A5100779086- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Neurological diseases and metabolism
- Genetics and Neurodevelopmental Disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- RNA regulation and disease
- Urinary Bladder and Prostate Research
- Retinal Imaging and Analysis
- Folate and B Vitamins Research
- Hereditary Neurological Disorders
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- IL-33, ST2, and ILC Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Spinal Cord Injury Research
- Genetic Neurodegenerative Diseases
- Cerebral Venous Sinus Thrombosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- S100 Proteins and Annexins
- Noise Effects and Management
First Affiliated Hospital of Zhengzhou University
2016-2025
Nanjing Medical University
2025
Jiangsu Province Hospital
2025
Xijing Hospital
2025
Chinese PLA General Hospital
2013-2020
Northwestern Polytechnical University
2019
Army Medical University
2016
Southwest Hospital
2016
National Institute of Neurological Disorders and Stroke
2015
Zhengzhou University
2015
The benefits of intravenous thrombolysis in patients with acute minor stroke remain controversial. For the aim providing a better therapeutic strategy, high-quality trials are required to validate efficacy thrombolytic medicine other than recombinant tissue plasminogen and tenecteplase. In trial, we evaluate safety urokinase (UK) stroke. This multicenter, open-label, blinded-endpoint, randomized controlled clinical trial enrolled within 6 h symptom onset, NIHSS score ≤ 5. was conducted at 25...
Background: The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP) is considered a novel score to reflect systemic inflammation nutritional status. This study aimed investigate the association between HALP poor outcome in patients with acute ischemic stroke (AIS). Methods: Consecutive AIS within 24 h after onset were prospectively enrolled. Poor was combination new event (ischemic hemorrhagic) all-cause death 90 days 1 year. analyzed using Cox proportional hazards....
Existing techniques have many limitations in the diagnosis and classification of ischemic stroke (IS). Considering this, we used metabolomics to screen for potential biomarkers IS its subtypes explore underlying related pathophysiological mechanisms. Serum samples from 99 patients with acute (AIS) [the AIS included 49 large artery atherosclerosis (LAA) 50 small occlusion (SAO)] matched healthy controls (HCs) were analyzed by non-targeted based on liquid chromatography–mass spectrometry. A...
Aim: The atherogenic index of plasma (AIP) was significantly related to adverse outcomes in patients with cardiovascular disease. Our aim investigate the association between AIP and acute ischemic stroke. Methods: Patients stroke (AIS) admitted 2015 2018 were prospectively enrolled this study. Functional evaluated by modified Rankin Scale (mRS). Poor defined as mRS 3-6. relationship risk analyzed multivariate logistic regression models. Results: A total 1,463 AIS within 24 h symptom onset...
Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in absence of tumor metastasis. Patients with this produce multiple antibodies, each targeting a different antigen causing symptoms signs. The CV2/collapsin response mediator protein 5 (CRMP5) antibody is major type. It damages system, which often manifests as limbic encephalitis, chorea, ocular manifestation, cerebellar ataxia,...
Objectives Mutations in RAB39B have been reported as a potential cause of X-linked Parkinson's disease (PD), rare form familial PD. We conducted genetic analysis on to evaluate whether mutations are related PD the Chinese population. Methods In this study, 2 patients from an juvenile parkinsonism pedigree were clinically characterized and underwent whole-exome sequencing. A comprehensive screening for 505 sporadic with 510 healthy controls population was also performed. Results novel...
Objectives: Autonomic dysfunction is a common symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis; however, it has been poorly researched. The purpose this study was to compare the clinical features, tumor occurrence, intensive care unit (ICU) admission, mechanical ventilation, imaging assessment, cerebrospinal fluid examination, disease severity, and immunotherapy in patients with anti-NMDAR encephalitis or without autonomic dysfunction. Methods: A retrospective diagnosed...
Aim: Monocyte-to-high-density lipoprotein ratio (MHR) recently emerged as an inflammatory marker and has been reported to be a novel prognostic indicator of cardiovascular diseases. However, the relationship between MHR prognosis acute ischemic stroke (AIS) remains unclear.
Abstract Aims To investigate the prevalence of overactive bladder (OAB) and assess its risk factors in 5‐ to 14‐year‐old Chinese children. Methods A cross‐sectional study OAB was performed by distributing 11 800 anonymous self‐administered questionnaires parents five provinces mainland China from July October 2018. The included questions on sociodemographics, history urinary tract infection (UTI), lower symptoms (LUTS), family LUTS, bowel symptoms, details about elimination communication...
