A5070872244- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Chemokine receptors and signaling
- Gene Regulatory Network Analysis
- RNA and protein synthesis mechanisms
- Genetic Associations and Epidemiology
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Pancreatic and Hepatic Oncology Research
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- Multiple and Secondary Primary Cancers
- Proteoglycans and glycosaminoglycans research
- Bioinformatics and Genomic Networks
- Cancer Risks and Factors
- Inhalation and Respiratory Drug Delivery
- Pancreatitis Pathology and Treatment
- Reproductive System and Pregnancy
- Brain Metastases and Treatment
- IL-33, ST2, and ILC Pathways
- S100 Proteins and Annexins
- Fungal and yeast genetics research
Wellcome Sanger Institute
2023-2025
Spanish National Cancer Research Centre
2017-2024
Centro de Investigación del Cáncer
2021
Universitat de València
2016
Abstract The relationship between the human placenta—the extraembryonic organ made by fetus, and decidua—the mucosal layer of uterus, is essential to nurture protect fetus during pregnancy. Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate decidua, transforming maternal arteries into high-conductance vessels 1 . Defects in invasion arterial transformation established early pregnancy underlie common disorders such as pre-eclampsia 2 Here we have generated a...
Significance Pancreatic ductal adenocarcinoma is one of the most malignant human tumors for which there are no efficacious therapeutic strategies. This tumor type characterized by an abundant desmoplastic stroma that promotes progression. Yet recent studies have shown physical or genetic elimination leads to more aggressive development. Here, we decided reprogram stromal tissue identifying and subsequently targeting genes responsible their protumorigenic properties. Comparative transcriptome...
Abstract Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and associated toxicity have questioned clinical impact of this approach emphasized need alternative treatments. Given limited therapeutic options available these poor understanding molecular mechanisms underlying resistance metastatic lesions to WBRT, we sought uncover actionable targets biomarkers that could help refine patient...
Large-sequencing cancer genome projects have shown that tumors thousands of molecular alterations and their frequency is highly heterogeneous. In such scenarios, physicians oncologists routinely face lists genomic where only a minority them are relevant biomarkers to drive clinical decision-making. For this reason, the medical community agrees on urgent need methodologies establish relevance tumor alterations, assisting in profile interpretation, and, more importantly, prioritize those could...
Rank signaling enhances stemness in mouse and human mammary epithelial cells (MECs) mediates tumor initiation. Mammary tumors initiated by oncogenes or carcinogen exposure display high levels of pathway inhibitors have emerged as a new strategy for breast cancer prevention treatment. Here, we show that ectopic expression the epithelia unexpectedly delays onset reduces incidence oncogene-driven Neu PyMT models. Mechanistically, found to Rankl induces senescence, even absence other oncogenic...
Cell-cell communication is essential for tissue development, regeneration and function, its disruption can lead to diseases developmental abnormalities. The revolution of single-cell genomics technologies offers unprecedented insights into cellular identities, opening new avenues resolve the intricate interactions present in niches. CellPhoneDB a bioinformatics toolkit designed infer cell-cell by combining curated repository bona fide ligand-receptor with set computational statistical...
Gene expression has been investigated in relation with growth rate the yeast Saccharomyces cerevisiae, following different experimental strategies. The of some specific gene functional categories increases or decreases rate. Our recently published results have unveiled that these changes mRNA concentration depend on relative alteration synthesis and decay, that, addition to this gene-specific transcriptomic signature growth, global turnover We discuss here other previous concurrent...
Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into molecular mechanisms of these diseases. Nevertheless, data from different cohorts stored independently in public repositories a unified resource is imperative to assist researchers this field.Here, we present Diseases Explorer ( https://adex.genyo.es ), database that integrates 82 curated transcriptomics...
Atopic dermatitis (AD) is a multi-factorial skin disease with complex inflammatory signature including type 2 and 17 activation. Although colonization by S. aureus common in AD, the mechanisms rendering an organism prone to dysbiosis, role of IL-17A control aureus-induced inflammation, are not well understood. Here, we show several pathological aspects 2/type immune responses, elevated IgE, barrier dysfunction, pruritus, importantly, spontaneous JunBΔep mice, large transcriptomic overlap AD....
Abstract Motivation Drug immunomodulation modifies the response of immune system and can be therapeutically exploited in pathologies such as cancer autoimmune diseases. Results DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. provides significant immunomodulatory drugs targeting up to 70 cells subtypes through curated database that integrates 4960 profiles ∼2600 gene expression signatures. The tool also suggests potential...
In lung cancer immunotherapy, biomarkers to guide clinical decisions are limited. We now explore whether the detailed immunophenotyping of circulating peripheral blood mononuclear cells (PBMCs) can predict efficacy anti-PD-1 immunotherapy in patients with advanced non-small-cell (NSCLC). determined 107 PBMCs subpopulations a prospective cohort NSCLC before starting single-agent (study group), analyzed by flow cytometry. As control group, we studied malignancies initiating non-immunotherapy...
Abstract Chronic lymphocytic leukaemia is the most prevalent in Western countries. It an incurable disease characterized by a highly variable clinical course. ideal model for studying clonal heterogeneity and dynamics during cancer progression, response to therapy and/or relapse because usually develops over several years. Here we report analysis deep sequencing of sequential samples taken at different times from affected organs two patients with 12- 7-year courses, respectively. One...
Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into molecular mechanisms of these diseases. Nevertheless, data from different cohorts stored independently in public repositories a unified resource is imperative to assist researchers this field. Here, we present ADEx (https://adex.genyo.es), database that integrates 82 curated transcriptomics methylation...
Abstract Motivation Drug immunomodulation modifies the response of immune system and can be therapeutically exploited in pathologies such as cancer autoimmune diseases. Results DREIMT is a new hypothesis-generation web tool which performs drug prioritization analysis for immunomodulation. provides significant immunomodulatory drugs targeting up to 70 cells subtypes through curated database that integrates 4,960 profiles ~2,6K gene expression signatures. The also suggests potential...