A5080609002- Inflammatory Bowel Disease
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Urinary Tract Infections Management
- Biosimilars and Bioanalytical Methods
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Hidradenitis Suppurativa and Treatments
- Antifungal resistance and susceptibility
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal and Anal Carcinomas
- Asthma and respiratory diseases
- Renal Transplantation Outcomes and Treatments
- Pharmaceutical Economics and Policy
- Antimicrobial agents and applications
- Escherichia coli research studies
- Tuberculosis Research and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Advancements in Transdermal Drug Delivery
- Lipid Membrane Structure and Behavior
- Vascular Tumors and Angiosarcomas
- Bacterial Identification and Susceptibility Testing
- Chemotherapy-related skin toxicity
Hospital Universitario Virgen Macarena
2014-2025
Universidad de Sevilla
2019-2025
GlaxoSmithKline (India)
2022
AstraZeneca (Brazil)
2022
Sanofi (France)
2022
Hospital Universitario La Paz
2020
<h3>Importance</h3> The consumption of broad-spectrum drugs has increased as a consequence the spread multidrug-resistant (MDR)<i>Escherichia coli</i>. Finding alternatives for these infections is critical, which some neglected may be an option. <h3>Objective</h3> To determine whether fosfomycin noninferior to ceftriaxone or meropenem in targeted treatment bacteremic urinary tract (bUTIs) due MDR<i>E <h3>Design, Setting, and Participants</h3> This multicenter, randomized, pragmatic, open...
Cefepime is an antibiotic with a broad spectrum of antimicrobial activity. However, this has several side effects and high degradation rate. For reason, the preparation characterization new liposomes that are able to encapsulate seem be important research line in pharmaceutical industry. Anionic cationic were prepared characterized. All structures contained same surfactant, N,N,N-triethyl-N-(12-naphthoxydodecyl)ammonium. Results showed better encapsulation-efficiency percentage (EE%)...
The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment inflammatory bowel disease (IBD). aim was analyze association between these variants long-term drugs pediatric IBD. We performed an observational, multicenter, ambispective study which we selected 340 IBD patients under 18 years of age diagnosed treated from a network Spanish hospitals. Genotypes failure were analyzed using Kaplan-Meier curves Cox logistic regression....
Changes in gene expression profiles among individuals with inflammatory bowel diseases (IBDs) could potentially influence the responsiveness to anti-TNF treatment. The aim of this study was identify genes that serve as predictors early response therapies pediatric IBD patients prior initiation
The rise of biologic agents has been a major breakthrough in treating immune-mediated inflammatory diseases (IMIDs). However, their high cost underscores the need for strategies to optimize treatment efficiency. Biosimilars offer cost-effective alternatives biologics. This study aimed assess biosimilar drug availability's impact on therapy access IMIDs.
Around a 20–30% of inflammatory bowel disease (IBD) patients are diagnosed before they 18 years old. Anti-TNF drugs can induce and maintain remission in IBD, however, up to 30% do not respond. The aim the work was identify markers that would predict an early response anti-TNF pediatric with IBD. study population included 43 aged <18 IBD who started treatment infliximab or adalimumab. Patients were classified into primary responders (n = 27) non-responders therapy 6). Response could be...
Background: Up to 30% of patients with pediatric inflammatory bowel disease (IBD) do not respond anti-Tumor Necrosis Factor (anti-TNF) therapy. The aim this study was identify pharmacogenomic markers that predict early response anti-TNF drugs in IBD. Methods: An observational, longitudinal, prospective cohort conducted. population comprised 38 IBD aged < 18 years who started treatment infliximab or adalimumab (29 responders and nine non-responders). Whole gene expression profiles from...
Therapeutic drug monitoring of infliximab levels in patients with inflammatory bowel disease (IBD) optimizes patients' treatment. The reference technique is based on enzyme-linked immunosorbent assay (ELISA) although point care (POC) assays are being developed. To assess the performance a new rapid immunochromatographic POC (Promonitor Quick IFX) compared ELISA to measure IBD. A prospective, observational, unicentric study was performed capillary blood samples from IBD before infusion...
