A5100692276- Food Allergy and Anaphylaxis Research
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Food Safety and Hygiene
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Allergic Rhinitis and Sensitization
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Virus-based gene therapy research
- Functional Brain Connectivity Studies
- Consumer Attitudes and Food Labeling
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Contact Dermatitis and Allergies
- Pharmacological Effects of Natural Compounds
- Silymarin and Mushroom Poisoning
- Phagocytosis and Immune Regulation
- Medicinal plant effects and applications
Nanchang University
2019-2025
State Key Laboratory of Food Science and Technology
2024-2025
China National Center for Food Safety Risk Assessment
2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Zhongshan Hospital
2021-2024
Fudan University
2021-2024
Sun Yat-sen University
2020-2024
Ministry of Education of the People's Republic of China
2024
Wuyi University
2020-2023
National Clinical Research Center for Digestive Diseases
2021-2023
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy with limited treatment options and a dismal prognosis. The tumor immune microenvironment (TIME) crucial for iCCA progression, yet its comprehensive characterization remains incomplete. This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze cell populations in fresh samples adjacent peritumor tissues. Notably, NK percentages significantly decreased lesions compared Conversely, enrichment...
Abstract Reversing the highly immunosuppressive tumor microenvironment (TME) is essential to achieve long-term efficacy with cancer immunotherapy. Despite impressive clinical response checkpoint blockade in multiple types of cancer, only a minority patients benefit from this approach. Here, we report that oncolytic virus M1 induces immunogenic cell death and subsequently restores ability dendritic cells prime antitumor T cells. Intravenous injection disrupts immune tolerance privileged TME,...
The anaphylaxis triggered by oral ingestion of food allergens can lead to disruptions in tryptophan metabolism, consequently impairing intestinal immune homeostasis.
Silibinin, a major polyphenol in milk thistle, has been reported to have multiple pharmacological activities; therefore, there is an urgent need well understand how silibinin works on inflammation-associated skin diseases. We herein designed 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated inflammation test its inhibitory effects. It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced...
CD276 is an emerging immune checkpoint molecule that has been implicated in various cancers. However, its specific role hepatocellular carcinoma (HCC) remains unclear. This study examined the impact of on patient prognosis and tumor microenvironment (TME).
The poliovirus receptor (PVR) is a member of the immunoglobulin superfamily (Ig SF) and essential for promotion cancer cell proliferation invasion. However, correlation between PVR expression prognosis as well immune infiltration in hepatocellular carcinoma (HCC) remains unclear. level was quantified using Tumor Immunity Evaluation Resource (TIMER) Sangerbox. Gene Expression Omnibus (GEO) database used to validate expression. receiver operating characteristic (ROC) curve evaluate feasibility...
Abstract Oxaliplatin is commonly used as the first‐line chemotherapeutic agent for advanced hepatocellular carcinoma (HCC). Unfortunately, acquired resistance, limits effectiveness of oxaliplatin and underlying mechanisms remain unknown. Therefore, we explored role NOD‐like receptor protein 3 (NLRP3)/IL‐1β in mediating resistance HCC. We observed that NLRP3/IL‐1β expression was much higher oxaliplatin‐resistant HCC cells. To further understand its impact on drug knocked down NLRP3 it...
The goal of this study was to evaluate the performance a convolutional neural network (CNN) with preoperative MRI and clinical factors in predicting treatment response unresectable hepatocellular carcinoma (HCC) patients receiving hepatic arterial infusion chemotherapy (HAIC). A total 191 HCC who underwent HAIC our hospital between May 2019 March 2022 were retrospectively recruited. We selected InceptionV4 from three representative CNN models, AlexNet, ResNet, InceptionV4, according...
Background: Patients with hepatocellular carcinoma (HCC) portal vein tumor thrombus (PVTT) present a poor prognosis. Current systemic therapies offer limited benefits. Hepatic artery infusion chemotherapy (HAIC) is local regional treatment for advanced HCC, particularly in selected patients such as PVTT or high intrahepatic burden. Objectives: The purpose of this study to retrospectively evaluate the efficacy and safety HAIC combined anti-PD-1 immunotherapy HCC PVTT, explore factors related...
Understanding and monitoring the cross-contamination of food allergens is crucial for safeguarding public health ensuring safety. Food allergen risk assessment, derived from classical toxicological principles, can identify quantify allergies. This study aimed to investigate wheat allergic reactions prepackaged foods China through utilization assessment. A total 575 products have been surveyed, wheat/gluten, milk egg were major labelled on products. According voluntary incidental trace...
Background The aim of this study was to derive and validate a decision tree model predict disease-specific survival after curative resection for primary cholangiocarcinoma (CCA). Method Twenty-one clinical characteristics were collected from 482 patients CCA. A total 289 randomly allocated into training cohort 193 validation cohort. We built three models based on 5, 12, 21 variables, respectively. Area under curve (AUC), sensitivity, specificity used comparison the 0.5-, 1-, 3-year...
Abstract Background There was little known on how the interaction effect between obesity and current smoking affected incidence of hypertension. The aim this study to investigate body mass index (BMI) modified Methods Data were obtained from China Health Nutrition Survey (CHNS). According WHO recommendations for Chinese people, normal weight, overweight, defined using BMI cutoff values 18.5 kg/m 2 , 23.0 27.5 kg/m, respectively. Current smokers as having smoked at least 100 cigarettes or...
<bold>A10</bold>was selected to elucidate the anti-inflammatory mechanism at transcriptional level, suggesting its potential serve as a novel agent.