A5100401321- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Echinoderm biology and ecology
- Gallbladder and Bile Duct Disorders
- Insect Resistance and Genetics
- Genetic Mapping and Diversity in Plants and Animals
- Glaucoma and retinal disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Aquaculture Nutrition and Growth
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Genetic and phenotypic traits in livestock
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Facial Trauma and Fracture Management
- Plant Virus Research Studies
- Obesity, Physical Activity, Diet
- Cancer-related gene regulation
- Bariatric Surgery and Outcomes
- Literacy, Media, and Education
- Dental Implant Techniques and Outcomes
- Machine Learning in Bioinformatics
- Marine Ecology and Invasive Species
- Invertebrate Immune Response Mechanisms
- Milk Quality and Mastitis in Dairy Cows
Nanchang University
2015-2023
Ministry of Agriculture and Rural Affairs
2020-2023
Dalian Ocean University
2010-2023
Zhongshan Hospital
2020-2022
Fudan University
2020-2022
Central South University
2019-2021
Third Xiangya Hospital
2021
Capital Medical University
2021
Sun Yat-sen University
2006-2020
The First Affiliated Hospital, Sun Yat-sen University
2020
Abstract Background Genome wide association studies (GWAS) on residual feed intake (RFI) and its component traits including daily dry matter (DMI), average gain (ADG), metabolic body weight (MWT) were conducted in a population of 7573 animals from multiple beef cattle breeds based 7,853,211 imputed whole genome sequence variants. The GWAS results used to elucidate genetic architectures the efficiency related cattle. Results DNA variant allele substitution effects approximated bell-shaped...
Abstract Background Genome wide association studies (GWAS) were conducted on 7,853,211 imputed whole genome sequence variants in a population of 3354 to 3984 animals from multiple beef cattle breeds for five carcass merit traits including hot weight (HCW), average backfat thickness (AFAT), rib eye area (REA), lean meat yield (LMY) and marbling score (CMAR). Based the GWAS results, genetic architectures elucidated. Results The distributions DNA variant allele substitution effects approximated...
SWItch/Sucrose NonFermentable (SWI/SNF) is a set of multi-subunits chromatin remodeling complexes, playing important roles in variety biological processes. Loss-of-function mutations the genes encoding SWI/SNF subunits have been reported more than 20% human cancers. Thus, it was widely considered as tumor suppressor past decade. However, recent studies that some complexes were amplified and play oncogenic In present study, we summarized genetic alteration spectrum firstly systematically...
The application of polydopamine (PDA)-modified titanium dioxide nanoparticles (nano-TiO2@PDA) as a new blue-light-activated tooth whitening material was discussed for the first time. Compared with classical clinical agent (peroxide, hydrogen peroxide, and carbamide peroxide), nano-TiO2@PDA-based treatment not only had similar effect but also showed remarkably less damage on enamel structure. Essentially, highly effective nondestructive could thus be realized accordingly. toxicity...
To determine whether magnetic resonance (MR) imaging heating guidewire-mediated radiofrequency (RF) hyperthermia could enhance the therapeutic effect of gemcitabine and 5-fluorouracil (5-FU) in a cholangiocarcinoma cell line local deposit doses chemotherapeutic drugs swine common bile duct (CBD) walls.The animal protocol was approved by institutional care use committee. Green fluorescent protein-labeled human cells cholangiocarcinomas 24 mice were treated with (a) combination therapy...
Background: The clinical significance of Albumin-to-Alkaline Phosphatase Ratio (AAPR) has been discussed in hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). aim this study is to clarify the prognostic value AAPR patients with combined (cHCC-CCA). Methods: A total 267 pathologically diagnosed as Allen type C cHCC-CCA our institution were retrospectively enrolled randomly divided into training (N=187) cohort validation (N=80) cohort. was evaluated validated. An AAPR-based nomogram...
Abstract MicroRNAs (miRNAs) are important effectors in mediating host–pathogen interaction. In this report, coelomocytes miRNA libraries of three Japanese sea cucumbers Apostichopus japonicus were built by Illumina ® Hiseq2000 from different time points after lipopolysaccharide challenge (at 0 h, 6 h and 12 h). The clean data received high throughput sequencing used to sequences analysis. Referenced the Strongylocentrotus purpuratus genome, 38 conserved miRNAs found candidates predicted...
