A5031164652- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- Advanced Glycation End Products research
- Immune Cell Function and Interaction
- Liver physiology and pathology
- T-cell and B-cell Immunology
- Toxoplasma gondii Research Studies
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Sphingolipid Metabolism and Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autophagy in Disease and Therapy
- 2D Materials and Applications
- Cancer Cells and Metastasis
- Organ Transplantation Techniques and Outcomes
- Immune Response and Inflammation
- Aquaculture Nutrition and Growth
- Radiomics and Machine Learning in Medical Imaging
Heilongjiang University of Chinese Medicine
2025
National Institute for Parasitic Diseases
2025
Chongqing Medical University
2005-2024
Shandong First Medical University
2023-2024
Peking Union Medical College Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Wuhan University
2023-2024
Xiamen University
2023-2024
Dalian Naval Academy
2023-2024
Beijing Friendship Hospital
2024
Abstract Multiferroic materials offer a promising avenue for manipulating digital information by leveraging the cross-coupling between ferroelectric and ferromagnetic orders. Despite ferroelectricity has been uncovered ion displacement or interlayer-sliding, one-unit-cell of multiferroic design wafer-scale synthesis have yet to be realized. Here we develope an interface modulated strategy grow 1-inch non-layered chromium sulfide with unidirectional orientation on industry-compatible c -plane...
Abstract Seawater electrolysis holds tremendous promise for the generation of green hydrogen (H 2 ). However, system seawater‐to‐H faces significant hurdles, primarily due to corrosive effects chlorine compounds, which can cause severe anodic deterioration. Here, a nickel phosphide nanosheet array with amorphous NiMoO 4 layer on Ni foam (Ni P@NiMoO /NF) is reported as highly efficient and stable electrocatalyst oxygen evolution reaction (OER) in alkaline seawater. Such /NF requires...
Cell-laden bioprinting is a promising biofabrication strategy for regenerating bioactive transplants to address organ donor shortages. However, there has been little success in reproducing transplantable artificial organs with multiple distinctive cell types and physiologically relevant architecture. In this study, an omnidirectional printing embedded network (OPEN) presented as support medium 3D printing. The state-of-the-art due its one-step preparation, fast removal, versatile ink...
Summary Testosterone (T) and vitamin D (VD) interact in androgen deficient men, however, this interaction subsequent semen quality bone mineral density (BMD) status is not clear infertile men. Our objective was to investigate T, VD, quality, BMD their relationships Chinese We conducted a cross‐sectional study of 559 men aged 20–40 years, including 195 fertile 9 with known risk factors for osteoporosis (WR) 355 without (WOR). WOR constituted 314 oligo‐, astheno‐, teratospermic or normospermic...
Preeclampsia (PE) is a major cause of maternal mortality and morbidity worldwide. Although there has been great progress in the understanding PE, exact for disease development still unclear. Recently, studies showed that genetic deletion ELABELA (ELA, also known as APELA) could induce PE-like symptoms mice. However, role ELA PE remains elusive. Our objective was to measure changes levels serum, urine, placenta from preeclamptic pregnant women healthy evaluate correlation between occurrence...
Abstract Methods accurately predicting the responses of colorectal cancer (CRC) and liver metastasis (CRLM) to personalized chemotherapy remain limited due tumor heterogeneity. This study introduces an innovative patient‐derived CRC CRLM model for preclinical investigation, utilizing 3d‐bioprinting (3DP) technology. Efficient construction homogeneous in vitro 3D models CRC/CRLM is achieved through application primary cells bioprinting with bioink. Genomic histological analyses affirm that...
Two-dimensional (2D) heterostructures with ferromagnetism and ferroelectricity provide a promising avenue to miniaturize the device size, increase computational power, reduce energy consumption. However, direct synthesis of such eye-catching has yet be realized up now. Here, we design two-step chemical vapor deposition strategy growth Cr2S3/WS2 vertical atomically sharp clean interfaces on sapphire. The interlayer charge transfer periodic moiré superlattice result in emergence...
Abstract Post-hepatectomy liver dysfunction is a life-threatening morbidity that lacks efficient therapy. Bioactive lipids involved in macrophage polarization crucially regulate tissue injury and regeneration. Herein, we investigate the key bioactive mediate cytotherapeutic potential of polarized-macrophage for post-hepatectomy dysfunction. Untargeted lipidomics identified elevation ceramide (CER) metabolites as signature lipid species relevant to M1/M2 mouse bone-marrow-derived-macrophages...
The tumor immune microenvironment significantly affects progression, metastasis, and clinical therapy. Its basic cell components include tumor-associated endothelial cells, fibroblasts, macrophages, all of which constitute the stroma microvascular network. However, functions stromal cells have not yet been fully elucidated. three-dimensional (3D) model created by 3D bioprinting is an efficient way to illustrate cellular interactions in vitro. bioprinted has used explore effects on...
