A5063552401- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Assistive Technology in Communication and Mobility
- Molecular Sensors and Ion Detection
- Supramolecular Self-Assembly in Materials
- Gaze Tracking and Assistive Technology
- Photoacoustic and Ultrasonic Imaging
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Stroke Rehabilitation and Recovery
- Extracellular vesicles in disease
- Dendrimers and Hyperbranched Polymers
- Cerebral Palsy and Movement Disorders
- Context-Aware Activity Recognition Systems
- Click Chemistry and Applications
- Gastric Cancer Management and Outcomes
- Polydiacetylene-based materials and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Organic Light-Emitting Diodes Research
- Perovskite Materials and Applications
- Immunotherapy and Immune Responses
Nankai University
2016-2025
State Key Laboratory of Medicinal Chemical Biology
2016-2025
Xinxiang Medical University
2024-2025
VA Pittsburgh Healthcare System
2013-2024
University of Pittsburgh
2015-2024
Tianjin Stomatological Hospital
2019-2024
Tianjin University
2020-2024
State Grid Corporation of China (China)
2024
South China University of Technology
2018-2024
Ministry of Education
2015-2024
Abstract Light emission of 2‐(2,6‐bis(( E )‐4‐(diphenylamino)styryl)‐4 H ‐pyran‐4‐ylidene)malononitrile (TPA‐DCM) is weakened by aggregate formation. Attaching tetraphenylethene (TPE) units as terminals to TPA‐DCM dramatically changes its behavior: the resulting fluorogen, )‐4‐(phenyl(4′‐(1,2,2‐triphenylvinyl)‐[1,1′‐biphenyl]‐4‐yl)amino)styryl)‐4 (TPE‐TPA‐DCM), more emissive in state, showing novel phenomenon aggregation‐induced (AIE). Formulation TPE‐TPA‐DCM using bovine serum albumin (BSA)...
Planar donor and acceptor (D–A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order restrict intramolecular motions aggregates (nanoparticles). However, other channels of extra nonradiative decay may blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion aggregates. Molecular rotors bulky alkyl chains grafted central D–A core lower intermolecular...
Optical theranostic nanoagents that seamlessly and synergistically integrate light-generated signals with photothermal or photodynamic therapy can provide opportunities for cost-effective precision medicine, while the potential clinical translation requires them to have good biocompatibility high imaging/therapy performance. We herein report an intraparticle molecular orbital engineering approach simultaneously enhance photoacoustic brightness efficacy of semiconducting polymer nanoparticles...
Immunogenic cell death (ICD) provides momentous theoretical principle for modern cancer immunotherapy. However, the currently available ICD inducers are still very limited and photosensitizer-based ones can hardly induce sufficient to achieve satisfactory immunotherapy by themselves. Herein, an organic photosensitizer (named TPE-DPA-TCyP) with a twisted molecular structure, strong aggregation-induced emission activity, specific ability is reported effectively inducing focused mitochondrial...
Afterglow imaging through the collection of persistent luminescence after stopping light excitation holds enormous promise for advanced biomedical uses. However, efficient near-infrared (NIR)-emitting afterglow luminescent materials and probes (particularly organic polymeric ones) are still very limited, their in-depth applications such as precise image-guided cancer surgery rarely reported. Here, we design synthesize a NIR nanoparticle with aggregation-induced emission (AIE) characteristics...
Photodynamic therapy (PDT), which relies on photosensitizers (PS) and light to generate reactive oxygen species kill cancer cells or bacteria, has attracted much attention in recent years. PSs with both bright emission efficient singlet generation have also been used for image-guided PDT. However, simultaneously achieving effective 1 O2 generation, long wavelength absorption, stable near-infrared (NIR) low dark toxicity a single PS remains challenging. In addition, it is well known that when...
The exciting applications of molecular motion are still limited and in urgent pursuit, although some fascinating concepts such as motors machines have been proposed for years. Utilizing a nanoplatform practical application has scarcely explored due to unconquered challenges how achieve effective the aggregate state within nanoparticles. Here, we introduce class near infrared-absorbing organic molecules with intramolecular motion-induced photothermy inside nanoparticles, which enables most...
