Carmen Ardanuy

ORCID: 0000-0003-0225-607X
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About
Contact & Profiles
Research Areas
  • Pneumonia and Respiratory Infections
  • Bacterial Infections and Vaccines
  • Antimicrobial Resistance in Staphylococcus
  • Streptococcal Infections and Treatments
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Respiratory viral infections research
  • Infective Endocarditis Diagnosis and Management
  • Antibiotic Resistance in Bacteria
  • Bacterial Identification and Susceptibility Testing
  • Antibiotics Pharmacokinetics and Efficacy
  • Microbial infections and disease research
  • Respiratory and Cough-Related Research
  • Influenza Virus Research Studies
  • Neutropenia and Cancer Infections
  • Nosocomial Infections in ICU
  • Bacterial biofilms and quorum sensing
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Otolaryngology and Infectious Diseases
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Inhalation and Respiratory Drug Delivery
  • Pediatric health and respiratory diseases
  • Antibiotic Use and Resistance
  • Tuberculosis Research and Epidemiology
  • Long-Term Effects of COVID-19

Universitat de Barcelona
2016-2025

Institut d'Investigació Biomédica de Bellvitge
2016-2025

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025

Instituto de Salud Carlos III
2016-2025

Bellvitge University Hospital
2016-2025

Centro de Investigación Biomédica en Red
2011-2025

Centre for Biomedical Network Research on Rare Diseases
2011-2024

Hospital Universitario Virgen de las Nieves
2024

Universidad Rey Juan Carlos
2024

Duran i Reynals Hospital
2023-2024

The aim of this study was to characterize the first two extended-spectrum cephalosporin-resistant and multidrug-resistant (MDR) Neisseria gonorrhoeae isolates collected from sexually related patients (men who have sex with men) in Spain. Antimicrobial susceptibility studied by Etest. Genes involved quinolone, ceftriaxone multidrug resistance were amplified PCR sequenced both directions. typed N. multi-antigen sequence typing (NG-MAST). had same MDR profile, showing penicillin (MIC 0.094...

10.1093/jac/dks162 article EN Journal of Antimicrobial Chemotherapy 2012-05-07

Gram-negative microorganisms are a significant cause of infection in both community and nosocomial settings. The increase, emergence, spread antimicrobial resistance among bacteria the most important health problems worldwide. One mechanisms used by is biofilm formation, which also mechanism virulence. This study analyzed possible relationship between formation isolates three species. Several relationships were found ability to form resistance, being different for each Indeed, gentamicin...

10.1089/mdr.2018.0027 article EN Microbial Drug Resistance 2018-08-24

Dynamic trends of invasive pneumococcal disease (IPD) including the evolution prevalent serotypes are very useful to evaluate impact current and future conjugate vaccines (PCVs) rise non-vaccine serotypes. In this study, we include epidemiological patterns S. pneumoniae before after COVID-19 pandemic.

10.1016/j.jinf.2024.106204 article EN cc-by Journal of Infection 2024-06-19

ABSTRACT An outbreak due to extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-KP) was detected from May 1993 June 1995. A total of 145 patients, particularly patients in intensive care units (ICUs) (107 [72%]), were colonized or infected. Infection developed 92 (63%) and primary bacteremia caused by ESBL-KP the most frequent infection (40 [43%]). single clone identified pulsed-field gel electrophoresis analysis throughout whole period, no molecular epidemiological...

10.1128/aac.42.1.53 article EN Antimicrobial Agents and Chemotherapy 1998-01-01

Background. A dramatic decrease in the incidence of invasive pneumococcal disease (IPD) was observed among children and adults United States after introduction 7-valent conjugate vaccine (PCV7). Little is known about IPD PCV7 licensure Europe. The objective this study to examine changes prevalence era. Methods. We undertook a prospective involving with who required hospital admission southern area Barcelona, Spain. Three periods were studied: pre-PCV7 period (1997–2001), early (2002–2004),...

