A5010040587- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Optical Imaging and Spectroscopy Techniques
- Luminescence and Fluorescent Materials
- Advanced Fluorescence Microscopy Techniques
- Civil and Geotechnical Engineering Research
- Infrared Target Detection Methodologies
- Advanced biosensing and bioanalysis techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ovarian function and disorders
- Geotechnical Engineering and Underground Structures
- Analytical Chemistry and Sensors
- Birth, Development, and Health
- Advanced Semiconductor Detectors and Materials
- Non-Invasive Vital Sign Monitoring
- Cancer Research and Treatments
- Landslides and related hazards
- Effects and risks of endocrine disrupting chemicals
- Reproductive Health and Technologies
- Heavy Metal Exposure and Toxicity
- Natural Language Processing Techniques
- Fire effects on concrete materials
- Photodynamic Therapy Research Studies
- Anatomy and Medical Technology
- Optical Coherence Tomography Applications
Zhejiang University
2021-2025
Peking University
2024-2025
National Health and Family Planning Commission
2024-2025
Shanghai Institute of Technical Physics
2024
Tongji University
2018-2024
Shanghai University
2024
State Key Laboratory of Modern Optical Instruments
2021-2023
Central South University
2018
In vivo fluorescence imaging in the second near-infrared window (NIR-II) has been considered as a promising technique for visualizing mammals. However, definition of NIR-II region and mechanism accounting excellent performance still need to be perfected. Herein, we simulate photon propagation NIR (to 2340 nm), confirm positive contribution moderate light absorption by water intravital perfect 900-1880 nm, where 1400-1500 1700-1880 nm are defined NIR-IIx NIR-IIc regions, respectively....
The limited signal of long-wavelength near-infrared-II (NIR-II, 900-1880 nm) fluorophores and the strong background caused by diffused photons make high-contrast fluorescence imaging in vivo with deep tissue disturbed still challenging. Here, we develop NIR-II fluorescent small molecules aggregation-induced emission properties, high brightness, maximal beyond 1200 nm enhancing electron-donating ability reducing donor-acceptor (D-A) distance, to complement scarce bright emissive organic dyes....
Multichannel imaging in the second near-infrared (NIR-II) window offers vital and comprehensive information for complex surgical environments, yet a simple, high-quality, video-rate multichannel method with low safety risk remains to be proposed. Centered at superior NIR-IIx of 1400–1500 nm, triple-channel coordinated 1000–1100 1700–1880 nm (NIR-IIc) achieves exceptional clarity an impressive signal-to-crosstalk ratio as high 22.10. To further simplify light source lower risk, we develop...
Abstract High spatial resolution, low background, and deep tissue penetration have made near-infrared II (NIR-II) fluorescence imaging one of the most critical tools for in vivo observation measurement. However, relatively short retention time potential toxicity synthetic NIR-II fluorophores limit their long-term application. Here, we report use infrared fluorescent proteins (iRFPs) as vitro probes permitting prolonged continuous (up to 15 months). As a representative example, iRFP713 is...
Abstract The near-infrared-IIx (NIR-IIx, 1,400-1,500 nm) sub-window theoretically surpasses the conventional near-infrared-II (NIR-II) region in optical imaging fidelity but requires luminophores with high brightness and stability. Herein, we present a germanium-engineered xanthene fluorophore (EGe5) featuring extended π-conjugation planarized pentagonal core, as unequivocally resolved by single-crystal X-ray analysis. vertically aligned methyl groups sterically hinder molecular vibration,...
Abstract The near-infrared-IIx (NIR-IIx, 1,400-1,500 nm) sub-window theoretically surpasses the conventional near-infrared-II (NIR-II) region in optical imaging fidelity but requires luminophores with high brightness and stability. Herein, we present a germanium-engineered xanthene fluorophore (EGe5) featuring extended π-conjugation planarized pentagonal core, as unequivocally resolved by single-crystal X-ray analysis. vertically aligned methyl groups sterically hinder molecular vibration,...
Abstract Optical imaging through highly turbid water (50 NTU) presents significant challenges due to strong photon scattering effect that impedes effective detection of light signal. Using Monte Carlo simulation, it is found moderate absorption can improve image quality, while unequivocally detrimental. To achieve clear in water, the wavelength illumination has been red‐shifted from traditionally utilized blue‐green near‐infrared, which and low scattering. Experimental results demonstrate...
In-context learning (ICL) advances Large Language Models (LLMs) exhibiting emergent ability on downstream tasks without updating billions of parameters. However, in the area multimodal (MLLMs), two problems hinder application ICL: (1) Most primary MLLMs are only trained single-image datasets, making them unable to read extra demonstrations. (2) With demonstrations increasing, thousands visual tokens highly challenge hardware and degrade ICL performance. During preliminary explorations, we...
