A5101405389- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- RNA modifications and cancer
- Plant Reproductive Biology
- Advanced Proteomics Techniques and Applications
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Fibroblast Growth Factor Research
- Photosynthetic Processes and Mechanisms
- Plant Virus Research Studies
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Mass Spectrometry Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Optical measurement and interference techniques
- Plant Disease Resistance and Genetics
- Plant and Fungal Interactions Research
- Advanced Measurement and Metrology Techniques
- Circular RNAs in diseases
- Mast cells and histamine
- Cholinesterase and Neurodegenerative Diseases
Emory University
2014-2025
Tianjin University
2022-2025
Beijing Sport University
2022-2024
Beijing Proteome Research Center
2020-2024
Hainan Tropical Ocean University
2024
Yunnan Agricultural University
2024
Forestry Research Institute
2015-2023
Beijing Institute of Education
2022-2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2022-2023
Capital Medical University
2014-2023
Article18 February 2019Open Access Transparent process A deep proteome and transcriptome abundance atlas of 29 healthy human tissues Dongxue Wang orcid.org/0000-0002-4402-0690 Chair Proteomics Bioanalytics, Technische Universität München, Freising, Germany Search for more papers by this author Basak Eraslan Computational Biology, Department Informatics, Technical University Munich, Garching bei Biochemistry, Quantitative Biosciences Gene Center, Ludwig Maximilian Universität, Thomas Wieland...
Abstract Background Resident microglia and macrophages are the predominant contributors to neuroinflammation immune reactions, which play a critical role in pathogenesis of ischemic brain injury. Controlling inflammatory responses is considered promising therapeutic approach for stroke. Recombinant human fibroblast growth factor 21 (rhFGF21) presents anti-inflammatory properties by modulating macrophages; however, our knowledge modulation rhFGF21 focal cerebral ischemia lacking. Therefore,...
Citrullination is a posttranslational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss positive charge may cause structural or functional alterations, and while the has been linked to several diseases, including rheumatoid arthritis (RA) cancer, its physiological pathophysiological roles remain largely unclear. In part, this owing limitations available methodology robustly enrich, detect, localize modification. As result, only few...
Article18 February 2019Open Access Transparent process Quantification and discovery of sequence determinants protein-per-mRNA amount in 29 human tissues Basak Eraslan Computational Biology, Department Informatics, Technical University Munich, Garching, Germany Graduate School Quantitative Biosciences (QBM), Ludwig-Maximilians-Universität München, Search for more papers by this author Dongxue Wang orcid.org/0000-0002-4402-0690 Chair Proteomics Bioanalytics, Freising, Mirjana Gusic Institute...
The oncogenic transcription factor MYC and its binding partner MAX regulate gene expression by to DNA at enhancer-box (E-box) elements 5΄-CACGTG-3΄. In mammalian genomes, the central E-box CpG has potential be methylated 5-position of cytosine (5mC), or undergo further oxidation 5-hydroxymethyl (5hmC), 5-formyl (5fC), 5-carboxyl (5caC) forms. We find that exhibits greatest affinity for a 5caC unmodified C-containing E-box, much reduced affinities corresponding 5mC, 5hmC 5fC Crystallization...
Background and Purpose Few studies have reported on the risk factors of dilated Virchow-Robin Spaces (dVRS) in large samples ischemic stroke patients. Little evidence exists regarding relationship between dVRS etiologic subtype or lacune. We aimed to investigate associated with severity a sample Methods consecutively enrolled 1,090 patients who experienced an within past seven days underwent 3.0 T MRI scan Chinese IntraCranial AtheroSclerosis Study (ICAS). Clinical data cranial information...
Angiogenesis of brain microvascular endothelial cells (BMECs) is required in the functional restoration injury, such as traumatic injury (TBI) and ischemic stroke. Fibroblast growth factor 21 (FGF21) an angiogenic molecule that functions through formation FGF21/FGFR1/β-klotho complex but does not cause carcinogenic events. The current study was to determine whether recombinant human FGF21 (rhFGF21) could promote angiogenesis scratch wound healing (HBMECs) possible underlying mechanism....
