Silvia Diz‐de Almeida
A5032528736- Liver Disease Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Migration, Health and Trauma
- PARP inhibition in cancer therapy
- Animal Virus Infections Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- Genetics and Neurodevelopmental Disorders
- Metabolomics and Mass Spectrometry Studies
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Ion channel regulation and function
- Williams Syndrome Research
- Endoplasmic Reticulum Stress and Disease
- Oral microbiology and periodontitis research
- Obsessive-Compulsive Spectrum Disorders
- Epigenetics and DNA Methylation
- RNA modifications and cancer
Centro de Investigación Biomédica en Red
2023-2025
Universidade de Santiago de Compostela
2022-2025
Instituto de Investigación de Enfermedades Raras
2023-2025
Centre for Biomedical Network Research on Rare Diseases
2023-2025
Instituto de Salud Carlos III
2023-2025
Tecnológico de Monterrey
2025
Center for Research in Molecular Medicine and Chronic Diseases
2022-2024
ERN GUARD-Heart
2024
The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, selection may contribute its distribution. Haplogroup H, the most abundant Europe, improved survival sepsis. Here we developed a random forest trained model for haplogroup calling using data procured from GWAS arrays. Our results reveal context SARS-CoV-2 pandemic, HV branch were found represent...
Pre-existing coronary artery disease (CAD), and thrombotic, inflammatory, or virus infectivity response phenomena have been associated with COVID-19 severity. However, the association of candidate single nucleotide variants (SNVs) related to mechanisms complications has seldom analysed. Our aim was test validate effect SNVs on CARGENCORS (CARdiovascular GENetic risk score for Risk Stratification patients positive SARS-CoV-2 [COVID-19] virus) is an age- sex-matched case-control study 818...
Despite the high contagion and mortality rates that have accompanied coronavirus disease-19 (COVID-19) pandemic, clinical presentation of syndrome varies greatly from one individual to another. Potential host factors accompany greater risk COVID-19 been sought schizophrenia (SCZ) patients seem present more severe than control counterparts, with certain gene expression similarities between psychiatric reported. We used summary statistics last SCZ, bipolar disorder (BD), depression (DEP)...
Introduction: Small Cell Lung cancer (SCLC) comprises 10-15% of all lung cases and is the most aggressive histological type. Survival poor molecular landscape this disease extraordinarily complex. The objective paper was to perform a Genome Wide Association Study (GWAS) using case-control study specifically designed for Cancer (SCLC). Methods: Incident were consecutively recruited from 8 hospitals different regions Spain. Controls same frequency sampling based on age sex distribution cases....
Abstract Aim Few genome‐wide association studies (GWAS) have been conducted for severe forms of periodontitis (stage III/IV grade C), and the number known risk genes is scarce. To identify further genetic variants to improve understanding disease aetiology, a GWAS meta‐analysis in cases with diagnosis at ≤35 years age was performed. Materials Methods Genotypes from German, Dutch Spanish III/IV‐C diagnosed ≤ 35 were imputed using TopMed. After quality control, on 8,666,460 1306 7817 controls...
The study of Obsessive-Compulsive Disorder (OCD) genomics has primarily been tackled by Genome-wide association studies (GWAS), which have encountered troubles in identifying replicable single nucleotide polymorphisms (SNPs). Endophenotypes emerged as a promising avenue trying to elucidate the genomic bases complex traits such OCD.We analyzed SNPs across whole genome with construction visuospatial information and executive performance through four neurocognitive variables assessed...
The genetic basis of severe COVID-19 has been thoroughly studied and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted largest GWAS meta-analysis for hospitalization admixed Americans, comprising a total 4,702 hospitalized cases recruited by other seven participating studies Host Genetic Initiative. We...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a genome-wide association (GWAS) for hospitalization admixed Americans, comprising total 4702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a GWAS for hospitalization admixed Americans, comprising total 4,702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We identified four genome-wide...
The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a genome-wide association (GWAS) for hospitalization admixed Americans, comprising total 4702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We...
Abstract The genetic basis of severe COVID-19 has been thoroughly studied, and many risk factors shared between populations have identified. However, reduced sample sizes from non-European groups limited the discovery population-specific common loci. In this second study nested in SCOURGE consortium, we conducted a GWAS for hospitalization admixed Americans, comprising total 4,702 hospitalized cases recruited by seven other participating studies Host Genetic Initiative. We identified four...