A5024900382- Cardiac electrophysiology and arrhythmias
- Nonlinear Dynamics and Pattern Formation
- Peroxisome Proliferator-Activated Receptors
- Nonlinear Photonic Systems
- Thyroid Disorders and Treatments
- Sesquiterpenes and Asteraceae Studies
- stochastic dynamics and bifurcation
- Immune Cell Function and Interaction
- Ion channel regulation and function
- Phytochemistry and Biological Activities
- Neural Networks Stability and Synchronization
- Immunotherapy and Immune Responses
- Cannabis and Cannabinoid Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrhythmias and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Stroke Rehabilitation and Recovery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Fluid Dynamics Simulations and Interactions
- earthquake and tectonic studies
- Neurological Disorders and Treatments
- E-commerce and Technology Innovations
The People's Hospital of Guangxi Zhuang Autonomous Region
2023-2024
Shanghai Jiao Tong University
2019-2021
University of California, Los Angeles
2020
Beijing Normal University
2019-2020
Jiangxi Agricultural University
2020
Pfizer (United States)
2011-2016
Yangtze University
2016
The Fourth People's Hospital
2012
Huizhou Central People's Hospital
2012
The First People's Hospital of Changde
2011
Inhibition of BACE1 to prevent brain Aβ peptide formation is a potential disease-modifying approach the treatment Alzheimer's disease. Despite over decade drug discovery efforts, identification brain-penetrant inhibitors that substantially lower CNS levels following systemic administration remains challenging. In this report we describe structure-based optimization series derived from an iminopyrimidinone scaffold. Application design in tandem with control physicochemical properties...
Purpose: Adverse reactions reported in patients treated with antibody-calicheamicin conjugates such as gemtuzumab ozogamicin (Mylotarg) and inotuzumab include thrombocytopenia sinusoidal obstruction syndrome (SOS). The objective of this experimental work was to investigate the mechanism for thrombocytopenia, characterize liver injury, identify potential safety biomarkers.Experimental Design: Cynomolgus monkeys were dosed intravenously at 6 mg/m2/dose once every 3 weeks a nonbinding conjugate...
The fatty liver hemorrhage syndrome in laying hens is a disease of lipid metabolism disorders. Importantly, energy sensor AMP-activated protein kinase (AMPK) plays an essential role homeostasis regulation lipid. current research aims to investigate the relationship between AMPK signaling pathway and hen hepatocytes explore underlying mechanisms. steatotic model was established treated with agonist AICAR inhibitor compound C. results showed that levels triglyceride, total cholesterol,...
Power systems are special multi-agent with nonlinear coupling function and symmetric structures. This paper extends these to a class of mismatched parameters, linear function, asymmetric structures investigates their velocity synchronization via sampled position data. The dynamics the agents is adopted as that generators while system supposed be complex. Two distributed consensus protocols designed, respectively, for without or communication delay. Necessary sufficient conditions based on...
A strain-based criterion for sediment fluidization under transient pressure loading is presented. The predicts that can be spontaneous, as opposed to incremental, and it triggered by a lowering—rather than buildup—of the pore pressure. examined verified experimentally. dam break simulated in laboratory flume, bed included half of flume initially containing water. Both visual observation extensive measurements within indicate occurrence massive failure throughout entire depth length bed....
Abstract Background Endothelium-dependent flow mediated dilation (FMD) and pulse-wave velocity (PWV), are used as measures of vascular health predictors cardiovascular risk in clinical studies, both age-dependent. Numbers circulating endothelial microparticles (EMPs) progenitor cells (EPCs) also associated with risk, but independent age humans. The use these measurements for pre-clinical assessment drug safety efficacy non-human primates (NHPs) may promote the translation drug-induced...
Cardiac alternans, a period-2 behavior of excitation and contraction the heart, is precursor ventricular arrhythmias sudden cardiac death. One form alternans repolarization or action potential duration alternans. In tissue, can be spatially in-phase, called concordant out-of-phase, discordant (SDA). SDA, border between two out-of-phase regions node in one-dimensional cable nodal line two-dimensional tissue. this study, we investigate stability dynamics nodes lines driven by voltage...
Duhaldea pterocaula (Franch.) Anderb, also known as Inula Franch ( I. ), is a folk medicine of the Yi nationality in China. The plants display various biological activities, including anti-nociceptive and anti-inflammatory properties. has been traditionally used for treatment bronchitis, vasculitis, dizziness. However, very few studies have reported on pharmacology . present study aims to characterize properties explore underlying mechanism. was extracted by 95% ethanol further portioned...
The rural revitalization strategy is taken as an important measure to solve the problem of agriculture, areas and farmers, a powerful starting point for realizing this agricultural e-commerce. vigorous development agriculturale-commerce helps farmers eliminatepoverty, increase income, promote industrialization. While bringing new opportunities, it also faced with challenges, mainly including lag related supporting construction, imbalance regional development, unsustainability structure. With...
<title>Abstract</title> Background Unplanned readmission among patients with Chronic Obstructive Pulmonary Disease (COPD) is increasingly prevalent and imposes significant clinical economic burdens. The aim of this study was to investigate the influencing factors unplanned in COPD within 1 year after discharge, construct a risk prediction model evaluate its effect. Methods We conducted prospective observational on 719 individuals diagnosed at HePu People's Hospital from January 2023 May...
Abstract Various behaviours of nonlinear wave propagation and competition have been discussed investigated extensively meticulously, especially when the media are homogeneous. However, corresponding studies in heterogeneous much scarcer. In this paper, spontaneously generated waves from one-dimensional oscillatory media, modelled by complex Ginzburg–Landau equations with spatially varied controlling parameters, investigated. An unexpected homogeneous train clearly emerges under certain...
Background: Non human primates develop cardiovascular disease over decades. Whether the progression of vascular dysfunction with age is like that observed in humans unclear. We hypothesize that, humans, monkeys show age-related reductions flow-mediated dilation (FMD, an index endothelium-dependent reactivity) and increases pulse-wave velocity (PWV, aortic stiffness). also explored a potential relationship between effects circulating biomarkers endothelial health, microparticles (EMP)...
Background: Rosiglitazone, 6 hours after dosing, rapidly increases endothelial-dependent flow mediated dilation (FMD) in subjects with healthy endothelium. Whether this acute improvement FMD occurs the presence of endothelial dysfunction is unknown. We test hypothesis that rosiglitazone acutely improves senescent monkeys and coincides favorable changes circulating biomarkers health, progenitor cells (EPC) microparticles (EMP). Euglycemic were used to avoid rosiglitazone’s glucose-lowering...