A5101800137- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Retinal and Macular Surgery
- RNA modifications and cancer
- Retinal Diseases and Treatments
- Hematopoietic Stem Cell Transplantation
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Cancer-related molecular mechanisms research
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Cancer-related gene regulation
- Amoebic Infections and Treatments
- Corneal Surgery and Treatments
- Cytomegalovirus and herpesvirus research
- Ocular Infections and Treatments
- Virus-based gene therapy research
- Ocular Surface and Contact Lens
- Marine Sponges and Natural Products
- Phytochemical compounds biological activities
- Stroke Rehabilitation and Recovery
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
Capital Medical University
2016-2025
Beijing Friendship Hospital
2014-2025
Shanghai Ninth People's Hospital
2025
Shanghai Jiao Tong University
2021-2025
Xinqiao Hospital
2022-2024
Army Medical University
2023-2024
China-Japan Friendship Hospital
2023-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Center for Excellence in Brain Science and Intelligence Technology
2024
University of Chinese Academy of Sciences
2024
Abstract Neutrophil migration into the site of infection is necessary for antibacterial innate defense, whereas impaired neutrophil may result in excessive inflammation and even sepsis. The directed by extracellular signals such as chemokines has been extensively studied, yet intrinsic mechanism determining ability to migrate needs further investigation. N 6 -methyladenosine (m A) RNA modification important immunity inflammation, our preliminary data indicate downregulation m A demethylase...
Ischemic stroke is a cerebrovascular disease with high mortality and disability. Due to similar physiological characteristics, ocular vascular characteristics are important indicators for monitoring diseases. This study aimed develop nomogram prediction model ischemic based on hemodynamic characteristics. Retrospective clinical cohort study. A total of 337 patients were included in this randomly divided into 253 training 102 validation cohorts. The general data collected, the parameters...
Abstract Choroidal neovascularization(CNV) is the most severe complication in Age-related macular degeneration(AMD) and common cause of irreversible blindness elderly developed world. The aim this study was to identify effect transforming growth factor-β(TGF-β) Smad2/3-VEGF/TNF-α signaling on CNV angiopoiesis, explore TGF-β inhibitors development a mouse model. Fundus fluorescein angiography(FFA) used evaluate laser-induced formation. histology lesions stained with hematoxylin-eosin(HE)...
Abstract Emergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF) through its receptor G-CSFR are essential for antibacterial innate defense. However, the epigenetic modifiers crucial intrinsically regulating expression response of neutrophils remain largely unclear. N 6 -methyladenosine (m A) RNA modification related demethylase alkB homolog 5 (ALKBH5) key regulators immunity inflammation, but their roles in production still...
Objective To compare the efficacy and safety of modified versus standard Valsalva maneuver in treatment paroxysmal supraventricular tachycardia (PSVT). Methods The PubMed, Embase, Web Science, CNKI, WanFang Data, VIP electronic databases were searched to identify studies comparing maneuvers PSVT from database inception 1 May 2023. Two reviewers independently screened literature, extracted data, assessed risk bias all included studies. Results Nineteen randomized controlled trials involving...
Quassinoids are a class of highly oxygenated degraded triterpenoids exclusively discovered from plants the Simaroubaceae family. In this study, eight new (1–8) and 15 known quassinoids (9–23) were isolated an extract stems Picrasma quassioides. The structures elucidated by spectroscopic analysis electronic circular dichroism spectra combined with quantum chemical calculations. Compounds 4 5 represent first examples 18-nor-quassinoids P. All isolates screened for their neuroprotective...
Type I interferons (IFN-I) play crucial roles in antiviral immune responses through inducing multiple interferon stimulated genes (ISGs). RNA modifications are emerging as critical post-transcriptional regulators of gene expression programs, which affect diverse biological processes. 2'-O-methylation (Nm) is one the most common types found several kinds RNA. However, function and underlying mechanism Nm modification regulating viral infection innate immunity largely unknown. Here we that...
