A5103092984- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Oral and Maxillofacial Pathology
- Microbial Inactivation Methods
- Tracheal and airway disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Toxin Mechanisms and Immunotoxins
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Medical Imaging and Pathology Studies
- Genetic Syndromes and Imprinting
- Radiomics and Machine Learning in Medical Imaging
- Voice and Speech Disorders
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Endoplasmic Reticulum Stress and Disease
- Biosimilars and Bioanalytical Methods
- Chronic Myeloid Leukemia Treatments
- Nanoplatforms for cancer theranostics
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2016-2025
Hubei University of Technology
2025
University Radiology
2019
Huazhong University of Science and Technology
2014-2017
Tongji Hospital
2014-2017
First Affiliated Hospital Zhejiang University
2015
Jiangsu Provincial Center for Disease Control and Prevention
2014
Fudan University
2014
Taizhou People's Hospital
2012
Significance Multiple myeloma (MM) is one of the most common hematological malignancies. Developing an effective treatment strategy for refractory/relapsed (R/R) MM represents a major challenge. In this trial, 17 R/R patients, who had previously experienced multiple lines treatments, received chimeric antigen receptor modified T (CAR T) cell preparation targeting two epitopes BCMA, and remarkable overall response 88.2% was achieved. This work confirms feasibility importance CAR therapy in...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable malignancy, with an only 6% 5-year relative survival rate. The dismal therapeutic effect attributed to chemotherapy resistance and unique pathophysiology abundant inflammatory cytokines abnormal hyperplasia extracellular matrix (ECM). Based on theory that bone marrow mesenchymal stem cells (BM-MSCs) can influence tumorous microenvironment malignant growth PDAC, we employed exosomes (Exos) derived from BM-MSCs as...
Abstract The response rate of pancreatic cancer to chemotherapy or immunotherapy is low. Although minimally invasive irreversible electroporation (IRE) ablation a promising option for irresectable cancers, the immunosuppressive tumour microenvironment that characterizes this type enables recurrence. Thus, strengthening endogenous adaptive antitumour immunity critical improving outcome therapy and post-ablation immune therapy. Here we present hydrogel microsphere vaccine amplifies anti-cancer...
Fibroblast growth factor 9 (Fgf9) is a well-known that regulates bone development; however, its function in homeostasis still unknown. Previously, we identified point mutation the FGF9 gene (p.Ser99Asn, S99N) and generated an isogeneic knock-in mouse model, which revealed this loss-of-function impaired early joint formation was responsible for human multiple synostosis syndrome 3 (SYNS3). Moreover, newborn adult S99N mutant mice exhibited significantly increased mass, suggesting Fgf9 also...
Objectives The purpose of our study is to investigate whether diffusion-weighted imaging (DWI) useful for monitoring the therapeutic response after neoadjuvant chemotherapy in osteosarcoma long bones. Materials and methods Conventional magnetic resonance (MRI) DWI were obtained from 35 patients with histologically proven osteosarcomas. MR examinations performed all before 4 courses preoperative chemotherapy. Apparent diffusion coefficients (ADC) measured. degree tumor necrosis was assessed...
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy with limited treatment options and a dismal prognosis. The tumor immune microenvironment (TIME) crucial for iCCA progression, yet its comprehensive characterization remains incomplete. This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze cell populations in fresh samples adjacent peritumor tissues. Notably, NK percentages significantly decreased lesions compared Conversely, enrichment...
Personalized and novel evidence-based clinical treatment strategy consulting for colorectal cancer has been available through various artificial intelligence (AI) supporting systems such as Watson Oncology (WFO) from IBM. However, the potential effects of this tool in care have not thoroughly explored real-world studies. This research aims to investigate concordance between recommendations patients made by WFO a multidisciplinary team (MDT) at major comprehensive gastrointestinal center. In...
Background The main objective of this study was to analyze the effects KRAS/TP53 mutation status and tumor sideness on immune microenvironment colorectal cancer using integrated scRNA-seq data. Methods A total 78 datasets, comprising 42 treatment-naive tumors, 13 adjacent tissues 23 normal mucosa were included. Standardized Seurat procedures applied identify cellular components with canonical cell marks. batch-effect assessed corrected harmony algorithm. scMetabolism algorithm used for...