Objectives The purpose of this study was to investigate the association neutrophil percentage-to-albumin ratio (NPAR) with severity at admission and discharge (short-term prognosis) in patients anti-N-methyl-D-aspartic acid receptor (NMDAR) encephalitis. Methods Multivariable logistic regression models such as NPAR were constructed based on univariable results. Receiver operating characteristic (ROC) curves, nomograms, concordance index (c-index) used evaluate efficacy assessing disease...
Despite extensive research, spinal cord injuries (SCI), which could cause severe sensory, motor and autonomic dysfunction, remain largely incurable. Oligodendrocytes oligodendrocyte precursor cells (ODC/OPC) play a crucial role in neural morphological repair functional recovery following SCI. We performed single-cell sequencing (scRNA-seq) on 59,558 from 39 mouse samples, combined with microarray data 164 SCI samples 3 uninjured samples. further validated our findings using large clinical...
Rationale: Pressure overload (PO)-induced heart failure (HF) is a global health burden with poor outcomes. Cardiomyocyte hypertrophy and capillary rarefaction are two features drivers of PO-induced HF. Metabolism altered in hypertrophic cardiomyocytes; however, the metabolites secreted by cardiomyocytes to paracrinally regulate density remain be identified. Methods: HF was established transverse aortic constriction mice. Metabolite secretion examined nontargeted metabolomics enzyme-linked...
This study aimed to investigate the effectiveness of continuous renal replacement therapy and hemoperfusion in acute severe organophosphorus pesticide poisoning patients. Fifty-eight patients who accepted Nangjing First Hospital, Medical University from January 2018 December 2022 were chosen as participants. They randomly divided into a control group research group. Both groups received conventional treatment, while combined with therapy. Relative group, had higher total rate, shorter coma...
Abstract Background TOAST subtype classification is important for diagnosis and research of ischemic stroke. Limited by experience neurologist time-consuming manual adjudication, it a big challenge to finish effectively. We propose novel active deep learning architecture classify TOAST. Methods To simulate the process neurologists, we drop valueless features XGB algorithm rank remaining ones. Utilizing framework, causal CNN, in which combines with mixed selection criterion optimize...
Associations between hyperhomocysteinemia and prognosis of stroke were seldom explored always indefinite. We therefore performed a study to elucidate the relationship homocysteine levels prognosis. Between 2008 2013, baseline data blood samples acute ischemic patients collected from Henan Province Stroke Registry. Using prospective cohort, scheduled follow-up, multivariable logistic regression analysis, associations among level neurological impairment outcomes, recurrence, all-cause death...
Abstract Gastrointestinal stromal tumors (GISTs) predominantly develop in the stomach. While nomogram offer tremendous therapeutic promise, there is yet no ideal comparison customized specifically for handling categorical data and model selection related gastric GISTs. (1) We selected 5463 patients with GISTs from SEER Research Plus database spanning 2000 to 2020; (2) proposed an advanced missing imputation algorithm designed variables; (3) constructed five Cox models, each employing...
To investigate the prevalence of spina bifida occulta (SBO) and its relationship with presence overactive bladder (OAB) in middle-aged elderly people China.
Presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP) mutations are responsible for autosomal dominant early-onset Alzheimer's disease (AD-EOAD). To analyze the phenotypes genotypes of EOAD patients, we performed comprehensive clinical assessments as well mutation screening PSEN1, PSEN2, exons 16 17 APP by Sanger sequencing in three Chinese families. We identified two novel PSEN1 (Y256N H214R) samples from these families, a de novo (G206V) patient with very sporadic...
Lower prognostic nutritional index (PNI) is related to the poor prognosis of cardiovascular diseases. However, little known about PNI and its relationship with cerebral venous sinus thrombosis (CVST).CVST patients were retrospectively identified from January 2013 till June 2019. Patients in acute / subacute phase selected as subjects. Poor was defined a modified Rankin Scale (mRS) 3-6. Multivariate logistic regression analysis used confirm if lower associated prognosis.A total 297 subjects...
Clinically, physicians collect the benchmark medical data to establish archives for a stroke patient and then add follow up regularly. It has great significance on prognosis prediction patients. In this paper, we present an interpretable deep learning model predict one-year mortality risk stroke. We design sub-modules reconstruct features from original clinical that highlight dissimilarity temporality of different variables. The consists Bidirectional Long Short-Term Memory (Bi-LSTM), in...