Few studies have focused on the prevalence of abdominal obesity in Chinese middle-aged and older adults with a normal body mass index (BMI). Furthermore, it is still unclear whether an independent risk factor for type 2 diabetes mellitus (T2DM). Participants BMI are usually neglected during assessments obesity-associated T2DM since current recommendations medical interventions mainly overall rather than fat deposition patterns.In this study, 7942 normal-BMI participants aged over 45 years...
Long noncoding RNA (lncRNA) plays crucial roles in various biological processes of different cancers, especially acting as a competing endogenous (ceRNA). However, the role lncRNA-mediated ceRNA Wilms tumor (WT), which is most common malignant kidney cancer children, remains unknown. In present study, sequence profiles and clinical data 125 patients with WT consisting 119 6 normal tissues from Therapeutically Applicable Research To Generate Effective Treatments database were analyzed. A...
Autism spectrum disorders (ASDs) are prevalent neurobiological conditions with complicated causes worldwide. Increasing researcher awareness of ASD and accumulated evidence suggest that the development may be strongly linked to dysbiosis gut microbiota. In addition, most current studies have compared autistic children neurotypical or patients before after antibiotic treatment. Treatment autism traditional Chinese medicine (TCM) has increasingly been promoted, but relationship between its...
Abstract Nasopharyngeal carcinoma is a common malignancy in Southeast Asian countries, and genetic background well-known component of the complexity underlying its tumorigenic process. We have mapped nasopharyngeal susceptibility locus to chromosome 4p15.1-q12 previous linkage study on pedigrees. In this provided communication, we screened all genes region, with focus exons, promoters, exon-intron boundary identify carcinoma–associated mutations or functional variants. Importantly, found...
Background The aim of this study was to derive and validate a decision tree model predict disease-specific survival after curative resection for primary cholangiocarcinoma (CCA). Method Twenty-one clinical characteristics were collected from 482 patients CCA. A total 289 randomly allocated into training cohort 193 validation cohort. We built three models based on 5, 12, 21 variables, respectively. Area under curve (AUC), sensitivity, specificity used comparison the 0.5-, 1-, 3-year...
To identify the potential genes in human trabecular meshwork (TM) related to primary open-angle glaucoma (POAG). First, long noncoding RNA (LncRNA) and mRNA expression profiles TM samples from 4 control subjects POAG patients were accessed by microarray analyses. Then, twenty lncRNAs validated real-time quantitative PCR same Finally, eight highly expressed further tested 8 normal controls 19 patients. Expression data normalized analyzed using R software. Pathway analyses performed Gene...
Obesity is a metabolic syndrome characterized by abnormal lipid deposition and energy imbalance. CD38 single-chain transmembrane glycoprotein widely expressed in variety of cell types. The roles skeletal muscle brown fat deficiency under HFD-induced obesity remain unknown. In this study, we established model with HFD examined the changes metabolites metabonomics. Our results showed that expression was increased after treatment. Moreover, metabonomics significantly altered metabolism,...
Lactobacillus plantarum WLPL04, a novel strain, was isolated from breast milk sample healthy woman and demonstrated several probiotic functions. Here, we present the draft genome sequence of this which contains 3,192,587 bp, G+C content 44.52%, 3,158 protein-coding genes, 53 tRNA genes.
The combination of mRNA and lncRNA profiles for establishing an integrated mRNA-lncRNA prognostic signature has remained unexplored in cholangiocarcinoma (CCA) patients. We utilized a training dataset 36 samples from Cancer Genome Atlas validation cohort (GSE107943) 30 Gene Expression Omnibus. Two mRNAs (CFHR3 PIWIL4) 2 lncRNAs (AC007285.1 AC134682.1) were identified to construct the through univariate Cox regression (P-value = 1.35E-02) multivariable analysis 3.07E-02). Kaplan-Meier curve...
Abstract Background To identify the potential genes in human trabecular meshwork (TM) related to primary open-angle glaucoma (POAG). At first, long noncoding RNA (LncRNA) and mRNA expression profiles TM samples from 4 control subjects POAG patients were accessed by microarray analyses. Then, twenty lncRNAs validated real-time quantitative PCR same Finally, eight highly further tested 8 normal controls 19 patients. Expression data normalized analyzed using R software. Pathway analyses...