Radiofrequency ablation (RFA) and cryoablation are minimally invasive treatments for renal cell carcinoma (RCC). However, their comparative efficacy remains under evaluation. This study aims to compare overall survival (OS) cancer-specific (CSS) outcomes using data from the Surveillance, Epidemiology, End Results (SEER) database. retrospective cohort included patients diagnosed with T1a-bN0M0 RCC SEER database (2004-2018). Propensity score matching was used control confounders, including...
Numerous studies have recently suggested that miRNAs contribute to the development of various types human cancer as well their proliferation and metastasis. The aim this study was investigate functional significance miR-126 identify its possible target genes in osteosarcoma (OS) cells. Here, we found expression level reduced cells comparison with adjacent normal tissues. enforced able inhibit cell U2OS MG62 cells, while antisense oligonucleotides (antisense miR-126) promoted proliferation....
Human multiple synostoses syndrome (SYNS) is an autosomal dominant disorder characterized by joint fusions. We previously identified a point mutation (S99N) in FGF9 that causes human SYNS3. However, the physiological function of during development and comprehensive molecular portraits SYNS3 remain elusive. Here, we report mice harboring S99N Fgf9 develop curly tail phenotype partially or fully fused caudal vertebrae limb joints, which mimic major phenotypes patients. Further study reveals...
To evaluate a 3D-printed coplanar template for iodine-125 seed implantation therapy in patients with pancreatic cancer.A retrospective analysis of our database was performed, and total 25 cancer who underwent between January 2014 November 2017 were analyzed. Of these, 12 implantations assisted by (group A), 13 performed freehand selected as control group B). A 3D designed printed according to preoperative CT scan treatment planning system. The seeds then implanted using the guide. Dosimetric...
Abstract Background This study intends to investigate the immunological effects of tumor ablation with irreversible electroporation (IRE). Methods We evaluated systemic immune response in patients hepatocellular carcinoma (HCC) after IRE treatment. Furthermore, we analyzed infiltrating T lymphocytes and level serum cytokines control groups tumor-bearing mice. Results observed that induced an increase WBC, neutrophil monocyte counts a decrease lymphocyte count 1 day post-IRE returned baseline...
The treatment of malignant stenosis involving the carina or bronchi is challenging due to complicated anatomy with individual variation, which makes it necessary customize stents for each patient. Therefore, this study aims evaluate feasibility a novel metallic segmented airway stent customized aid three-dimensional (3D) printing such cases.The were individually 3D printed mold based on computed tomography (CT) images according anatomical features airway. A design was applied junction part...
Capability of tumor cells to impede immune response are largely associated with their interaction and regulation CD4+CD25+ forkhead box transcription factor (Foxp)3+ regulatory T (Treg) cells, which suppress cytotoxic cell-mediated immunity in the microenvironment. Foxp3 level is critical for development phenotypic maintenance Treg, regulated by transcriptional control epigenetic modification. Here, we showed that higher percentage intratumoral Treg was positively correlated lower promoter...
The aim of the study is to evaluate technique, safety, efficacy, and clinical value computed tomography (CT)-guided percutaneous coaxial biopsy combined with microwave ablation (MWA) therapy for pulmonary tumors.CT-guided MWA was performed on 27 tumors in 23 patients who received treatment at our hospital from August 2014 November 2017. were followed up 2 42 months. outcomes evaluated plain contrast spiral CT scans.After treatment, lower density values than baseline observed ablated area....
ABSTRACT Aims: To compare the diagnostic efficacy and safety of CT-guided percutaneous core needle biopsy (CNB) fine-needle aspiration (FNA) for pancreatic lesions. Methods Material: A total 176 patients with lesions who visited our hospital between January 2016 March 2021 were retrospectively analyzed. They divided into three groups: FNA group (<1.5 cm lesion great vessels necessitating FNA), B, CNB (the latter two ≥1.5 FNA). The sensitivity, specificity, positive predictive value,...