10.1086/594125 article EN Clinical Infectious Diseases 2008-11-26

<h3>Background:</h3> Host- and pathogen-related factors associated with septic shock in pneumococcal pneumonia are not well defined. The aim of this study was to identify risk for ascertain patient outcomes. Serotypes, genotypes antibiotic resistance isolated strains were also analysed. <h3>Methods:</h3> Observational analysis a prospective cohort non-severely immunosuppressed hospitalised adults pneumonia. Septic defined as systolic blood pressure &lt;90 mm Hg peripheral hypoperfusion the...

10.1136/thx.2009.123612 article EN Thorax 2009-12-08

Introduction of pneumococcal conjugate vaccines (PCVs) has reduced the disease caused by vaccine serotypes in children, providing herd protection to adults. However, emergence nonvaccine is great concern worldwide.This study includes national laboratory data from invasive (IPD) cases that affected pediatric and adult populations during 2009-2019. The impact implementing different strategies for immunocompetent adults comparing Spanish regions used 13-valent PCV (PCV13) vs 23-valent...

10.1093/cid/ciaa1483 article EN Clinical Infectious Diseases 2020-09-28
Belén Gutiérrez‐Gutiérrez María Dolores del Toro Alberto M. Borobia Antonio J. Carcas Inmaculada Jarrín and 95 more María Yllescas Pablo Ryan Jerónimo Pachón Jordi Carratalà Juan Berenguer José Ramón Arribas Jesús Rodríguez‐Baño Esther Aznar Muñoz Pedro Gil Divasson Patricia González Muñiz Clara Aguirre Pilar Retamar Adoración Valiente Luis Eduardo López-Cortés Jesús Sojo-Dorado José María Bravo-Ferrer Elena Salamanca Zaira R. Palacios‐Baena Patricia Pérez‐Palacios M. Gandullo-Moro Rocío Ruíz-Hueso Natalia Moya-González Agustín Valido-Morales María Pavón-Masa Marta Díaz‐Menéndez Fernando Calle Marta Arsuaga Vicente Elena Trigo Esteban Rosa de Miguel Buckley Julen Cadiñanos Carmen Busca Rafael Micán Marta Mora-Rillo Belén Loeches Yagüe José Ignacio Bernardino Julio García‐Rodríguez Rocío Montejano Beatriz Díaz‐Pollán Juan Carlos López Margarita Ramírez-Schacke Isabel Gutiérrez Francisco Tejerina Teresa Aldámiz‐Echevarría Cristina Díez Chiara Fanciulli Leire Pérez‐Latorre F Parras Pilar Catalán María E. García-Leoni Isabel Pérez-Tamayo Luís Puente‐Maestu Jamil Cedeño A. Such-Díaz Elena Alba Álvaro-Alonso Elsa Izquierdo-García Juan Torres‐Macho Guillermo Cuevas Helena Notario B. Mestre-Gómez Eva Jiménez Inés Fernández-Jiménez Ana Josefa Tebar-Martínez Fátima Brañas Jorge Valencia Mario Pérez Marta Alvarado Gabriela Abelenda-Alonso Carmen Ardanuy Alba Bergas Guillermo Cuervo M.Á. Domínguez Miguel Fernández-Huerta Carlota Gudiol Laia Lorenzo-Esteller Jordí Niubó Sandra Pérez‐Recio Daniel Podzamczer Miquel Pujol Alexander Rombauts Núria Trullen José Miguel Cisneros Cristina Amodeo Pedro Camacho Núria Espinosa Manuel García‐Gutiérrez Luis Jara‐Palomares Rocío González-León José Molina Maria Martin María Paniagua Manuel Poyato Borrego Ángel Rodríguez-Villodres Zaida Ruiz de Azua Celia Salamanca Mo Antonia Sepúlveda Berrocal

