A5100339075- GDF15 and Related Biomarkers
- Immune cells in cancer
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Nutrition and Health in Aging
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Phagocytosis and Immune Regulation
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Antimicrobial Peptides and Activities
- Kruppel-like factors research
- Cancer Immunotherapy and Biomarkers
- Antioxidant Activity and Oxidative Stress
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Reproductive System and Pregnancy
National Health and Family Planning Commission
2022-2025
Xi'an Jiaotong University
2022-2025
Northwest A&F University
2016-2025
Peking University
2012-2025
Peking University Third Hospital
2024-2025
Nanjing University of Chinese Medicine
2025
China Medical University
2017-2025
Beijing Chaoyang Emergency Medical Center
2025
Jinzhou Medical University
2025
West China Hospital of Sichuan University
2024
Copper (Cu) is a necessary micronutrient at lower concentration, while excessive Cu exposure or homeostasis disorders can lead to toxicity. The mechanism of male reproductive toxicity induced by still unknown. This study aims investigate whether autophagy plays an important role in copper-induced spermatogenesis disorder vivo and vitro. present showed that copper sulfate (CuSO4) might significantly promote level the testis mouse-derived spermatogonia cell line GC-1 spg cells. Concurrently,...
Abstract Carotenoids are a group of natural tetraterpenoid pigments with indispensable roles in the plant life cycle and human diet. Although carotenoid biosynthetic pathway has been well characterized, regulatory mechanisms that control metabolism, especially floral organs, remain poorly understood. In this study, we identified an anthocyanin-related R2R3-MYB protein, WHITE PETAL1 (WP1), plays critical role regulating pigmentation Medicago truncatula. Carotenoid analyses showed yellow...
Blood-brain barrier (BBB) disruption and dysfunction result in brain edema, which is responsible for more than half of all deaths after severe traumatic injury (TBI). Fibroblast growth factor 21 (FGF21) has a potential neuroprotective function the brain. However, effects underlying possible mechanism action on BBB integrity following TBI remain unknown. The purpose current study was to determine FGF21 protection treatment. recombinant human (rhFGF21) tight junction (TJ) adhesion (AJ)...
Abstract Extracellular matrix (ECM) stiffening is a typical characteristic of cartilage aging, which quintessential feature knee osteoarthritis (KOA). However, little known about how ECM affects chondrocytes and other molecules downstream. This study mimicked the physiological pathological stiffness human using polydimethylsiloxane (PDMS) substrates. It demonstrated that epigenetic Parkin regulation by histone deacetylase 3 ( HDAC3 ) represents new mechanosensitive mechanism affected...
Background and Purpose: Emerging evidence highlights the importance of IL33 (interleukin 33) its receptor (ST2 [interleukin 1 receptor-like 1]) in normal brains neurological disorders. This study explores function IL33/ST2 signaling axis a transcription factor STAT6 (signal transducer activator 6) white matter integrity long-term recovery after stroke. Methods: Transient middle cerebral artery occlusion was induced wild type, ST2 knockout, microglia/macrophage-depleted (by PLX5622 diet)...
Abstract Radiation enteritis is the most common complication of pelvic radiotherapy, but there no effective prevention or treatment drug. Apoptotic T cells and their products play an important role in regulating inflammation maintaining physiological immune homeostasis. Here it shown that systemically infused cell‐derived apoptotic extracellular vesicles (ApoEVs) can target mice irradiated intestines alleviate radiation enteritis. Mechanistically, elevates synthesis intestinal 2′3′ cyclic...
Angiogenesis of brain microvascular endothelial cells (BMECs) is required in the functional restoration injury, such as traumatic injury (TBI) and ischemic stroke. Fibroblast growth factor 21 (FGF21) an angiogenic molecule that functions through formation FGF21/FGFR1/β-klotho complex but does not cause carcinogenic events. The current study was to determine whether recombinant human FGF21 (rhFGF21) could promote angiogenesis scratch wound healing (HBMECs) possible underlying mechanism....
Elevated circulating levels of growth differentiation factor 15 (GDF15) have been shown to reduce food intake and lower body weight through activation hindbrain receptor glial-derived neurotrophic (GDNF) alpha-like (GFRAL) in rodents nonhuman primates, thus endogenous induction this peptide holds promise for obesity treatment. Here, silico drug-screening methods, we found that small molecule Camptothecin (CPT), a previously identified drug with potential antitumor activity, is GDF15 inducer....
Autophagy is a critical process to maintain homeostasis, differentiation, and development. How autophagy tightly regulated by nutritional changes poorly understood. Here, we identify chromatin remodeling protein Ino80 histone variant H2A.Z as the deacetylation targets for deacetylase Rpd3L complex uncover how they regulate in response nutrient availability. Mechanistically, deacetylates K929, which protects from being degraded autophagy. The stabilized promotes eviction autophagy-related...
Billions of apoptotic cells are swiftly removed from the human body daily. This clearance process is regulated by efferocytosis, an active anti-inflammatory during which phagocytes engulf and remove cells. However, impaired associated with development various autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease. In this review, we conducted a comprehensive search relevant studies published January 1, 2000, to present, focusing on disease...
Cognitive impairment is a common issue among human patients undergoing surgery, yet the neural mechanism causing this remains unidentified. Surgical procedures often lead to glial cell activation and neuronal hypoexcitability, both of which are known contribute postoperative cognitive dysfunction (POCD). However, role neuron-glia crosstalk in pathology POCD still unclear. Through integrated transcriptomics proteomics analyses, we found that complement cascades microglial phagocytotic...
To investigate the potential adverse effects of mobile phone radiation, we studied reactive oxygen species (ROS), DNA damage and apoptosis in mouse embryonic fibroblasts (NIH/3T3) after intermittent exposure (5 min on/10 off, for various durations from 0.5 to 8 h) an 1800-MHz GSM-talk mode electromagnetic radiation (EMR) at average specific absorption rate 2 W/kg. A 2′,7′-dichlorofluorescin diacetate fluorescence probe was used detect intracellular ROS levels, immunofluorescence γH2AX foci...