A5100340663- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Epigenetics and DNA Methylation
- Axon Guidance and Neuronal Signaling
- Reproductive Biology and Fertility
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Surgical Treatments
- Lipid metabolism and disorders
- Renal and related cancers
- Thyroid Disorders and Treatments
- Climate Change and Health Impacts
- Endometrial and Cervical Cancer Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Ovarian function and disorders
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Genetic Syndromes and Imprinting
Icahn School of Medicine at Mount Sinai
2015-2025
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2023-2025
Roche (China)
2025
Chongqing Medical and Pharmaceutical College
2024
University of Cambridge
2021-2024
Southern University of Science and Technology
2024
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2009-2024
Universitas Prima Indonesia
2023
Abstract The relationship between the human placenta—the extraembryonic organ made by fetus, and decidua—the mucosal layer of uterus, is essential to nurture protect fetus during pregnancy. Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate decidua, transforming maternal arteries into high-conductance vessels 1 . Defects in invasion arterial transformation established early pregnancy underlie common disorders such as pre-eclampsia 2 Here we have generated a...
The placenta is the principal regulator of in utero environment, and disruptions to this environment can result adverse offspring health outcomes. To better characterize impact perturbations, we assessed influence known environmental pollutants on expression microRNA (miRNA) placental samples collected from National Children's Study (NCS) Vanguard birth cohort. This study analyzed 654 miRNAs 110 term placentas. Environmental measured these placentas included dichlorodiphenyldichloroethylene...
Background Diabetes mellitus (DM) increases the risk of adverse maternal and neonatal outcomes, optimization glycemic control during pregnancy can help mitigate risks associated with diabetes. However, studies seldom focus precisely on blood glucose level prior to pregnancy. We aimed evaluate associations between preconception fasting plasma (FPG) subsequent outcomes. Methods findings conducted a population-based retrospective cohort study among 6,447,339 women aged 20–49 years old who...
ABSTRACT Two recently developed models, trophoblast organoids and stem cells (TSCs), are useful tools to further the understanding of human placental development. Both differentiate from villous cytotrophoblast (VCT) either extravillous (EVT) or syncytiotrophoblast (SCT). Here, we compare transcriptomes miRNA profiles these models identify which they resemble in vivo. Our findings indicate that TSCs do not readily undergo SCT differentiation closely at base cell columns where EVT derives. In...
In the mammalian ovary, primordial follicles are generated early in life and remain dormant for prolonged periods. Their growth resumes via follicle activation, they continue to grow until preovulatory stage under regulation of hormones factors, such as estrogen, FSH, IGF-1. Both FSH IGF-1 activate phosphatidylinositol-3 kinase (PI3K)/Akt (acute transforming retrovirus thymoma protein kinase) signaling pathway granulosa cells (GCs), yet it remains inconclusive whether PI3K is crucial growth....
Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been developed as a new method treating diseases the peripheral nervous system. While netrin-1 is critical molecule for axonal path finding and nerve growth, it may also affect vascular network formation. Here, we investigated effect transplanting BMSCs that produce in rat model sciatic crush injury. We introduced injury, then injected 1×10(6) infected by recombinant adenovirus expressing Ad5-Netrin-1-EGFP or culture medium...
In vitro fertilization-embryo transfer (IVF-ET) stands as one of the most prevalent treatments for infertility. During an IVF-ET cycle, time interval between trigger shot and oocyte pickup (OPU) is a pivotal period follicular maturation, which determines mature oocytes yields impacts success subsequent procedures. However, accurately predicting this severely hindered by variability clinicians'experience that often leads to suboptimal retrieval rate. To address challenge, we propose ILETIA,...
After the global approval of atezolizumab plus bevacizumab and chemotherapy as first-line metastatic nonsquamous non-small-cell lung cancer (nsqNSCLC) treatment, IMpower151 ( NCT04194203 ) trial was conducted in China to address regional differences. Chemotherapy-naive patients with nsqNSCLC (N = 305) were randomized 1:1 receive either atezolizumab, bevacizumab, carboplatin paclitaxel or pemetrexed (ABCPem/Pac; n 152) placebo (BCPem/Pac; 153). The primary endpoint investigator-assessed...
