A5080795371- Reservoir Engineering and Simulation Methods
- RNA modifications and cancer
- Hydraulic Fracturing and Reservoir Analysis
- Cancer-related molecular mechanisms research
- Hydrocarbon exploration and reservoir analysis
- Enhanced Oil Recovery Techniques
- Advancements in Battery Materials
- Advanced Vision and Imaging
- Advanced Optimization Algorithms Research
- Finite Group Theory Research
- Simulation and Modeling Applications
- Computer Graphics and Visualization Techniques
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Advanced Computational Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- graph theory and CDMA systems
- Circular RNAs in diseases
- Coding theory and cryptography
- Grey System Theory Applications
- Pancreatic and Hepatic Oncology Research
- Fault Detection and Control Systems
- RNA Research and Splicing
Sun Yat-sen Memorial Hospital
2019-2025
Sun Yat-sen University
2018-2025
Southeast University
2008-2024
Nanchang University
2024
Weifang University
2020-2024
Second Affiliated Hospital of Nanchang University
2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2023
Jiangxi University of Science and Technology
2018-2022
Beijing University of Posts and Telecommunications
2022
Shanghai Key Laboratory of Trustworthy Computing
2022
In the face of poor prognosis and immunotherapy failure gastric cancer (GC), this project tried to find new potential biomarkers for predicting precision medication ameliorate situation. To form synthetic matrices, we retrieved stomach adenocarcinoma transcriptome data from Genotype-Tissue Expression Project (GTEx) The Cancer Genome Atlas (TCGA). Necroptosis-related prognostic lncRNA was identified by coexpression analysis univariate Cox regression. Then performed least absolute shrinkage...
The available targeted therapies for gastric cancer (GC) are still limited, so it is important to discover novel molecules as potential treatment options. Proteins or peptides encoded by circular RNAs (circRNAs) increasingly reported play essential roles in malignancies. aim of the present study was identify an undiscovered protein circRNA and explore its key role molecular mechanism GC progression. CircMTHFD2L (hsa_circ_0069982) screened validated a downregulated with coding potential....
Abstract Targeted drug delivery and the reduction of off‐target effects are crucial for promising clinical application nucleic acid drugs. To address this challenge, a new approach treating osteoarthritis (OA) that accurately delivers antisense oligonucleotides (ASO) targeting matrix metalloproteinase‐13 (ASO‐MMP13) to chondrocytes, is developed. Small extracellular vesicles (exos) ligated with chondrocyte affinity peptide (CAP) using Sortase A subsequently incubated cholesterol‐modified...
Hepatocellular carcinoma (HCC) is one of the most aggressive malignant tumors, with a poor long-term prognosis worldwide. The functional deregulations global transcriptome were associated genesis and development HCC, but lacks systematic research validation. A total 519 postoperative HCC patients included. We built an interactive visual competing endogenous RNA network. prognostic signature was established least absolute shrinkage selection operator algorithm. Multivariate Cox regression...
Abstract Two aspects of deep mixing method, the difference relating strength gain in dry jet (DJM, reagent powder introduced into ground) and cement (CDM, slurry ground), prediction unconfined compressive stabilized marine clay, are discussed this paper. The first part paper concentrates on between DJM CDM gain, suggests a guideline for selection. An indicator terms water content ratio, which is defined as ratio to liquid limit soil, presented by statistical analysis from laboratory field...
The emergence of multi-drug resistant (MDR) microbes leads to urgent demands for novel antibiotics exploration. We demonstrated a cDNA from amphioxus Branchiostoma japonicum, designated Bjamp1, encoded protein with features typical antimicrobial peptides (AMPs), which is not homologous any AMPs currently discovered. It was found that Bjamp1 expressed in distinct tissues, and its expression remarkably up-regulated following challenge LPS LTA. Moreover, the synthesized putative mature AMP,...
Dietary fiber intake is associated with a low incidence of suffering from metabolic syndrome. To explore the potential health benefits walnut meal dietary (WMDF) as prebiotic, functional role WMDF on syndrome in mice induced by high fructose diet (20%, HF) was investigated. The animal experiment results showed that administration to HF-fed alleviated abnormal body weight gain, insulin resistance, oxidative stress, lipid metabolism disorders and inflammation. Histopathological observation...
Lymph node status and liver metastasis (LIM) are important in determining the prognosis of early colon carcinoma. We attempted to develop validate nomograms predict lymph (LNM) LIM patients with carcinoma.A total 32,819 who underwent surgery for pT1 or pT2 carcinoma were enrolled study based on their records SEER database. Risk factors LNM assessed univariate multivariate binary logistic regression. The C-index calibration plots used evaluate model discrimination. predictive accuracy...
Abstract Hepatitis B x protein (HBx) affects cellular expression and participates in the tumorigenesis progression of hepatitis virus (HBV)-related hepatocellular carcinoma (HCC). Metabolic reprogramming contributed to HCC development, but its role HBV-related remains largely unclear. Tyrosine-protein phosphatase nonreceptor type 13 (PTPN13) is a significant regulator tumor however, specific hepatocarcinogenesis be explored. Here, we found that decreased PTPN13 was associated with HBV/HBx....
The development of immunotherapy has enriched the treatment hepatocellular carcinoma (HCC), but efficacy is not as expected, which may be due to immune evasion. Immune evasion related microenvironment HCC, there little research on it. We employed unsupervised clustering analysis categorize patients from TCGA based 182 evasion-related genes (IEGs). utilized single-sample gene set enrichment (ssGSEA) and CIBERSORT calculate differences in cell infiltration between clusters. cells...
Long noncoding RNAs (lncRNAs) have been reported to regulate diverse tumorigenic processes. However, little is known about long intergenic non-protein coding RNA 00893 (LINC00893) and its role in gastric cancer (GC). Herein we investigated biological functions molecular mechanism GC. LINC00893 was decreased GC tissues but significantly elevated AGS cells after treatment with Nutlin-3. In patients, it found that low expression of correlated tumor growth, metastasis poor survival....
Hepatitis B virus X protein (HBx) is considered as an oncogene in tumorigenesis and progression of hepatocellular carcinoma (HCC). In recent years, the important role circular RNAs (circRNAs) HCC has been increasingly demonstrated. However, regulatory mechanisms HBx on circRNAs remains largely unknown. this study, we identified that a novel circRNA, circSFMBT2, was markedly downregulated by HBx. Low expression circSFMBT2 correlated with poor prognosis vascular invasion. Functionally,...