Abstract Near‐infrared II (NIR‐II, 900–1880 nm) fluorescence confocal microscopy enables in vivo imaging with high spatial resolution at large depth. Nonetheless, three dimensional (3D) requires capturing substantial pixels and prolonged laser scanning, leading to phototoxicity, exogenous probe metabolic decay, loss of information on dynamic anatomical structures. Strategies diminish duration can be considered by decreasing the actual pixel dwell time without deterioration quality. In this...
The second near-infrared (NIR-II) window is widely acknowledged for its excellent potential in vivo fluorescence imaging. Currently, NIR-II imaging predominantly operates within the 900-1880 nm spectral range, while region beyond 1880 has been disregarded due to large light absorption of water. Based on a refined understanding effect imaging, we propose an approach that utilizes previously neglected surrounding water peak at ~1930 Both simulations and experiments confirm contributes...
Permeabilities of various trace elements (TEs) through the blood–follicle barrier (BFB) play an important role in oocyte development. However, it has not been comprehensively described as well its involved biological pathways. Our study aimed to construct a distribution model concerned TEs and explore their related We finally included total 168 women from cohort vitro fertilization-embryo transfer conducted two reproductive centers Beijing City Shandong Province, China. The concentrations 35...
Abstract The near‐infrared (NIR) tissue window is widely recognized for its exceptional potential in fluorescence bioimaging. Through theoretical simulations utilizing the Monte Carlo (MC) method, coupled with imaging through phantoms, Peak Signal‐to‐Noise Ratio (PSNR) scattering media within spectral range of 900–2500 nm investigated. findings confirm that under specific conditions, light absorption water can enhance quality imaging, although depth must be judiciously trade‐off....
The adverse effect of ambient PM2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort 141,040 cycles to evaluate the VEP using in vitro fertilization and embryo transfer platform high-resolution data China. first investigated association between 1 week before after date VEP. average concentrations 2 weeks were approximately 47 μg/m3. pooled results revealed...
Abstract Achieving high‐resolution and large‐depth microscopic imaging in vivo under conditions characterized by high‐scattering dense‐labeling, as commonly encountered the liver, poses a formidable challenge. Here, through optimization of multi‐photon fluorescence excitation window, tailored to unique optical properties intravital hepatocytes hepatic blood vessels with high spatial resolution was attained. It's worth noting that degradation caused tissue scattering light mitigated...
In this paper, a novelty bandgap gradient multilayer heterojunction (BGMH) HgCdTe long-wavelength infrared detectors (LWIR) to provide low dark current is designed and prototyped. The fabricated photodetector comprised of wide-bandgap p-type cap layer intrinsic region optimize the tunneling surface current, also with responsed narrow n-type bottom layer. BGMH LWIR detector, 100% cutoff wavelength 14 μm, realizes density 5.7×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Fluorescence imaging in the second near-infrared window (NIR-II, 900–1880[Formula: see text]nm) with less scattering background biological tissues has been combined confocal microscopic system for achieving deep vivo high spatial resolution. However, traditional NIR-II fluorescence microscope separate excitation focus and detection pinhole makes it possess low efficiency, as well difficultly to adjust. Two types of upgraded microscopes, sharing same by emission focus, leading higher are...
Optical imaging in the second near-infrared (NIR-II; 900–1880 nm) window is currently a popular research topic field of biomedical imaging. This study aimed to explore application value NIR-II fluorescence foot and ankle surgeries. A lab-established surgical navigation system was developed used navigate surgeries which enabled obtaining more high-spatial-frequency information higher signal-to-background ratio (SBR) images compared NIR-I images; our result demonstrates that could provide...
Machine learning (ML) models can be used to improve therapeutic schedule and predict outcomes for the women undergoing in vitro fertilization embryo transfer (IVF-ET). However, there is still lacking of a high-quality platform facilitate user-interactive modeling key predictors are under discussion. We aimed build an analytical framework reproductive IVF-ET ascertain crucial clinical factors. Our study adopted various features 53,156 fresh cycles 45,559 from eight typical centers China...
More and more end-to-end text spotting methods based on Transformer architecture have demonstrated superior performance. These utilize a bipartite graph matching algorithm to perform one-to-one optimal between predicted objects actual objects. However, the instability of can lead inconsistent optimization targets, thereby affecting training performance model. Existing literature applies denoising solve problem in object detection tasks. Unfortunately, this method cannot be directly applied...