A5041819469- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Digital Imaging for Blood Diseases
- Histone Deacetylase Inhibitors Research
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Neonatal Health and Biochemistry
- Childhood Cancer Survivors' Quality of Life
- Autoimmune and Inflammatory Disorders Research
- Iron Metabolism and Disorders
- Neutropenia and Cancer Infections
- MicroRNA in disease regulation
- Immune cells in cancer
- Hemoglobinopathies and Related Disorders
- Food Quality and Safety Studies
- Acute Lymphoblastic Leukemia research
- RNA Research and Splicing
- Fermentation and Sensory Analysis
- RNA modifications and cancer
- Reproductive biology and impacts on aquatic species
- Lymphadenopathy Diagnosis and Analysis
Second Affiliated Hospital of Chongqing Medical University
2013-2025
Dalian Medical University
2013-2025
Chongqing Medical University
2013-2025
Jimei University
2025
Key Laboratory of Guangdong Province
2023
Guangdong Ocean University
2023
Yunnan Agricultural University
2011
London Health Sciences Centre
2010
Western University
2006
Abstract N6-methyladenosine (m6A) is the most abundant posttranscriptional modification of mRNA in eukaryotes. Recent evidence suggests that dysregulated m6A-associated proteins and m6A modifications play a pivotal role initiation progression diseases such as cancer. Here, we identified IGF2BP3 specifically overexpressed acute myeloid leukemia (AML), subtype associated with poor prognosis high genetic risk. required for maintaining AML cell survival an m6A-dependent manner, knockdown...
Acute myeloid leukemia (AML) is a clonal malignant proliferative blood disorder with poor prognosis. Ferroptosis, novel form of programmed cell death, holds great promise for oncology treatment, and has been demonstrated to interfere the development various diseases. A range genes are involved in regulating ferroptosis can serve as markers it. Nevertheless, prognostic significance these AML remains poorly understood. Transcriptomic clinical data patients were acquired from The Cancer Genome...
•Multidimensional techniques reveal the comprehensive flavor profile of aged vinegar.•Key flavor-active compounds in Yongchun Aged Vinegar were identified.•Aging enhances vinegar freshness and sweetness, boosting consumer acceptability.•Total soluble solids volatile are core quality indicators vinegar.
Hematopoietic stem cells (HSCs) are susceptible to replication stress, which is a major contributor HSC defects in Fanconi anemia (FA). Here, we report that HSCs relax the global chromatin by downregulating expression of architectural protein, DEK, response stress. DEK abnormally accumulated bone marrow (BM) CD34+ from patients with FA and Fancd2-deficient HSCs. haploinsufficiency promotes relaxation, stress relief, function recovery Furthermore, inhibition restores proliferation vitro...
Objective: Acute myeloid leukemia (AML) is a malignant clonal disorder. Despite enormous progress in its diagnosis and treatment, the mortality rate of AML remains high. The aim this study was to identify prognostic biomarkers by using gene expression profile dataset from public database, improve risk-stratification criteria survival for patients with AML. Materials methods: data clinical parameter were acquired Therapeutically Applicable Research Generate Effective Treatment (TARGET)...
Abstract Inherited anemia continues to pose a significant public health concern on global scale, owing its extensive geographical prevalence, substantial patient population, and profound ramifications. Here, we investigated detailed information inherited anemias (including thalassemias, thalassemias trait, sickle cell disease, G6PD deficiency, trait) for the period 1990–2019 from Global Burden of Disease study. Over course three decades, there has been persistent rise in incidence worldwide,...
CD45RB monoclonal antibody (mAb) therapy is capable of prolonging allograft survival. We have previously shown that mAb enriches the CD45RBlo T-cell population in vitro and vivo by preferentially depleting CD45RBhi T cells. The present study assessed importance depletion murine cardiac survival infusion naive subsets. Here we show naturally occurring CD45RBloCD4+ cells express regulatory transcription factor Foxp3 function, whereas CD45RBhiCD4+ low levels effector function. Infusion...
This study was conducted to evaluate the effect of dietary lysozyme supplementation on growth performance and plasma biochemical parameters rainbow trout (Oncorhynchus mykiss). Graded levels [0 (control), 150, 300, 450 600 mg kg−1 diet] were fed fish (initial average weight 7.76 g) for 10 weeks. Dietary regardless inclusion level generally improved growth, feed utilization nutrient retention, but significant differences mainly observed between or group control group. Lysozyme decreased...
Alternative splicing (AS), a crucial post-transcriptional regulatory mechanism in expanding the coding capacities of genomes and increasing diversity proteins, still faces various challenges regulation acute myeloid leukemia (AML) microenvironmental changes.A total 27,833 AS events were detected 8337 genes 178 AML patients, with exon skip being predominant type. Approximately 11% significantly related to prognosis, prediction models based on demonstrated high classification efficiencies....
Abstract Background To assess the prevalence trend and contributing factors of heart failure (HF) impairment with thalassemias at global, regional national levels. Methods Data on HF was collected from Global Burden Disease study. The absolute number disease were systematically for each year, estimated annual percentage changes (EAPC) in calculated by gender, region country to measure temporal trends. Results Thalassemias have caused a significant global burden since 1990, case related has...
Plants are sensitive to external environmental conditions and the mechanisms of stress tolerance in plants complex. As one most significant epigenetic phenomena, DNA methylation plays a crucial role plants' adaptation changes. Recent research has improved our understanding relationship between tolerance. Here, we review mechanism discuss recent reports dynamics under abiotic conditions, including high salt concentration, drought, extreme temperatures. The important functions during response...
Acute myeloid leukemia (AML) is a common hematological malignancy. Gemtuzumab ozogamicin (GO), humanized anti-CD33 antibody conjugated with the potent anti-tumor antibiotic calicheamicin, represents promising targeted therapy for AML. Annexin A5 (ANXA5) proposed marker clinical prognosis of AML to guide treatment choice.In total, 253 patients pediatric were enrolled and divided into two groups: conventional chemotherapy alone in combination GO. Univariate, multivariate, Kaplan-Meier survival...
Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy in pediatrics, and immune-related genes (IRGs) play crucial role its development. Our study aimed to identify prognostic immune biomarkers of pediatric ALL construct a risk assessment model.Pediatric patients' gene expression data were downloaded from Therapeutically Applicable Research Generate Effective Treatments (TARGET) database. We screened differentially expressed IRGs (DEIRGs) between relapse non-relapse...
The aim of the present study was to establish a quantitative method for measurement serum human augmenter liver regeneration (hALR) using competitive inhibition that is applicable in clinic. A monoclonal antibody hALR used as primary and pure protein standard competition with Eu3+‑labeled (Eu3+-hALR) plot curve. Serum samples from 90 patients various diseases due hepatitis B virus (HBV) infection were reaction Eu3+-hALR. regression analysis results performed curve calculate concentration...
Purpose: Acute myeloid leukaemia (AML) is a common haematological disease in adults. The overall survival (OS) remains unsatisfactory. It critical to identify potential prognostic biomarkers and develop nomogram that predicts patients with AML. Patients Methods: We used gene expression dataset clinical data from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) differential analysis, value of IGHD family ( IGHDs ) AML patients. A risk score model was built through Lasso analysis...
In recent years, great progress has been made in haploidentical hematopoietic stem cell transplantation (haplo-HSCT) treatment for hematological malignant diseases because of the advent novel conditioning regimens, optimized graft manipulation, improved graft-versus-host disease (GVHD) prophylaxis, and advances supportive care. Recent studies have shown very favorable outcomes severe aplastic anemia (SAA) patients, with comparable to those patients receiving immune suppressive therapy (IST)...