A5100456060- Ovarian function and disorders
- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Reproductive Health and Technologies
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Gynecological conditions and treatments
- Luminescence and Fluorescent Materials
- Pregnancy and preeclampsia studies
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Birth, Development, and Health
- MicroRNA in disease regulation
- Molecular Sensors and Ion Detection
- Uterine Myomas and Treatments
- Metabolism and Genetic Disorders
- Sulfur Compounds in Biology
- Drug Transport and Resistance Mechanisms
- Sperm and Testicular Function
Women's Hospital, School of Medicine, Zhejiang University
2015-2025
Shandong First Medical University
2023-2025
Peking University
2024-2025
Second Affiliated Hospital of Zhengzhou University
2015-2025
Zunyi Medical University
2013-2025
Kunming Municipal Hospital of Traditional Chinese Medicine
2025
Huazhong University of Science and Technology
2005-2025
Capital Medical University
2023-2025
China Rehabilitation Research Center
2023-2025
Southern University of Science and Technology
2025
Gestational diabetes mellitus (GDM) has been shown to be associated with high risk of in offspring. However, the mechanisms involved and possibilities transgenerational transmission are still unclear. We intercrossed male female adult control first-generation offspring GDM (F1-GDM) mice obtain second-generation (F2) four groups: C♂-C♀, C♂-GDM♀, GDM♂-C♀, GDM♂-GDM♀. found that birth weight significantly increased F2 through paternal line impaired glucose tolerance (IGT). Regardless from F1-GDM...
In vivo fluorescence imaging in the second near-infrared window (NIR-II) has been considered as a promising technique for visualizing mammals. However, definition of NIR-II region and mechanism accounting excellent performance still need to be perfected. Herein, we simulate photon propagation NIR (to 2340 nm), confirm positive contribution moderate light absorption by water intravital perfect 900-1880 nm, where 1400-1500 1700-1880 nm are defined NIR-IIx NIR-IIc regions, respectively....
Significance All cellular life forms use a ring-shaped hexameric helicase during DNA replication. CMG (Cdc45, Mcm2–7, GINS) is the eukaryotic replicative helicase. contains Mcm2–7 that harbors motors. known to bind many other proteins, including leading and lagging polymerase primase. Thus, threading of through at replication fork determines orientation associated polymerases fork, an important structural feature with consequences may direct future experimentation. This report uses cryo-EM...
Gold nanoparticle (AuNP) has been widely used in cancer photothermal therapy (PTT) for ablating accessible tumor, while it is insufficient inhibiting tumor metastasis and relapse current stage. Here, we first developed a novel immunological AuNP through intracellular generation exocytosis combinatorial PTT immunotherapy. Melanoma B16F10 cells were employed to generate AuNPs then shed trapped vesicles extracellular environment with retained antigens (AuNP@B16F10). By further introducing the...
Abstract Individual cells are basic units of life. Despite extensive efforts to characterize the cellular heterogeneity different organisms, cross-species comparisons landscape dynamics have not been achieved. Here, we applied single-cell RNA sequencing (scRNA-seq) map organism-level cell landscapes at multiple life stages for mice, zebrafish and Drosophila. By integrating comprehensive dataset > 2.6 million single cells, constructed a identified signatures common pathways that...
Abstract Primary ovarian insufficiency (POI) is a clinical syndrome of dysfunction characterized by premature exhaustion primordial follicles. POI causes infertility, severe daily life disturbances and long-term health risks. However, the underlying mechanism remains largely unknown. We previously identified Basonuclin 1 ( BNC1 ) mutation from large Chinese pedigree found that mice with targeted Bnc1 exhibit symptoms POI. In this study, we plays key roles in reserve maintaining lipid...
The limited signal of long-wavelength near-infrared-II (NIR-II, 900-1880 nm) fluorophores and the strong background caused by diffused photons make high-contrast fluorescence imaging in vivo with deep tissue disturbed still challenging. Here, we develop NIR-II fluorescent small molecules aggregation-induced emission properties, high brightness, maximal beyond 1200 nm enhancing electron-donating ability reducing donor-acceptor (D-A) distance, to complement scarce bright emissive organic dyes....
Abstract This study was carried out to explore associations between assisted reproductive technology (ART) and maternal neonatal outcomes compared with similar following spontaneously conceived births. We conducted a retrospective cohort of pregnancies by ART (N = 2641) during 2006–2014 naturally 5282) after matching for age birth year. Pregnancy complications, perinatal complications enrolled subjects were investigated analysed multivariate logistic regression. found that in vitro...
Abstract Background Previously, we reported that polyploid giant cancer cells (PGCCs) induced by cobalt chloride (CoCl 2 ) could have generated daughter with strong invasiveness and migration capabilities via asymmetric divisions. This study compared the expression of epithelial-mesenchymal transition (EMT)-related proteins, including E-cadherin, N-cadherin, vimentin, between PGCCs their cells, control breast cell lines MCF-7 MDA-MB-231. The clinicopathological significance EMT-related...
Summary Increased fat mass and redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens oestrogens have been observed, the exact mechanism accumulation during remains obscure. In this study, receptor follicle‐stimulating hormone ( FSH ), a gonadotropin that increases sharply persistently with both males females, is functionally expressed human mouse tissues adipocytes. Follicle‐stimulating was found to promote lipid...
<h3>Background and aims</h3> Human telomerase reverse transcriptase (hTERT) plays an important role in cancer invasion, but the relevant mechanism is not well known. This study aims to investigate of hTERT gastric metastasis. <h3>Design</h3> Proteomics analysis, qPCR western blotting were used screen for hTERT-regulated candidate molecules invasion. Chromatin immunoprecipitation (ChIP) was performed identify binding sites at regulatory region integrin β1 (<i>ITGB1</i>) gene. ChIP assays...
Context: There are increasing concerns that a disrupted endocrine environment may disturb the growth of fetus. Assisted reproductive technology (ART) situates gamete/embryo in supraphysiological estradiol (E2) and, thus, provides an ideal model to investigate this problem. Objective: Our objective was whether maternal high-E2 first trimester increases risks low birth weight (LBW) and small-for-gestational-age (SGA) birth. Methods: In total, 8869 singletons born after fresh embryo transfer...
Context:The elevated low-density-lipoprotein cholesterol (LDL-C) in menopausal women is associated with higher risks of cardiovascular diseases.
As a promising 2D nanocarrier, the biggest challenge of bare black phosphorus nanosheets (BP NSs) lies in inherent instability, while it can be improved by surface modification strategies to great extent. Considering existing infirm BP NSs strategies, A mussels-inspired strong adhesive biomimetic peptide with azide groups for increase stability is synthesized. The on quickly and precisely bind targeting ligand through click chemistry, solving problem nonspecificity secondary other...
Abstract Background Thin endometrium is a primary cause of defective endometrial receptivity, resulting in infertility or recurrent miscarriage. Much effort has been devoted toward regenerating thin by stem cell-based therapies. The human placenta-derived mesenchymal cells (HP-MSCs) are emerging alternative sources MSCs with various advantages. To maximize their retention inside the uterus, we loaded HP-MSCs cross-linked hyaluronic acid hydrogel (HA hydrogel) to investigate therapeutic...
Abstract A series of dinuclear Ru II complexes with extremely high TPA cross sections in the range 800–900 nm have been designed. The amphiphilic complex Ru3 containing tert‐butyl groups has balanced performance singlet oxygen generation and photothermal conversion becomes ideal drug candidate series. targets mitochondria without penetrating nucleus, which substantially increases its photodynamic therapy activity reduces dark cytotoxicity. successfully suppresses melanoma tumor growth vitro...