10.1016/s1473-3099(21)00019-0 article EN other-oa The Lancet Infectious Diseases 2021-02-24
Jesús Sojo-Dorado Inmaculada López-Hernández Clara Rosso-Fernández Isabel Morales Zaira R. Palacios‐Baena and 76 more Alicia Hernández‐Torres Esperanza Merino Laura Escolà‐Vergé Elena Bereciartúa Elisa García‐Vázquez Vicente Pintado Lucía Boix-Palop Clara Natera-Kindelán Luisa Sorlí Núria Borrell Livia Giner Concha Amador-Prous Evelyn Shaw A Jover José Molina Rosa Martínez-Álvarez Carlos Dueñas Jorge Calvo Jose T. Silva Miguel Ángel Cárdenes María Lecuona Virginia Pomar Lucía Valiente de Santis Genoveva Yagüe‐Guirao María Ángeles Lobo-Acosta Vicente Merino‐Bohórquez Álvaro Pascual Jesús Rodríguez‐Baño Benito Almirante Mario Fernández José Ramón Paño‐Pardo Marina de Cueto Pilar Retamar Luis Eduardo López-Cortés Belén Gutiérrez‐Gutiérrez Fernando Docobo-Pérez Irene Borreguero Manuel Cameán Encarnación Moral‐Escudero Ana Pareja-Rodríguez de Vera María del Carmen Martínez-Toldos Ana Blázquez-Abellán Alba Bellés Bellés María Fernanda Ramírez-Hidalgo Beatriz Mirelis Esther Calbo Mariona Xercavins Irene Gracia-Ahufinger Angela M. Cano-Yuste Laura Guío Carrión José Luis Hernández-Davó Carlos Pigrau-Serrallach Belen Viñado-Pérez Mireia Puig Asensio Carmen Ardanuy Miquel Pujol Dácil García-Rosado Concepción Gil-Anguita Ana Siverio Adelina Gimeno Vicente Boix-Martínez Sergio Reus Iván Agea-Durán Carmen Fariñas Begoña Palop Helem Vílchez José Antonio Lepe María Victoria Gil-Navarro Rafael San Juan Fernando Cháves Rosa Escudero Francesca Gioia Ana María Sánchez‐Díaz Ana María Cañas-Pedrosa Nayra Sangil-Monroy Carla Toyas-Miazza

<h3>Importance</h3> The consumption of broad-spectrum drugs has increased as a consequence the spread multidrug-resistant (MDR)<i>Escherichia coli</i>. Finding alternatives for these infections is critical, which some neglected may be an option. <h3>Objective</h3> To determine whether fosfomycin noninferior to ceftriaxone or meropenem in targeted treatment bacteremic urinary tract (bUTIs) due MDR<i>E <h3>Design, Setting, and Participants</h3> This multicenter, randomized, pragmatic, open...

10.1001/jamanetworkopen.2021.37277 article EN cc-by-nc-nd JAMA Network Open 2022-01-13

Fecal colonization with multiresistant Acinetobacter baumannii was evaluated in 189 consecutive patients intensive care units (ICUs) during two different 2-month periods (October–November 1993 and May–June 1994). Rectal swabs were obtained weekly from admission to discharge the ICU. Overall, 77 (41%) had A. fecal colonization; detected 55(71%) of within first week their ICU stay. Clinical infections due occurred more frequently than those without (26% vs. S%, respectively; P < .001). The...

10.1093/clinids/23.2.329 article EN Clinical Infectious Diseases 1996-08-01

From March 1995 to 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 were treated sulbactam; of them, five excluded because they had received < or =48 h therapy. A total 42 patients, 27 males and 15 females a mean age 60+/-15 years, finally evaluated. Infections as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; pneumonia, 2....