ABSTRACT Objectives: Inflammatory bowel disease (IBD) is more complex in children and they will have to live with the for much longer. For this reason, it necessary optimize treatment. The polymorphisms associated response anti‐tumor necrosis factor (TNF) drugs adults IBD not been analyzed children. aim of study was identify genetic variants long‐term anti‐TNF IBD. Methods: An observational, longitudinal, ambispective cohort's conducted. We recruited 209 anti‐TNF‐treated diagnosed genotyped...
Abstract We describe a case of one patient with cystic fibrosis who developed pan‐resistant Burkholderia cepacia complex rapidly progressive bacteraemic pneunonia, following bilateral lung transplantation. The was treated targeted combination antibiotic therapy (meropenem plus ceftazidime/avibactam high doses nebulized colistimethate sodium). Evolution the disease complicated by multiple organ system dysfunction. Finally, clinical improvement and microbiological cure achieved.
Aims Identifying DNA variants associated with trough serum anti‐tumour necrosis factor (TNF) levels could predict response to treatment in inflammatory bowel disease (IBD). To date, no specific studies have been performed children. The aim of this study was identify genetic anti‐TNF and whether these are differential markers for infliximab adalimumab. Methods We included 154 children (age < 18 years) from 17 hospitals who had diagnosed IBD actively treated or Twenty‐one polymorphisms were...
Pseudoxanthoma elasticum (PXE) is characterized by low levels of inorganic pyrophosphate (PPi) and a high activity tissue-nonspecific alkaline phosphatase (TNAP). Lansoprazole partial inhibitor TNAP. The aim was to investigate whether lansoprazole increases plasma PPi in subjects with PXE. We conducted 2 × randomized, double-blind, placebo-controlled crossover trial patients Patients were allocated 30 mg/day or placebo two sequences 8 weeks. primary outcome the differences between phases. 29...
Objective The study aimed to reach a consensus on the most relevant patient-reported outcomes (PROs), corresponding measures (PROMs), and measurement frequency during severe asthma patient follow-up.
The goal of this work is to investigate if the synergistic antifungal activity between cyclosporine A, CsA, and voriconazole, VRZ, increases when both drugs are encapsulated in a nanocarrier as compared they free. preparation characterization blank VRZ CsA loaded polymeric based PLGA nanoparticles (PLGA, PLGA-PEG, PLGA+PEG) was necessary previous step. Using more suitable NPs, those PLGA, susceptibility tests performed with VRZ-loaded show no significant increase comparison that free VRZ....
Background: Ustekinumab (UST) is an effective treatment option in Crohn’s disease (CD) and ulcerative colitis (UC). However, it still remains unclear if therapeutic drug monitoring could be helpful to guide clinicians. Objectives: The aim of our study was analyze the relationship between UST through levels (UST TL ) clinical outcomes real-world inflammatory bowel (IBD) patients. Design: We performed a unicentric retrospective including patients with IBD under at least one level...
Pediatric patients present changing physiological features. Because of the lack land suitable for commercial management, pediatric specialties very often need to prepare extemporaneous formulations improve dosage and administration drugs children. Oral liquid are most patients. Clonidine is widely used in population opioid withdrawal, hypertensive crisis, attention deficit disorders hyperactivity syndrome, as an analgesic neuropathic cancer pain. The objective was study physicochemical...
Infant hemangioma (IH) is the most common tumor in infants, which affects 5-10% of white children. It a vascular origin that appears first months life. The indication for treatment IH not approved datasheet product, however it has been used infant by topical administration as an alternative to oral propranolol, avoiding main problems route (bradycardia and hypotension). objective this work study physical chemical (HPLC stability indicating method) 0.5% timolol gel application during 60 days...
This study analyzes the pharmacokinetic variability of piperacillin in non-critically ill patients with Enterobacteriaceae bloodstream infections (EBSI) and explores predicted clinical outcomes piperacillin-related neurotoxicity under different renal conditions. Hospitalized, treated piperacillin–tazobactam for EBSI were included. Four serum samples per patient collected analyzed. A population model was developed using Pmetrics package R. Monte Carlo simulations various dosage regimens 4 g...