A5100384400- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Perovskite Materials and Applications
- Photodynamic Therapy Research Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Molecular Sensors and Ion Detection
- Rabies epidemiology and control
- Ferroelectric and Piezoelectric Materials
- Dielectric properties of ceramics
- Microwave Dielectric Ceramics Synthesis
- Luminescence Properties of Advanced Materials
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Processes in Materials Science
- Enzyme Structure and Function
- Mosquito-borne diseases and control
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- Photoacoustic and Ultrasonic Imaging
- Click Chemistry and Applications
- Viral Infections and Outbreaks Research
- Lanthanide and Transition Metal Complexes
- Nanocluster Synthesis and Applications
- Quantum Dots Synthesis And Properties
University of Science and Technology of China
2025
Jilin University
2004-2024
First Affiliated Hospital of Henan University
2024
Zhongshan Hospital
2024
Fudan University
2024
Taiyuan University of Technology
2023-2024
Nanjing University of Posts and Telecommunications
2018-2023
Lanzhou University
2023
Sichuan University of Science and Engineering
2023
HKUST Shenzhen Research Institute
2018-2022
Abstract Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose molecular design philosophy explore pure fluorophores by manipulation effects twisted intramolecular charge transfer and aggregation-induced at...
Abstract Developing high-efficient afterglow from metal-free organic molecules remains a formidable challenge due to the intrinsically spin-forbidden phosphorescence emission nature of afterglow, and only few examples exhibit efficiency over 10%. Here, we demonstrate that can be enhanced dramatically by thermally activated processes release excitons on stabilized triplet state (T 1 * ) lowest singlet excited (S for spin-allowed emission. Designed in twisted donor–acceptor architecture with...
Abstract The shortage of high quantum yield (QY) organic fluorophores in the second near‐infrared window (NIR‐II) has become a bottleneck bioimaging field. Now, simple strategy is proposed to address this: constitutional isomerization on basis molecular design philosophy aggregation‐induced emission. With combination backbone distortion and rotor twisting, resultant NIR‐II fluorophore 2TT‐ o C6B displays an emission peak at 1030 nm QY 11% nanoparticles, one highest reported so far. Control...
Semiconducting polymer nanoparticles (SPNs) emitting in the second near-infrared window (NIR-II, 1000–1700 nm) are promising materials for deep-tissue optical imaging mammals, but brightness is far from satisfactory. Herein, we developed a molecular design strategy to boost of NIR-II SPNs: structure planarization and twisting. By integration strong absorption coefficient inherited planar π-conjugated units high solid-state quantum yield (ΦPL) twisted motifs into one polymer, rise was...
Fluorescence imaging in the second near-infrared window (NIR-II) is a new technique that permits visualization of deep anatomical features with unprecedented spatial resolution. Although attractive, effectively suppressing interference signal background still an enormous challenge for obtaining target-specific NIR-II complex and dynamic physiological environment. Herein, dual-pathological-parameter cooperatively activatable fluorescence nanoprobes (HISSNPs) are developed whereby hyaluronic...
Phototheranostics is a potential area for precision medicine, which has received increasing attention antibacterial applications. Integrating all phototheranostic modalities in single molecule and achieving precise spatial colocalization challenging task because of the complexity energy dissipation molecular design. Here, type quaternary amine functionalized aggregation-induced emission (AIE), AIEgen, was synthesized used to produce singlet oxygen (1O2) heat, were eradicate bacteria. With...
The limited signal of long-wavelength near-infrared-II (NIR-II, 900-1880 nm) fluorophores and the strong background caused by diffused photons make high-contrast fluorescence imaging in vivo with deep tissue disturbed still challenging. Here, we develop NIR-II fluorescent small molecules aggregation-induced emission properties, high brightness, maximal beyond 1200 nm enhancing electron-donating ability reducing donor-acceptor (D-A) distance, to complement scarce bright emissive organic dyes....
Although photothermal therapy (PTT) has thrived as a promising treatment for drug-resistant bacterial infections by avoiding the abuse of antibiotics, remaining challenges that limit efficiency are poor targeting properties infected lesions and low penetration to cell membrane Gram-negative bacteria. Herein, we developed biomimetic neutrophil-like aggregation-induced emission (AIE) nanorobot (CM@AIE NPs) precise inflammatory site homing efficient PTT effects. Due their surface-loaded...
To meet the requirements of biomedical applications in antibacterial realm, it is great importance to explore nano-antibiotics for wound disinfection that can prevent development drug resistance and possess outstanding biocompatibility. Therefore, we attempted synthesize an atomically dispersed ion (Fe) on phenolic carbon quantum dots (CQDs) combined with organic photothermal agent (PTA) (Fe@SAC CQDs/PTA) via a hydrothermal/ultrasound method. Fe@SAC CQDs adequately exerted peroxidase-like...
