A5101980692- Cancer-related molecular mechanisms research
- Advanced Optical Sensing Technologies
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Retinal Diseases and Treatments
- Cervical Cancer and HPV Research
- Glaucoma and retinal disorders
- Random lasers and scattering media
- Robotics and Sensor-Based Localization
- Ferroptosis and cancer prognosis
- Photoacoustic and Ultrasonic Imaging
- Lattice Boltzmann Simulation Studies
- Optical Imaging and Spectroscopy Techniques
- Retinal and Macular Surgery
- Model Reduction and Neural Networks
- Cancer-related gene regulation
- Advanced Memory and Neural Computing
- RNA and protein synthesis mechanisms
- Advanced Fluorescence Microscopy Techniques
- Herpesvirus Infections and Treatments
- Optical measurement and interference techniques
- Robot Manipulation and Learning
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Human Pose and Action Recognition
- Cytomegalovirus and herpesvirus research
Wuhan University of Technology
2019-2025
ShanghaiTech University
2021-2024
Wenzhou Medical University
2020-2024
Central South University
2024
Southwest University
2020-2024
Technical University of Munich
2022-2024
Southeast University
2021-2023
Nanjing Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2020-2022
Zhejiang University
2021
Object pose estimation is crucial for robotic applications and augmented reality. Beyond instance level 6D object methods, estimating category-level shape has become a promising trend. As such, new research field needs to be supported by well-designed datasets. To provide benchmark with high-quality ground truth annotations the community, we introduce multimodal dataset photometrically challenging objects termed PhoCaL. PhoCaL comprises 60 high quality 3D models of household over 8...
Hypertension is a common risk factor for heart failure, and excessive angiotensin II (Ang II) leads to hypertensive cardiac alterations such as hypertrophy, fibrosis, remodeling, dysfunction. Leonurine the major active alkaloid compound obtained from traditional Chinese herbal medicine, Leonurus japonicus Houtt. The effects of leonurine on Ang II-induced injury remain unknown.In present study, we investigated cardioprotective in II-infused mice explored underlying mechanisms...
Abstract Protein drugs that neutralize vascular endothelial growth factor (VEGF), such as aflibercept or ranibizumab, rescue vision in patients with retinal diseases. Nonetheless, optimal visual outcomes require intraocular injections frequently every month. Here we report a method to extend the intravitreal half-life of protein an alternative either encapsulation chemical modifications polymers. We combine 97-amino-acid peptide human origin binds hyaluronan, major macromolecular component...
Introduction: Human basic fibroblast growth factor (hbFGF) is a highly valuable multifunctional protein that plays crucial role in various biological processes. In this study, we aim to accomplish the scaling-up production of mature hbFGF (146aa) by implementing high cell-density fermentation and purification process on 500-L scale, thereby satisfying escalating demands for both experimental research clinical applications. Methods: The DNA fragment was cloned into mpET-3c vector containing...
A noninvasive topical ocular therapy for the treatment of neovascular or "wet" age-related macular degeneration would provide a patient administered alternative to current standard care, which requires physician intravitreal injections. This manuscript describes novel strategy use in vivo models choroidal neovascularization (CNV) as primary means developing SAR related efficacy from administration. Ultimately, this effort led discovery acrizanib (LHA510), small-molecule VEGFR-2 inhibitor...
This paper provides a new avenue for exploiting deep neural networks to improve physics-based simulation. Specifically, we integrate the classic Lagrangian mechanics with autoencoder accelerate elastic simulation of deformable solids. Due inertia effect, dynamic equilibrium cannot be established without evaluating second-order derivatives network. is beyond capability off-the-shelf automatic differentiation packages and algorithms, which mainly focus on gradient evaluation. Solving nonlinear...
Abstract Research on the generation of manufacturing process problems in design has been conducted, and a method based multiple kernel Markov chains proposed. This utilizes sequential logical properties processing methods to establish chain generates subsequent previous methods. The engineering information is introduced into through functions from aspects part name, number, material, thermal surface treatment requirements. Compared with existing methods, this fully historical outline...
Analysing judicial documents is a significant task in the field of legal intelligence, which prediction law articles can help ordinary people better comprehend basic knowledge. It be seen as multi-label classification problem. Our work uses description cases input and views labels. After word segmentation feature extraction, classifier model TextCNN used to train predict results. Results comparative experiments show that our approach achieve competitive
Excessive vascular remodeling has been shown in hypertensive patients. In experimental models of injury, such as angiotensin II (Ang II) challenged mice, toll like receptor 2 (TLR2) initiates inflammatory responses. More recently, studies have reported atypical endothelial to mesenchymal transition (EndMT) injuries and conditions. Here, we aimed investigate whether TLR2 mediates Ang II-induced inflammation EndMT. a mouse model hypertension, show that aortas exhibit increased medial...
Abstract Background To rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC). Methods The RNA-sequence clinical information were from the TCGA GTEx databases. We operated Cox regression to determine signatures related overall survival (OS) recurrence-free (RFS) respectively. diagnostic effectiveness of prognostic further explored. Results identified nine ( VAMP7 , MTMR14 ATG4D KLHL24 TP73 NAMPT CD46 HGS ATG4C ) three risk SERPINA1 HSPB8 SUPT20H...
Abstract Continuing studies imply that m 6 A RNA modification is involved in the development of cervical cancer (CC), but lack strong support on recurrence and diagnosis prediction. In this research, a comprehensive analysis 33 regulators was performed to fulfill them. Here, we diagnostic prognosis models identified key regulators, respectively. Then CC patients were separated into two clusters accordance with participants cluster 1 had worse prognosis. Subsequently, AScore calculated...
Vascular remodeling is a pertinent target for cardiovascular therapy. smooth muscle cell (VSMC) dysfunction plays key role in vascular remodeling. Myeloid differentiation 2 (MD2), cofactor of toll-like receptor 4 (TLR4), involved atherosclerotic progress and cardiac via activation chronic inflammation. In this study, we explored the MD2 using an Ang II-induced mouse model cultured human aortic VSMCs. deficiency suppressed fibrosis phenotypic switching VSMCs without affecting blood pressure...
Abstract Emerging evidence indicates that hypoxia and immunity play important roles in tumorigenesis development. However, the hypoxia-immune-related prognostic risk model has not been established cervical cancer (CC). We aimed to construct a model, which potential application predicting prognosis of CC patients response targeted therapy. The RNA-seq data corresponding clinical information were retrieved from Cancer Genome Atlas (TCGA) database. status immune evaluated using Consensus...
ABSTRACT The coding capacity of human cytomegalovirus (HCMV) for glycoproteins by far exceeds that other herpesviruses. Few these proteins have been characterized so far. We investigated the gene product reading frame UL132. putative protein UL132 is a glycoprotein with theoretical mass 29.8 kDa. Transcription analysis revealed transcribed true late kinetics from laboratory-adapted strain AD169 and low-passage isolate TB40E. Two 22 to 28 kDa 45 60 were detected in virus-infected cells as...
Esophageal cancer (EC) is the seventh most common tumor in world, ranking sixth leading cause of death, with a 5-year survival rate 15-25%. Therefore, reliable prognostic biomarkers are needed to effectively predict prognosis EC. In this study, gene profile information EC cohort served as training set, which was derived from TCGA and Immport databases. GO KEGG enrichment analysis performed on differential genes normal groups The immune differentially expressed (DEGs) were further obtained...