Lucía Boix-Palop
A5111365138- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Enterobacteriaceae and Cronobacter Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Genetic Associations and Epidemiology
- COVID-19 and Mental Health
- Mycobacterium research and diagnosis
- Cardiac pacing and defibrillation studies
- interferon and immune responses
- Patient Satisfaction in Healthcare
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Clostridium difficile and Clostridium perfringens research
- Escherichia coli research studies
Mútua Terrassa
2016-2025
University Hospital Mútua de Terrassa
2020-2025
Universitat Internacional de Catalunya
2016-2024
Universitat de Barcelona
2021-2023
Dartmouth College
2020
Institut d'Investigació Biomédica de Bellvitge
2013
Bellvitge University Hospital
2013
Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study (NCT02655419; EudraCT 2015-002726-39) enrolled adults cIAI into sequential cohorts for 5–14 days treatment. Cohort 1 received an loading dose 500/137 mg (30 min infusion),...
<h3>Importance</h3> The consumption of broad-spectrum drugs has increased as a consequence the spread multidrug-resistant (MDR)<i>Escherichia coli</i>. Finding alternatives for these infections is critical, which some neglected may be an option. <h3>Objective</h3> To determine whether fosfomycin noninferior to ceftriaxone or meropenem in targeted treatment bacteremic urinary tract (bUTIs) due MDR<i>E <h3>Design, Setting, and Participants</h3> This multicenter, randomized, pragmatic, open...
Infective endocarditis (IE) has high mortality and morbidity requires long hospital stays to deliver the antibiotic treatment recommended in clinical practice guidelines. The objectives were analyze health outcomes of use dalbavancin (DBV) consolidation IEs caused by Gram-positive cocci (GPC) perform a pharmacoeconomic study. This observational, retrospective, Spanish multicenter study patients with IE who received DBV as part phase followed for at least 12 months. was approved Provincial...
BackgroundEscherichia coli is the most frequent cause of bloodstream infections (BSIs). About one-third patients with BSIs due to E develop sepsis or shock. The objective this study characterise microbiological features blood isolates causing septic shock provide exploratory information for future diagnostic, preventive, therapeutic interventions.MethodsE from a multicentre cross-sectional older than 14 years presenting (according Third International Consensus Definitions Sepsis and Septic...
Patients with infective endocarditis (IE) frequently have cardiac implantable electronic devices (CIEDs). Here, we aim to define the clinical profile and prognostic factors of IE in these patients.Infective cases were prospectively identified Spanish National Endocarditis Registry. From 3996 IE, 708 (17.7%) had a CIED 424 CIED-related (lead vegetation). older (68 ± 11 vs. 73 8 years); more comorbidities {pulmonary disease [176 (24.8%) 545 (16.7%)], renal [239 (33.8%) 740 (22.7%)], diabetes...
Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than alone hospitalized adults MSSA conducted a multicenter, open-label, phase III-IV superiority randomized clinical trial. randomly assigned (1:1) to receive 2 g intravenous every 4 h or 3 6 for the initial 7 days. The primary endpoint was at day 7, composite following criteria: patient...
Abstract The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed COVID-19 the SCOURGE study, we found 133 cases (1.42%) detectable clonal mosaicism for chromosome alterations (mCA) 226 (5.08%) acquired loss Y (LOY). Individuals mosaic events (mCA and/or LOY) showed a 54% increase risk...
Background. Infective endocarditis (IE) is a severe condition. Our aim was to describe the profile and prognosis of patients with multivalvular infective (MIE) compare them single-valve IE (SIE). Methods. We used retrospective analysis Spanish Registry (2008−2020). Results. From 4064 definite cases valvular IE, 577 (14.2%) had MIE. In MIE, most common locations were mitral (552, 95.7%) aortic (550, 95.3%), mitral-aortic involvement present in 507 (87.9%). The etiologies S. viridans (192,...
The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, selection may contribute its distribution. Haplogroup H, the most abundant Europe, improved survival sepsis. Here we developed a random forest trained model for haplogroup calling using data procured from GWAS arrays. Our results reveal context SARS-CoV-2 pandemic, HV branch were found represent...
Background/Objectives: The COVID-19 pandemic resulted in 675 million cases and 6.9 deaths by 2022. Despite substantial declines case fatalities following widespread vaccination campaigns, the threat of future coronavirus outbreaks remains a concern. Current treatments for have been repurposed from existing therapies other infectious non-infectious diseases. Emerging evidence suggests role genetic factors both susceptibility to SARS-CoV-2 infection response treatment. However, comprehensive...
Abstract Aim Prolonged antibiotic treatments contribute to increasing antimicrobial resistance. Current guidelines recommend 5–7 days of treatment in patients with surgical infection an adequate source control. Antibiotic stewardship aim optimize the use antibiotics, including their duration. The 7VINCut nationwide intervention aims reduce duration &lt;7 patients. Methods Prospective cohort study conducted 37 hospitals 2019–2022. Patients admitted services &gt;7 were analysed. teams...
The POET trial demonstrated that moving from intravenous to oral antibiotics in stable patients with left-sided infective endocarditis (IE) was noninferior fully parenteral treatment. However, it did not compare outpatient strategies. OraPAT-IE GAMES is a noninferiority, multicenter, randomized, open-label study aimed partial versus antibiotic therapy (OPAT) for consolidation of treatment IE. A total 342 IE caused by selected micro-organisms will eventually be included. After minimum 10 days...
Abstract Background/Objectives To assess the microbiological and clinical features of Klebsiella pneumoniae healthcare-associated bacteraemia urinary origin (HCA-BUO) in Spain, with a particular focus on third generation cephalosporin-(3GCR-Kp) carbapenem-resistant (CR-Kp) isolates. Methods A total 96 (21.4%, 96/449) K. blood isolates were prospectively collected from patients HCA-BUO (n=443) 12 tertiary-care hospitals Spain (2017-2019). Antimicrobial susceptibility was determined (standard...
We investigated the effectiveness of early oral switch for treating Enterobacterales bloodstream infection (BSI) by performing a post hoc emulation trial SIMPLIFY trial. conducted analysis randomised controlled specified target characteristics selecting patients who achieved clinical stability on day 5. categorised into those switched 5 and continued intravenously. The primary outcome was cure at test cure. set propensity score being to reduce confounding. ran simple,...
Cerebrovascular complications are frequent in pneumococcal meningitis and associated with poor functional outcomes. Among these complications, the incidence of cerebral vasculitis (CV) has been increasingly reported, but neither its pathogenesis nor relationship cortisone treatment have conclusively established. We wanted to describe cerebrospinal fluid (CSF) metalloprotease (MMP) levels, which linked damage (MMP-2, MMP-9, antagonist TIMP-1), differences microbiological serotypes or...
Abstract Background Catheter-related bloodstream infections (CRBSIs) increase morbidity and mortality, prolong hospitalization generate considerable medical costs. Recent guidelines for CRBSI recommend empirical therapy against Gram-positive bacteria (GPB) restrict coverage Gram-negative (GNB) only to specific circumstances. Objectives To investigate predictors of GNB aetiology in assess the outcome patients with CRBSI. Methods Patients were selected from PROBAC cohort, a prospective,...
Guidelines recommend 5-7 days of antibiotic treatment in patients with surgical infection and adequate source control. This nationwide stewardship intervention aimed to reduce the duration treatments <7 days.Prospective cohort study evaluating receiving antibiotics ≥7 32 hospitals. Indication for treatment, quality control, type recommendations issued, adherence were analysed. Temporal trends percentages >7 evaluated using a linear regression model Pearson's correlation coefficients.A total...