Introduction: Antithyroid drugs are widely used in the treatment of Graves' disease (GD), but relapse rate is very high after therapy withdrawal. We evaluated reduction effects intrathyroid injection dexamethasone (IID) on hyperthyroidism patients with newly diagnosed GD. Patients and Methods: A total 191 GD completed study. After 6 months methimazole (MMI), were randomly assigned to receive either MMI (96 patients) alone or combined IID (MMI+IID; 95 for 3 months, followed by continuing a...
Preeclampsia remains a major cause of maternal mortality and morbidity worldwide. It is generally accepted that the development placenta, including spiral artery remodelling, normal trophoblast cells function maternal‑fetal inflammation‑immune interactions, critical for pathogenesis preeclampsia. Several investigations have demonstrated microRNAs (miRNAs/miRs) in placenta may be potential molecular markers diagnosis In current study, aim was to investigate expression miR‑144‑3p patients with...
The current prognostic models for mortality and functional outcome after intracerebral hemorrhage (ICH) are not simple enough. To predict the of ICH, a new model, ICH index (ICHI), was established evaluated in this study.Medical records all cases with our hospital from January 2008 to August 2009 were reviewed. Multiple linear regression analyses used assess contributions independent variables ICH.Age, serum glucose, white blood cell counts (WBC), Glasgow Coma Scale (GCS) score found be...
This study examines the effect and mechanism of action Netrin-1 on bone marrow mesenchymal stem cells in angiogenesis. Tube formation migration were observed cell culture. Bone or Netrin-1–bone injected into ischaemic area rat hind limb first day after surgery. Laser Doppler perfusion imaging was performed to analyse levels vascular endothelial growth factor plasma muscles, immunohistochemistry immunofluorescence used medium containing markedly increased number tubes formed compared with...
e16170 Background: A phase II clinical study was conducted to evaluate the safety and efficacy of toripalimab, a novel PD-1 inhibitor, combined with chemotherapy in patients advanced biliary tract cancers (aBTCs) (NCT03796429). The preliminary results indicated combination treatment is well tolerable effective. Methods: Treatment naive aBTCs received toripalimab (240mg intravenously every three weeks) (gemcitabine 1000 mg/m2 d1, d8 + S-1 40-60mg bid D1-14, Q21d). continued until disease...
Abstract Evidence on the association between maternal Hb concentration and preterm birth (PTB) risk is inconclusive. This paper aimed to explore whether women with anaemia or high level before pregnancy would be at higher of PTB. We conducted a population-based cohort study 2 722 274 aged 20–49 years, who participated in National Free Pre-Pregnancy Checkups Project 2013 2015 delivered singleton 2016 rural China. Logistic models were used estimate OR 95 % CI after adjusting for confounding...
Abstract Background It is well known that second-trimester maternal serum alpha-fetoprotein (MS-AFP) a predictor for adverse pregnancy outcomes (APOs), such as preterm birth, stillbirth, preeclampsia and small gestational age (SGA). However, it unknown whether first-trimester MS-AFP also predictive of APOs. Methods We retrospectively reviewed the data on levels 3325 singleton pregnant women. The cutoff value 2.5 multiple median (MoM) was used to evaluate risks APOs regarding MS-AFP. receiver...
Abstract The placenta is the principal organ regulating respiratory, nutritional, endocrine and metabolic functions on behalf of developing fetus. Changes in gene expression patterns placenta-specific genes may influence fetal growth. We profiled 17 related to functioning term placentas (n=677) identify differentially expressed across birth weight categories [small (SGA), appropriate (AGA) large (LGA) for gestational age]. ABCG2, CEBPB, CRH, GCM1, GPC3, INSL4, PGF PLAC1 were inversely...
Abstract Background Frailty has been considered to be associated with major mortality and increased length of stay after cardiac surgery. This study aimed explore the predictive potential frailty assessment in prognosis elderly patients undergoing bypass Methods assessed preoperative according Fried’s phenotype, included 150 frail non-frail (≥ 65 y) who underwent The present evaluated based on sequential organ failure (SOFA) score, collected clinical indicators construct logistic regression...