptic transmission to influence postsynaptic cells. Similar transmission, spike on axon not secure, especially in cerebellar Purkinje cells whose spiking rate high. characteristics, mechanisms physiological impacts deceleration infidelity remain elusive. presumably initiated local currents that raise membrane potential threshold activating voltage-gated sodium channels (VGSC). We have investigated natures...
Accumulating evidence suggests that early improvement after two-week antidepressant treatment is predictive of later outcomes patients with major depressive disorder (MDD); however, whether this associated baseline neural architecture remains largely unknown.Utilizing resting-state functional MRI data and graph-based network approaches, study calculated voxel-wise degree centrality maps for 24 MDD at linked them changes in the Hamilton Rating Scale Depression (HAMD) scores two weeks...
Major depression is a prevalent mood disorder. Chronic stress presumably main etiology that leads to the neuron and synapse atrophies in limbic system. However, intermediate molecules from stresses neuronal atrophy remain elusive, which we have studied medial prefrontal cortices mice.The mice were treated by chronic unpredictable mild (CUMS) until they expressed depression-like behaviors confirmed tests of sucrose preference, forced swimming Y-maze. High-throughput sequencings microRNA mRNA...
Dysregulated histone methyltransferase G9a may represent a potential cancer therapeutic target. The roles of in tumorigenesis and therapeutics are not well understood non-small cell lung (NSCLC). Here we investigated the impact on tumor growth signaling pathways NSCLC.Immunohistochemistry analyzed expression NSCLC tissues. Both siRNA selective inhibitor were used to target G9a. targeting key genes, cells by RNA sequencing analysis, rescue experiments, xenograft models.Overexpression (≥ 5%...
Investigation of human CNS disease and drug effects has been hampered by the lack a system that enables single-cell analysis live adult patient brain cells. We developed culturing system, based on papain-aided procedure, for resected tissue removed during neurosurgery. performed transcriptomics over 300 cells, permitting identification oligodendrocytes, microglia, neurons, endothelial astrocytes after 3 weeks in culture. Using deep sequencing, we detected 12,000 expressed genes, including...