Hao Lin

ORCID: 0000-0003-4717-8335
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Research Areas
  • Aquaculture Nutrition and Growth
  • Plant Molecular Biology Research
  • Aquaculture disease management and microbiota
  • Plant Reproductive Biology
  • Physiological and biochemical adaptations
  • Plant Parasitism and Resistance
  • Chromosomal and Genetic Variations
  • Plant nutrient uptake and metabolism
  • MicroRNA in disease regulation
  • Plant tissue culture and regeneration
  • Legume Nitrogen Fixing Symbiosis
  • Plant biochemistry and biosynthesis
  • CRISPR and Genetic Engineering
  • Plant Virus Research Studies
  • Genetic and phenotypic traits in livestock
  • RNA modifications and cancer
  • Genetic Mapping and Diversity in Plants and Animals
  • Genomics and Phylogenetic Studies
  • Seed and Plant Biochemistry
  • Microbial Metabolites in Food Biotechnology
  • Metabolomics and Mass Spectrometry Studies
  • RNA and protein synthesis mechanisms
  • Bioenergy crop production and management
  • RNA Research and Splicing
  • Genetic diversity and population structure

Chinese Academy of Agricultural Sciences
2016-2025

Jimei University
2023-2025

Biotechnology Research Institute
2016-2025

Fujian Fisheries Research Institute
2023-2025

Hunan Normal University
2025

Sichuan University
2022-2024

Institute of Crop Sciences
2024

King's College London
2023

Shanghai University of Medicine and Health Sciences
2023

Sun Yat-sen University
2009-2022

Tillering in rice (Oryza sativa) is one of the most important agronomic traits that determine grain yields. Previous studies on tillering mutants have shown outgrowth tiller buds regulated by a carotenoid-derived MAX/RMS/D (more axillary branching) pathway, which may be conserved higher plants. Strigolactones, group terpenoid lactones, been recently identified as products pathway inhibits bud outgrowth. We report here molecular genetic characterization d27, classic mutant exhibiting...

10.1105/tpc.109.065987 article EN cc-by The Plant Cell 2009-05-01

The WUSCHEL related homeobox ( WOX ) genes play key roles in stem cell maintenance, embryonic patterning, and lateral organ development. have been categorized into three clades—ancient, intermediate, modern/WUS—based on phylogenetic analysis, but a functional basis for this classification has not established. Using the classical bladeless lam1 mutant of Nicotiana sylvestris as genetic tool, we examined function Medicago truncatula gene, STENOFOLIA STF ), controlling leaf blade outgrowth....

10.1073/pnas.1215376110 article EN Proceedings of the National Academy of Sciences 2012-12-17

Abstract Dicot leaf primordia initiate at the flanks of shoot apical meristem and extend laterally by cell division expansion to form flat lamina, but molecular mechanism lamina outgrowth remains unclear. Here, we report identification STENOFOLIA (STF), a WUSCHEL-like homeobox transcriptional regulator, in Medicago truncatula, which is required for blade vascular patterning. STF belongs MAEWEST clade its inactivation transposable element Nicotiana tabacum type1 (Tnt1) retrotransposon...

10.1105/tpc.111.085340 article EN cc-by The Plant Cell 2011-06-01

High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles ROS scavenging. In the present study, tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression NtMYB4 suppressed by salinity. Overexpression reduced salt tolerance transgenic repressed promoter activity NtCHS1 negatively regulated its expression. Rutin accumulation significantly decreased overexpressing plants RNAi silenced Moreover, high H2O2...

10.3389/fpls.2019.00178 article EN cc-by Frontiers in Plant Science 2019-02-21

Abstract Carotenoids are a group of natural tetraterpenoid pigments with indispensable roles in the plant life cycle and human diet. Although carotenoid biosynthetic pathway has been well characterized, regulatory mechanisms that control metabolism, especially floral organs, remain poorly understood. In this study, we identified an anthocyanin-related R2R3-MYB protein, WHITE PETAL1 (WP1), plays critical role regulating pigmentation Medicago truncatula. Carotenoid analyses showed yellow...

10.1105/tpc.19.00480 article EN cc-by The Plant Cell 2019-09-17

Double haploid (DH) technology, based on in vivo induction, enables the fixation of recombinant haplotypes within two generations, thereby greatly increasing crop breeding efficiency (Jacquier et al., 2020). Although plants can be produced from some legumes via an vitro anther/microspore culture approach (Croser 2006), (seed-based) induction system has not yet been established for this family, hindering application DH technology. Here, we report successful generation through seeds by editing...

10.1111/pbi.13740 article EN cc-by-nc-nd Plant Biotechnology Journal 2021-10-27

Abstract Background Tartary buckwheat, Fagopyrum tataricum , is a pseudocereal crop with worldwide distribution and high nutritional value. However, the origin domestication history of this remain to be elucidated. Results Here, by analyzing population genomics 567 accessions collected reviewing historical documents, we find that buckwheat originated in Himalayan region then spread southwest possibly along migration Yi people, minority Southwestern China has long planting buckwheat. Along...

