A5050223354- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Microbial infections and disease research
- Respiratory and Cough-Related Research
- Influenza Virus Research Studies
- Neutropenia and Cancer Infections
- Nosocomial Infections in ICU
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Otolaryngology and Infectious Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Antibiotic Use and Resistance
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
Universitat de Barcelona
2016-2025
Institut d'Investigació Biomédica de Bellvitge
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2016-2025
Instituto de Salud Carlos III
2016-2025
Bellvitge University Hospital
2016-2025
Centro de Investigación Biomédica en Red
2011-2025
Centre for Biomedical Network Research on Rare Diseases
2011-2024
Hospital Universitario Virgen de las Nieves
2024
Universidad Rey Juan Carlos
2024
Duran i Reynals Hospital
2023-2024
The aim of this study was to characterize the first two extended-spectrum cephalosporin-resistant and multidrug-resistant (MDR) Neisseria gonorrhoeae isolates collected from sexually related patients (men who have sex with men) in Spain. Antimicrobial susceptibility studied by Etest. Genes involved quinolone, ceftriaxone multidrug resistance were amplified PCR sequenced both directions. typed N. multi-antigen sequence typing (NG-MAST). had same MDR profile, showing penicillin (MIC 0.094...
Gram-negative microorganisms are a significant cause of infection in both community and nosocomial settings. The increase, emergence, spread antimicrobial resistance among bacteria the most important health problems worldwide. One mechanisms used by is biofilm formation, which also mechanism virulence. This study analyzed possible relationship between formation isolates three species. Several relationships were found ability to form resistance, being different for each Indeed, gentamicin...
Dynamic trends of invasive pneumococcal disease (IPD) including the evolution prevalent serotypes are very useful to evaluate impact current and future conjugate vaccines (PCVs) rise non-vaccine serotypes. In this study, we include epidemiological patterns S. pneumoniae before after COVID-19 pandemic.
ABSTRACT An outbreak due to extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-KP) was detected from May 1993 June 1995. A total of 145 patients, particularly patients in intensive care units (ICUs) (107 [72%]), were colonized or infected. Infection developed 92 (63%) and primary bacteremia caused by ESBL-KP the most frequent infection (40 [43%]). single clone identified pulsed-field gel electrophoresis analysis throughout whole period, no molecular epidemiological...
Background. A dramatic decrease in the incidence of invasive pneumococcal disease (IPD) was observed among children and adults United States after introduction 7-valent conjugate vaccine (PCV7). Little is known about IPD PCV7 licensure Europe. The objective this study to examine changes prevalence era. Methods. We undertook a prospective involving with who required hospital admission southern area Barcelona, Spain. Three periods were studied: pre-PCV7 period (1997–2001), early (2002–2004),...
<h3>Background:</h3> Host- and pathogen-related factors associated with septic shock in pneumococcal pneumonia are not well defined. The aim of this study was to identify risk for ascertain patient outcomes. Serotypes, genotypes antibiotic resistance isolated strains were also analysed. <h3>Methods:</h3> Observational analysis a prospective cohort non-severely immunosuppressed hospitalised adults pneumonia. Septic defined as systolic blood pressure <90 mm Hg peripheral hypoperfusion the...
Introduction of pneumococcal conjugate vaccines (PCVs) has reduced the disease caused by vaccine serotypes in children, providing herd protection to adults. However, emergence nonvaccine is great concern worldwide.This study includes national laboratory data from invasive (IPD) cases that affected pediatric and adult populations during 2009-2019. The impact implementing different strategies for immunocompetent adults comparing Spanish regions used 13-valent PCV (PCV13) vs 23-valent...
<h3>Importance</h3> The consumption of broad-spectrum drugs has increased as a consequence the spread multidrug-resistant (MDR)<i>Escherichia coli</i>. Finding alternatives for these infections is critical, which some neglected may be an option. <h3>Objective</h3> To determine whether fosfomycin noninferior to ceftriaxone or meropenem in targeted treatment bacteremic urinary tract (bUTIs) due MDR<i>E <h3>Design, Setting, and Participants</h3> This multicenter, randomized, pragmatic, open...
