María-Jesús Artiga
A5002299297- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- COVID-19 and Mental Health
- Viral-associated cancers and disorders
- interferon and immune responses
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
- Migration, Health and Trauma
- Glioma Diagnosis and Treatment
- Ethics in Clinical Research
- Cutaneous lymphoproliferative disorders research
- Biomedical Ethics and Regulation
- PARP inhibition in cancer therapy
- Acute Lymphoblastic Leukemia research
- S100 Proteins and Annexins
- Endoplasmic Reticulum Stress and Disease
- T-cell and Retrovirus Studies
Spanish National Cancer Research Centre
2002-2025
Centro de Investigación del Cáncer
2022-2025
Cancer Research Center
2024
Centro Nacional de Investigaciones Científicas
2009-2023
Bank of Spain
2013
Centro Nacional de Epidemiología
2004
Abstract Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and associated toxicity have questioned clinical impact of this approach emphasized need alternative treatments. Given limited therapeutic options available these poor understanding molecular mechanisms underlying resistance metastatic lesions to WBRT, we sought uncover actionable targets biomarkers that could help refine patient...
A high percentage of patients with brain metastases frequently develop neurocognitive symptoms; however, understanding how metastasis co-opts the function neuronal circuits beyond a tumor mass effect remains unknown. We report comprehensive multidimensional modeling functional analyses in context metastasis. By testing different preclinical models from various primary sources and oncogenic profiles, we dissociated heterogeneous impact on local field potential oscillatory activity cortical...
Abstract The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed COVID-19 the SCOURGE study, we found 133 cases (1.42%) detectable clonal mosaicism for chromosome alterations (mCA) 226 (5.08%) acquired loss Y (LOY). Individuals mosaic events (mCA and/or LOY) showed a 54% increase risk...
Abstract Current treatments of sporadic Burkitt's lymphoma (sBL) are associated with severe toxicities. A better understanding sBL formation would facilitate development less toxic therapies. The etiology remains, however, largely unknown, C-MYC up-regulation being the only lesion known to occur in all cases. Several studies examining role pathogenesis BL have concluded that translocation is not critical event and additional unidentified factors expected be involved this tumor. We herein...
The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, selection may contribute its distribution. Haplogroup H, the most abundant Europe, improved survival sepsis. Here we developed a random forest trained model for haplogroup calling using data procured from GWAS arrays. Our results reveal context SARS-CoV-2 pandemic, HV branch were found represent...
The purpose of this study is to analyze the effect two genetic polymorphisms, ACTN3 R577X, and ACE I/D, on physical condition in a sample active older women after two-year training period. was composed 300 healthy over age 60 who underwent program. Adapted tests from Senior Fitness Test were used. genotyping polymorphisms obtained participants’ DNA via buccal swabs. analysis polymorphism did not reveal differences between genotypes. R577X showed favorable for XX genotype leg strength (p:...
The genetic basis of severe COVID-19 has been thoroughly studied and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted largest GWAS meta-analysis for hospitalization admixed Americans, comprising a total 4,702 hospitalized cases recruited by other seven participating studies Host Genetic Initiative. We...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a genome-wide association (GWAS) for hospitalization admixed Americans, comprising total 4702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a GWAS for hospitalization admixed Americans, comprising total 4,702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We identified four genome-wide...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a genome-wide association (GWAS) for hospitalization admixed Americans, comprising total 4702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We...
Supplementary Methods, Legends for Figures 1-9 from <i>E2F1</i> Expression Is Deregulated and Plays an Oncogenic Role in Sporadic Burkitt's Lymphoma