10.1093/jac/42.6.793 article EN Journal of Antimicrobial Chemotherapy 1998-12-01

ABSTRACT The treatment of life-threatening infections due to carbapenem-resistant Acinetobacter baumannii has become a serious challenge for physicians worldwide. Often, only colistin shows in general good vitro activity against these strains, but its antibacterial efficacy comparison with the antibiotics most used clinical practice is not well known. We studied versus those imipenem, sulbactam, tobramycin, and rifampin an experimental pneumonia model immunocompetent mice. three strains A....

10.1128/aac.46.6.1946-1952.2002 article EN Antimicrobial Agents and Chemotherapy 2002-06-01

Multidrug-resistant Streptococcus pneumoniae isolates of serotype 19A have emerged all over the world in recent years. The aim this study was to characterize highly penicillin-resistant pneumococcal strains serotype, collected Spain from 1997 2007 patients with invasive disease. Antibiotic susceptibility studied by microdilution. All pneumococci were typed PFGE and selected multilocus sequence typing (MLST). presence genes related Tn916 family transposons investigated PCR. From a total 1197...

10.1093/jac/dkp210 article EN Journal of Antimicrobial Chemotherapy 2009-06-17

Current information regarding bloodstream infection (BSI) in patients with solid tumors is scarce. We assessed the epidemiology, antibiotic therapy, and outcomes of BSI these patients. also compared who died those survived to identify risk factors associated mortality. From January 2006 July 2012 all episodes at a cancer center were prospectively recorded analyzed. A total 528 documented 489 The most frequent neoplasms hepatobiliary (19%), followed by lung (18%) lower gastrointestinal...

10.1097/md.0000000000000026 article EN cc-by-nc Medicine 2014-05-01

Auranofin is an FDA-approved, gold-containing compound in clinical use for the oral treatment of rheumatoid arthritis and has been recently granted by regulatory authorities due to its antiprotozoal properties.A reprofiling strategy was performed with a Streptococcus pneumoniae phenotypic screen proprietary library compounds, consisting both FDA-approved unapproved bioactive compounds. Two different multiresistant S. strains were employed sepsis mouse model infection. In addition, MRSA...

10.1093/jac/dkv163 article EN Journal of Antimicrobial Chemotherapy 2015-07-04

The prevalence of a new hypervirulent and hypermucoviscous K. pneumoniae phenotype (Hmv) is increasing worldwide, mainly linked to serotypes K1 K2. Since capsular thickness can directly affect the capability form biofilms, we aimed evaluate association between Hmv with adhesion biofilm formation in collection clinical isolates. We selected 38 isolates [15 serotype K1; 9 K2; 3 non-K1/K2 (rmpA+); 11 (rmpA-)] 7 non-Hmv was assessed through mucoviscosity test. Serum resistance determined by...

10.1371/journal.pone.0222628 article EN cc-by PLoS ONE 2019-09-18

The increase in erythromycin resistance among Streptococcus pyogenes isolates is a cause for concern. We analysed trends macrolide resistance, phenotypes, genotypes, determinants and transposons erythromycin-resistant S. collected from adults Barcelona hospital (1993–2008). Antibiotic susceptibility was studied by microdilution. Molecular typing performed PFGE, emm multilocus sequence (MLST). Macrolide genes those related to the Tn916 family of were detected PCR. Ninety-nine (18.3%) 541...

10.1093/jac/dkq006 article EN Journal of Antimicrobial Chemotherapy 2010-01-29

ObjectivesTo determine the prevalence of smoking and alcohol abuse among patients with invasive pneumococcal disease (IPD) in order to promote prevention strategies.MethodsWe prospectively studied all culture-proven IPD cases aged ≥18 years during period 1997–2011. The habits were evaluated. Pneumococcal serotyping was performed.ResultsThere 1378 cases, a mean age 61 ± 17 years; 65% males. Compared general population 18–64 years, same group more often current smokers (57% vs. 35%, p < 0.001)...

10.1016/j.ijid.2013.12.013 article EN cc-by-nc-sa International Journal of Infectious Diseases 2014-05-19
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