Photodynamic therapy (PDT) is a promising noninvasive therapeutic technique and has attracted increasing interests in preclinical trials. However, the translation from laboratory to clinic often encounters problem of undesired dark cytotoxicity photosensitizers (PSs). Now, this challenge can be addressed by cascaded substitution activated phototheranostics using host–guest strategy. Through electrostatical complexation pyridinium-functionalized tetraphenylethylene, namely, TPE-PHO,...
Our exploiting versatile multimodal theranostic agent aims to integrate the complementary superiorities of photoacoustic imaging (PAI), second near-infrared (NIR-II, 1000-1700) fluorescence and T1-weighted magnetic resonance (MRI) with an ultimate objective perfecting cancer diagnosis, thus improving therapy efficacy.Herein, we engineered prepared a water-soluble gadolinium-chelated conjugated polymer-based nanomedicine (PFTQ-PEG-Gd NPs) for in vivo tri-mode PA/MR/NIR-II imaging-guided tumor...
The singlet oxygen (
The brightness of organic fluorescence materials determines their resolution and sensitivity in display detection. However, strategies to effectively enhance the are still scarce. Conventional planar π-conjugated molecules excellent photophysical properties as isolated species but suffer from aggregation-caused quenching effect when aggregated owing cofacial π–π interactions. In contrast, twisted show high photoluminescence quantum yield (ΦPL) aggregate while at cost absorption due breakage...
All matter is in motion, and such behavior has been well studied the gas liquid states. However, study of solid-state molecular motion still its infancy, mainly, because absence valid characterization methods. Aggregation-induced emission (AIE) a cutting-edge fluorescence technology related to aggregate-state luminescence. Thus, it holds great potential address this issue. AIE luminogens (AIEgens) are often propeller-like shape are, therefore, born with mobility. The AIEgens determined by...
Polyelectrolytes play an important role in both natural biological systems and human society, their synthesis, functional exploration, profound application are thus essential for biomimicry creating new materials. In this study, we developed efficient synthetic methodology situ generation of azonia-containing polyelectrolytes a one-pot manner by using readily accessible nonionic reactant the presence commercially available cheap ionic species. The resulting emissive solid state can form...
Molecules have limited mobility in the solid state because of strong intermolecular interactions, and therefore, applications based on solid-state molecular motions are seldom explored. Herein, by manipulating intramolecular motion tetraphenylethylene (TPE) a crystallizing polymer matrix, controlled fluorescent patterns with information storage encoding functionality developed. The TPE can not only affect fluorescence intensity but also determine photocyclization activity, which be tuned...
Abstract Although organic materials with near infrared (NIR)‐II fluorescence and a photothermal effect have been widely investigated for the accurate diagnosis treatment of tumors, optimizing output signals both remain challenging. Here, strategy by “enlarging absorption reservoir” to address this issue, since an increase in photon can naturally enhance signals, is proposed. As proof‐of‐concept, large π‐conjugated diketopyrrolopyrrole (DPP) unit selected fabricate strong light‐absorbing...
Abstract Chronic wounds caused by bacterial infections are a major challenge in medical fields. The hypoxia condition extremely induces reactive oxygen species (ROS) generation and upregulates the expression of hypoxia‐inducible factor, both which can increase pro‐inflammatory M1 subtype macrophages production while reducing anti‐inflammatory M2 macrophages. Besides, bacteria‐formed biofilms hinder penetration therapeutic agents. Encouraged natural motors automatically executing tasks,...
Whether and how nanoclusters possessing a rich diversity of possible geometric configurations can transform from one structural type to another are critical issues in cluster science. Here we demonstrate an icosahedral-to-cuboctahedral transformation Au driven by changing the chemical environment. For icosahedral Au(13) clusters protected mixture dodecanethiol triphenylphosphine ligands, solvent exchange ethanol hexane leads quick selective desorption thiolate layers surface. The surviving...
Strongly red luminescent and water-soluble probes are very important for studying biological events processes. Fluorescent nanoparticles (NPs) built from the aggregation-induced emission luminogen (AIEgen) amphipathic polymeric matrixes have been considered as promising candidates bioimaging. However, AIE NPs with long-wavelength absorption suitable in vivo application still scarce. In this work, three AIE-active red-emissive BODIPY derivatives were rationally designed synthesized. Then...
Iatrogenic ureteral injury is a dreaded complication of abdominal and pelvic surgeries, thus, intraoperative identification ureters paramount importance but lacks efficient methods probes. Herein, we used near-infrared II (NIR-II, 1000–1700 nm) fluorescence imaging with advantages higher spatial resolution, deeper tissue penetration, lower light scattering, less autofluorescence to identify by aggregation-induced emission luminogen dots (AIE dots). The injuries common diseases can be...
An activatable organic semiconducting nanoprobe that specifically turns on its second near-infrared window fluorescence upon being exposed to nitric oxide stimuli was developed for in vivo, situ, real-time and high-spatial-resolution mapping of drug-induced hepatotoxicity.