BackgroundAlthough chimeric antigen receptor-modified T cells (CAR T) cell therapy has been widely reported in improving the outcomes of B-cell acute lymphoblastic leukemia (B-ALL), less research about feasibility and safety donor-derived CAR after allogeneic hematopoietic stem transplantation (allo-HSCT) was reported.MethodsThis phase 1 clinical trial aims to evaluate efficacy anti-CD19 (GC007g) B-ALL patients who relapsed allo-HSCT. This is registered with ClinicalTrials.gov,...
To compare the outcomes of patients with hematological malignancies who received ATG-Fresenius (ATG-F) 20 mg/kg versus those ATG-Genzyme (ATG-G) 10 in an unrelated donor hematopoietic stem cell transplantation (HSCT) procedure, a total 186 underwent their first allogeneic HSCT were retrospectively analyzed. One hundred and seven ATG-F, seventy-nine ATG-G. Multivariate analysis showed that type ATG preparation had no effect on neutrophil engraftment (P = 0.61), cumulative incidence relapse...
Background Ocular ischemic syndrome (OIS) and subsequent neovascular glaucoma (NVG) lead to irreversible visual impairment. This study aimed investigate the association of carotid artery revascularization collateral circulation types via circle Willis (CoW) with NVG prognosis in patients OIS. Methods retrospective cohort included 22 OIS, a median follow-up 12 months. The patterns CoW were classified into five types. revascularization, CoW, morphological characteristics presence outcomes was...
Purpose: To evaluate the short- and long-term effect of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling on visual acuity macular morphology in myopic foveoschisis (MF) patients to identify potential prognostic factors. Methods: We retrospectively analyzed clinical data MF who underwent PPV ILM by same senior fundus surgeon at Beijing Friendship Hospital from January 2016 December 2022. The was strategically centered fovea, extending encompass superotemporal...
Cancer/testis antigen (CTA) family is restricted to germline and tumor cells plays an important role during cancer initiation progression. Five single-cell two bulk RNA-seq datasets are integrated screen genes in the CTAs family, revealing that Placenta specific protein 1 (Plac1) specifically expressed head neck squamous cell carcinoma (HNSCC) cells. Sp1 Transcription (SP1) identified as a regulator of Plac1, which confirmed by cleavage under targets tagmentation (CUT&Tag)-seq. With vitro...
Abstract With the deepening of epigenetic research, studies have shown that N 6 -methyladenosine (m A) is closely related to development rheumatoid arthritis (RA), but mechanism still unclear. In study, we collected synovial tissues from normal controls and patients with osteoarthritis (OA) or RA. The levels m A inflammation were analyzed by immunofluorescence staining western blotting. roles IGF2BP3 in cell proliferation inflammatory activation explored using transfection RNA...
Associations between hyperhomocysteinemia and prognosis of stroke were seldom explored always indefinite. We therefore performed a study to elucidate the relationship homocysteine levels prognosis. Between 2008 2013, baseline data blood samples acute ischemic patients collected from Henan Province Stroke Registry. Using prospective cohort, scheduled follow-up, multivariable logistic regression analysis, associations among level neurological impairment outcomes, recurrence, all-cause death...
Hypertensive retinopathy (HRP) is a clinical feature and systemic manifestation of hypertension. There have been few reports on the risk factors for hypertensive in China. The aim present study was to describe associated with HRP population-based sample Chinese patients hypertension Beijing. data 228 retrospectively studied, including 112 group 116 without NO-HRP group. Basic plasma indicators two groups were compared. Logistic regression models used assess HRP. Duration hypertension,...
Background : This study aims to evaluate ocular changes in patients with ischemic stroke using multimodal imaging and explore the predictive value of abnormalities for stroke. Methods A total 203 (ischemic group, 62; control 141) were enrolled this study. Basic data from patients, including age; gender; height; weight; history hypertension, hyperlipidemia, diabetes, alcohol use, coronary heart disease; smoking status, collected. Consequently, Doppler color ultrasound, fundus photography,...