Dipeptidyl peptidase-4 inhibitors (DPP-4I), key regulators of the actions incretin hormones, exert anti-hyperglycemic effects in type 2 diabetes mellitus (T2DM) patients. A major unanswered question concerns potential ability DPP-4I to improve intrahepatic lipid (IHL) content nonalcoholic fatty liver disease (NAFLD) The aim this study was evaluate sitagliptin on IHL NAFLD patients.A prospective, 24-week, single-center, open-label, comparative enrolled 68 Chinese patients with T2DM. Subjects...
Background Natural killer (NK) cells activation has been reported to contribute inflammation and liver injury during hepatitis B virus (HBV) infection both in transgenic mice patients. However, the role of NK process HBV-associated hepatocellular carcinoma (HCC) development not addressed. Killer cell immunoglobulin-like receptors (KIRs) are involved regulating through recognition specific human leukocyte antigen (HLA) class I allotypes. Methodology/Principal Findings To investigate whether...
Overload of palmitic acids is linked to the dysregulation ceramide metabolism in nonalcoholic steatohepatitis (NASH), and ceramides are important bioactive lipids mediating lipotoxicity acid NASH. However, much remains unclear about role ceramidases that catalyze hydrolysis By analyzing National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database, we found alkaline ceramidase 3 (ACER3) upregulated livers patients with Consistently, Acer3 mRNA levels its...
Introduction This study aims to establish the fingerprint spectra of Kai-Xin-San (KXS) and investigate its spectrum-effect relationship in treating Alzheimer’s disease (AD). Methods Initially, fingerprints 15 batches KXS were established analyzed using HPLC, with method’s precision, stability, repeatability thoroughly evaluated. Subsequently, effects assessed an olfactory escape memory experiment, utilizing Aβ 42 transgenic drosophila as a model. Finally, between improvement was analyzed,...
<title>Abstract</title> Background <italic>Toxoplasma gondii</italic> (<italic>T. gondii</italic>) can cause severe damage to immunodeficient hosts, and also compromise brain structure function in immunocompetent hosts during latent infection. In China, the two different isolates, <italic>Chinese I</italic> (<italic>ToxoDB#9</italic>) III</italic> are dominant epidemic strains widely spreading humans domestic animals lead infection host tissues, but comparison of their manipulation patterns...
Background. Augmenter of liver regeneration (ALR), which was identified originally for its crucial role in promoting hepatocyte proliferation, is expressed both the and kidney. Protective effects ALR have been demonstrated experimental models acute failure. In present study, we investigated effect on renal ischaemia/reperfusion (I/R) injury possible mechanisms action. Methods. Male Sprague–Dawley rats were subjected to ischaemia 60 min then administered with either saline or recombinant...
Abstract Mycobacterium tuberculosis , the leading causative agent of tuberculosis, remains one most deadly infectious pathogens. PE_PGRS proteins become a new focus as their species specificity in mycobacteria, especially pathogenic mycobacteria. Despite intensive research, are still mysterious aspect mycobacterial pathogenesis with unknown mechanism. Herein, we focused on member from M. PE_PGRS62, characterized by surface‐exposed protein function disrupting phagolysosome maturation....
Background and Aims: Although autologous bone marrow stem cell (BMSC) transplantation is an effective treatment for liver cirrhosis, there are few reports describing the optimal delivery route number of injected BMSCs. Methods: A literature search was conducted using PubMed, ISI Web Science, Cochrane Central Register Controlled Trials, EBSCO. meta-analysis performed to assess effect BMSCs on coagulation function indices. Subgroup analysis based BMSCs, route, length follow-up. Results: total...
The field of bone tissue engineering (BTE) has witnessed a revolutionary breakthrough with the advent three-dimensional (3D) bioprinting technology, which is considered an ideal choice for constructing scaffolds regeneration. key to realizing scaffold biofunctions selection and design appropriate bioink, existing bioinks have significant limitations. In this study, composite bioink based on natural polymers (gelatin alginate) liver decellularized extracellular matrix (LdECM) was developed...
Abstract Background Toxoplasma gondii can cause severe damage to immunodeficient hosts, and also compromise brain structure function in immunocompetent hosts during latent infection. In China, the two different isolates, Chinese I ( ToxoDB#9 ) III are dominant epidemic strains widely spreading humans domestic animals lead infection host tissues, but comparison of their manipulation patterns mechanisms remains unclear. Methods Tachyzoites TgWh6 (Wh6) strain TgCtLHG (LHG) were used for...
Cholangiocarcinoma (CCA) is one of the most aggressive malignancies, lacking novel diagnostic and prognostic biomarkers. Exosome noncoding RNAs (ncRNA) were previously proposed as a potential source biomarkers in several cancers. This study aimed to interpret value specific bile-derived ncRNA predictors for early diagnosis prognosis CCA.We recruited 100 patients who received endoscopic retrograde cholangiopancreatography at our hospital bile duct obstruction due CCA (n = 50) biliary stone...