Microglia are immune cells in the central nervous system (CNS) that participate response to pathological process after ischemic injury. Non-mitogenic fibroblast growth factor 1 (nmFGF1) is an effective neuroprotective also known as a metabolic regulator. The present study aimed investigate effects and mechanism of ability nmFGF1 on microglia mice photothrombosis (PT) stroke model, determine whether it could ameliorate injury experiment. We discovered intranasal administration reduced infarct...
Gallic acid (GA) is a type of polyphenolic compound that can be found in range fruits, vegetables, and tea. Although it has been confirmed improves non-alcoholic fatty liver disease (NAFLD), still unknown whether GA improve the occurrence NAFLD by increasing low-density lipoprotein receptor (LDLR) accumulation alleviating cholesterol metabolism disorders. Therefore, present study explored effect on LDLR its mechanism action. The findings indicated increase HepG2 cells induced was associated...
Objectives This study aims to compare the protein composition of high-density lipoprotein (HDL) particles in coronary heart disease (CHD) patients and controls by proteomic methods. Background HDL has been reported exert pro-atherogenic properties CHD patients. Accumulating evidence indicates that composition, rather than HDL-C level, determines its functions. The changes involved conversion anti-atherogenic are currently unknown. Methods Results iTRAQ combined with nanoLC-MS/MS was...
Desorption of asphaltenes from silica-coated quartz crystals upon exposure to a series saline solutions was studied through the measurements crystal microbalance with dissipation (QCM-D), atomic force microscopy (AFM), and contact angle. Interestingly, it found that mass loading thickness asphaltene film decreased during injection sodium chloride solution at concentrations ranging 1 10 mM, surface tending be hydrophilic, whereas increased gradually when concentration 1000 inclined...
Activator protein 1 (AP-1) is a transcription factor that recognizes two versions of 7-base pair response element, either 5΄- GAG CA-3΄ or (where M = 5-methylcytosine). These elements share the feature 5-methylcytosine and thymine both have methyl group in same position, 5-carbon pyrimidine, so each them has groups at nucleotide positions 5 from 5΄ end, resulting four symmetrically positioned duplex DNA. Epstein-Barr Virus Zta key transcriptional regulator viral lytic cycle homologous to...
Maize anther ontogeny is complex, with the expression of more than 30,000 genes over 4 days cell proliferation, fate acquisition and start meiosis. Although many male-sterile mutants disrupt these key steps, few have been investigated in detail. The terminal phenotypes Zea mays (maize) male sterile 8 (ms8) are small anthers exhibiting meiotic failure. Here, we document much earlier defects: ms8 epidermal cells normal number but fail to elongate, there fewer, larger tapetal that retain,...
Double fertilization of flowering plants depends on the targeted transportation sperm to embryo sac by pollen tube. Currently, little is known about underlying molecular mechanisms that regulate germination and tube growth in maize (Zea mays). Here, a pollen-predominant gene Zm908, with several putative short open reading frames (sORFs), was isolated characterized. The longest ORF Zm908 encodes small protein 97 amino acids. This designated as Zm908p11 distributed throughout Western blot...
Vesicle-cloaked virus clusters, also known as viral vesicles, exhibit higher infectivity than free viruses and demonstrate persistence in the environment well resilience against disinfection. These emerging pathogens represent significant, yet often underestimated, health risks. Our study investigated peroxide disinfection of murine norovirus a surrogate for human elucidated mechanisms. Peracetic acid, neutral peroxide, rapidly inactivated vesicles. In contrast, negatively charged peroxides,...
Abstract Recent advances in high-resolution mass spectrometry have revolutionized metabolomics, enabling the profiling of hundreds thousands metabolic features a single experiment, with widespread applications across health sciences. To streamline analysis metabolomics data, we developed Rodin, Python-based application offering fast, efficient processing large datasets via web interface or programming library. Rodin integrates multiple stages analysis, including feature preprocessing,...
Flatbands in the periodic electronic or photonic structures attract intensive attention due to their infinite effective mass, which leads plenty of physical phenomena, for example, localization electrons photons. However, direct observation bosonic condensate triangle lattice with tunable flatband at room temperature is not realized yet. In this work, we fabricated a microcavity potential and perovskite CsPbBr3 as gain material temperature. microcavity, polariton bands coupling among are...