Abstract The study of purely organic room‐temperature phosphorescence (RTP) has drawn increasing attention because its considerable theoretical research and practical application value. Currently, RTP materials with both high efficiency (Φ P > 20%) a long lifetime (τ 10 s) in air are still scarce due to the lack related design guidance. Here, new strategy increase performance by integrating host guest one doping system form triplet exciplex, is reported. With these materials,...
Long-term noninvasive cell tracing by fluorescent probes is of great importance to life science and biomedical engineering. For example, understanding genesis, development, invasion metastasis cancerous cells monitoring tissue regeneration after stem transplantation require continual the biological processes cytocompatible over a long period time. In this work, we successfully developed organic far-red/near-infrared dots with aggregation-induced emission (AIE dots) demonstrated their...
Pure organic persistent room-temperature phosphorescence (p-RTP) under ambient conditions is attractive but challenging due to the slow intersystem crossing process and susceptibility of triplet excitons. Fabrication pure RTP luminogens with simultaneously high efficiency ultralong lifetime still remains a daunting job, owing their conflicting requirements for T1 nature (n,π*) (π,π*) characteristics, respectively. Herein, group amide-based derivatives efficient p-RTP developed through...
Abstract Organic near-infrared room temperature phosphorescence materials have unparalleled advantages in bioimaging due to their excellent penetrability. However, limited by the energy gap law, (>650 nm) are very rare, moreover, lifetimes of these short. In this work, we obtained organic with long wavelengths (600/657–681/732 and (102–324 ms) for first time through guest-host doped strategy. The guest molecule has sufficient conjugation reduce lowest triplet level host assists exciton...
Bacterial infection is one of the most serious physiological conditions threatening human health. There an increasing demand for more effective bacterial diagnosis and treatment through noninvasive theranostic approaches. Herein, a new strategy reported to achieve in vivo metabolic labeling bacteria use MIL-100 (Fe) nanoparticles (NPs) as nanocarrier precise delivery 3-azido-d-alanine (d-AzAla). After intravenous injection, NPs can accumulate preferentially degrade rapidly within high H2 O2...
Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, low in vivo toxicity. Real-time intravital blood vascular imaging various tissues substantiates that the AIE effective probes for vasculature deep high-contrast manner. As service our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be...
The first mitochondrion‐anchoring photosensitizer that specifically generates singlet oxygen ( 1 O 2 ) in mitochondria under white light irradiation can serve as a highly effective radiosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation. An aggregation‐induced emission luminogen (AIEgen), namely DPA‐SCP, rationally designed with α‐cyanostilbene simple building block reveal AIE, diphenylamino (DPA) group strong electron donating benefit red and efficient...
An activatable photoacoustic nanoprobe based on a semiconducting oligomer with amplified brightness and pH-sensing capability is developed by taking advantage of nanodoping to simultaneously create both intraparticle photoinduced electron transfer intramolecular protonation within single particle. This organic permits noninvasive real-time ratiometric imaging pH in tumors living mice through systemic administration at relatively low dosage. As service our authors readers, this journal...
Abstract Host–guest complexation between calix[5]arene and aggregation‐induced emission luminogen (AIEgen) can significantly turn off both the energy dissipation pathways of intersystem crossing thermal deactivation, enabling absorbed excitation to mostly focus on fluorescence emission. The co‐assembly amphiphiles AIEgens affords highly emissive supramolecular AIE nanodots thanks their interaction severely restricting intramolecular motion AIEgens, which also show negligible generation...
Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially...
Development of optical nanotheranostics for the capability photodynamic therapy (PDT) provides opportunities advanced cancer therapy. However, most nanotheranostic systems fail to regulate their generation levels reactive oxygen species (ROS) according disease microenvironment, which can potentially limit therapeutic selectivity and increase risk damage normal tissues. We herein report development hybrid semiconducting polymer nanoparticles (SPNs) with self-regulated near-infrared (NIR)...
Activatable phototheranostics is highly appealing to meet the demand of precision medicine. However, although it displays efficacy in construction activatable photosensitizers (PSs), direct covalent decoration still shows some inevitable issues, such as complex molecular design, tedious synthesis, possible photoactivity changes, and potential toxicity. Herein, we propose a novel concept biomarker displacement activation (BDA) using host–guest strategy. To exemplify BDA, engineered PS-loaded...