10.1186/s13059-024-03203-z article EN cc-by Genome biology 2024-02-27

Abstract CRISPR/Cas is a simple, robust, versatile tool for plant biology studies and precision breeding. However, establishing high-efficiency gene editing system multiplex of the autotetraploid crop alfalfa ( Medicago sativa L.), most important forage legume worldwide, remains formidable challenge. Here, we systematically identified endogenous U6 promoters in through transient expression via Agrobacterium -mediated infiltration leaves. We further demonstrated efficacy three active genome...

10.1007/s42994-025-00200-z article EN cc-by aBIOTECH 2025-02-10

High soybean meal diet (HSBMD) decreased the immunity and damaged liver health of spotted sea bass; in this study, Lycium barbarum polysaccharides (LBP) was added to HSBMD explore its effects on health. The with 44% fish content designed as a blank control. On basis, used replace 50% HSBMD, LBP gradient (1.0, 1.5, 2.0 g/kg) experimental diet. 225-tailed bass initial body weight 44.52 ± 0.24 g were randomly divided into 5 groups fed corresponding for 52 days, respectively. results show that:...

10.3389/fimmu.2024.1333469 article EN cc-by Frontiers in Immunology 2024-02-06

Switchgrass (Panicum virgatum L.) is a dedicated lignocellulosic feedstock for bioenergy production. The SQUAMOSA PROMOTER-BINDING PROTEIN (SBP-box)-LIKE transcription factors (SPLs) change plant architecture and vegetative-to-reproductive phase transition significantly, as such, they are promising candidates genetic improvement of switchgrass biomass yield. However, the genome-wide identification functional characterization SPL genes have yet to be investigated in herbaceous energy crops.We...

10.1186/s13068-016-0516-z article EN cc-by Biotechnology for Biofuels 2016-05-05

Lignocellulosic biomass can be a significant source of renewable clean energy with continued improvement in yield and bioconversion strategies. In higher plants, the leaf blade is central convertor where solar CO2 are assimilated to make building blocks for production. Here we report that introducing development regulator STENOFOLIA (STF), WOX family transcription factor, into biofuel crop switchgrass, significantly improves both sugar release. We found STF overexpressing switchgrass plants...

10.1371/journal.pgen.1006649 article EN cc-by PLoS Genetics 2017-03-06

Alternative splicing (AS) is an important post-transcriptional regulatory mechanism for cells to generate transcript variability and proteome diversity. No systematic investigation of AS events among different tissues in response stressors available tilapia currently. In this study, was identified the cold stress-related were explored a Nile (Oreochromis niloticus) line based on 42 RNA-seq datasets using bioinformatics pipeline. 14,796 (82.76%; SD = 2,840) expression genes showed events. The...

10.3389/fgene.2020.00244 article EN cc-by Frontiers in Genetics 2020-03-18

Abstract Background Two widely cultivated annual buckwheat crops, Fagopyrum esculentum and F. tataricum , differ from each other in both rutin concentration reproductive system. However, the underlying genetic mechanisms remain poorly elucidated. Results Here, we report first haplotype-resolved chromosome-level genome assemblies of two species. haplotype genomes were assembled as 1.23 1.19 Gb with N50 = 9.8 12.4 Mb, respectively; 453.7 446.2 Mb 50 30 respectively. We further annotated...

10.1186/s12915-023-01587-1 article EN cc-by BMC Biology 2023-04-17

The identification and understanding of cryptic intraspecific evolutionary units (lineages) are crucial for planning effective conservation strategies aimed at preserving genetic diversity in endangered species. However, the factors driving evolution maintenance these lineages most species remain poorly understood. In this study, we conducted resequencing 77 individuals from 22 natural populations Davidia involucrata, a "living fossil" dove tree endemic to central southwest China. Our...

10.1016/j.pld.2024.02.004 article EN cc-by-nc-nd Plant Diversity 2024-02-12

Alfalfa (Medicago sativa. L.) is a globally significant autotetraploid legume forage crop. However, despite its importance, establishing efficient gene editing systems for cultivated alfalfa remains formidable challenge. In this study, we pioneered the development of highly effective ultrasonic-assisted leaf disc transformation system Gongnong 1 alfalfa, variety widely in Northeast China. Subsequently, created single transcript CRISPR/Cas9 (CRISPR_2.0) toolkit, incorporating multiplex gRNAs,...

10.1016/j.cj.2024.04.001 article EN cc-by-nc-nd The Crop Journal 2024-05-03

The study investigated the impact of chlorogenic acid (CGA) supplementation in a high-fat diet (HFD) on growth, lipid metabolism, intestinal and hepatic histology, as well gut microbiota spotted sea bass. A total 540 fish were fed six experimental diets, including normal fat (NFD), (HFD), HFD supplemented with 100, 200, 300, 400 mg/kg CGA (named HFD1, HFD2, HFD3, HFD4, respectively) for 7 weeks. results showed that feeding increased growth deposition compared to NFD group. Inclusion 300...

10.3390/metabo13101067 article EN cc-by Metabolites 2023-10-10
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