Fecal colonization with multiresistant Acinetobacter baumannii was evaluated in 189 consecutive patients intensive care units (ICUs) during two different 2-month periods (October–November 1993 and May–June 1994). Rectal swabs were obtained weekly from admission to discharge the ICU. Overall, 77 (41%) had A. fecal colonization; detected 55(71%) of within first week their ICU stay. Clinical infections due occurred more frequently than those without (26% vs. S%, respectively; P < .001). The...
From March 1995 to 1997, sulbactam was prospectively evaluated in patients with non-life-threatening multiresistant Acinetobacter baumannii infections. During this period, 47 were treated sulbactam; of them, five excluded because they had received < or =48 h therapy. A total 42 patients, 27 males and 15 females a mean age 60+/-15 years, finally evaluated. Infections as follows: surgical wound, 19; tracheobronchitis, 12; urinary tract, 7; catheter-related bacteraemia, 2; pneumonia, 2....
ABSTRACT The treatment of life-threatening infections due to carbapenem-resistant Acinetobacter baumannii has become a serious challenge for physicians worldwide. Often, only colistin shows in general good vitro activity against these strains, but its antibacterial efficacy comparison with the antibiotics most used clinical practice is not well known. We studied versus those imipenem, sulbactam, tobramycin, and rifampin an experimental pneumonia model immunocompetent mice. three strains A....
Multidrug-resistant Streptococcus pneumoniae isolates of serotype 19A have emerged all over the world in recent years. The aim this study was to characterize highly penicillin-resistant pneumococcal strains serotype, collected Spain from 1997 2007 patients with invasive disease. Antibiotic susceptibility studied by microdilution. All pneumococci were typed PFGE and selected multilocus sequence typing (MLST). presence genes related Tn916 family transposons investigated PCR. From a total 1197...
Current information regarding bloodstream infection (BSI) in patients with solid tumors is scarce. We assessed the epidemiology, antibiotic therapy, and outcomes of BSI these patients. also compared who died those survived to identify risk factors associated mortality. From January 2006 July 2012 all episodes at a cancer center were prospectively recorded analyzed. A total 528 documented 489 The most frequent neoplasms hepatobiliary (19%), followed by lung (18%) lower gastrointestinal...
Auranofin is an FDA-approved, gold-containing compound in clinical use for the oral treatment of rheumatoid arthritis and has been recently granted by regulatory authorities due to its antiprotozoal properties.A reprofiling strategy was performed with a Streptococcus pneumoniae phenotypic screen proprietary library compounds, consisting both FDA-approved unapproved bioactive compounds. Two different multiresistant S. strains were employed sepsis mouse model infection. In addition, MRSA...
The prevalence of a new hypervirulent and hypermucoviscous K. pneumoniae phenotype (Hmv) is increasing worldwide, mainly linked to serotypes K1 K2. Since capsular thickness can directly affect the capability form biofilms, we aimed evaluate association between Hmv with adhesion biofilm formation in collection clinical isolates. We selected 38 isolates [15 serotype K1; 9 K2; 3 non-K1/K2 (rmpA+); 11 (rmpA-)] 7 non-Hmv was assessed through mucoviscosity test. Serum resistance determined by...
The increase in erythromycin resistance among Streptococcus pyogenes isolates is a cause for concern. We analysed trends macrolide resistance, phenotypes, genotypes, determinants and transposons erythromycin-resistant S. collected from adults Barcelona hospital (1993–2008). Antibiotic susceptibility was studied by microdilution. Molecular typing performed PFGE, emm multilocus sequence (MLST). Macrolide genes those related to the Tn916 family of were detected PCR. Ninety-nine (18.3%) 541...
ObjectivesTo determine the prevalence of smoking and alcohol abuse among patients with invasive pneumococcal disease (IPD) in order to promote prevention strategies.MethodsWe prospectively studied all culture-proven IPD cases aged ≥18 years during period 1997–2011. The habits were evaluated. Pneumococcal serotyping was performed.ResultsThere 1378 cases, a mean age 61 ± 17 years; 65% males. Compared general population 18–64 years, same group more often current smokers (57% vs. 35%, p < 0.001)...