A5067259476- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Brucella: diagnosis, epidemiology, treatment
- Infectious Diseases and Tuberculosis
- Antibiotic Use and Resistance
- Orthopedic Infections and Treatments
- Otolaryngology and Infectious Diseases
- Clinical Nutrition and Gastroenterology
- Central Venous Catheters and Hemodialysis
- Urinary Tract Infections Management
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Emergency and Acute Care Studies
- Antifungal resistance and susceptibility
- Pancreatitis Pathology and Treatment
Bellvitge University Hospital
2015-2024
Universitat de Barcelona
2015-2024
Institut d'Investigació Biomédica de Bellvitge
2011-2024
Instituto de Salud Carlos III
2012-2024
Centre for Biomedical Network Research on Rare Diseases
2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2007-2020
Centro de Investigación Biomédica en Red
2019
Madrid Health Service
2015
Hospital Clínic de Barcelona
2014
Red Espanola de Investigacion en Patologia Infecciosa
2011
Penicillin-resistant strains of Streptococcus pneumoniae are now found worldwide, and with resistance to cephalosporin being reported. The appropriate antibiotic therapy for pneumococcal pneumonia due resistant remains controversial.
Background: oropharyngeal dysphagia is a common condition among the elderly but not systematically explored.
We retrospectively studied 24 adults with bacteremic pneumonia (25 episodes) due to penicillin-resistant pneumococci, for which the minimal inhibitory concentrations (MICs) of penicillin G were 0.12 8.0 micrograms per milliliter; 79 percent strains showed multiple antibiotic resistance. As compared 48 control patients caused by penicillin-sensitive pneumococci had a significantly higher incidence use beta-lactam antibiotics during previous three months (65 vs. 17 percent, P = 0.0008),...
Little is known about the epidemiology of invasive pneumococcal disease (IPD) after introduction 7-valent conjugate vaccine (PCV7) in Spain and other European countries.We performed a 10-year prospective study including all children with culture-proven IPD admitted to Sant Joan de Deu Hospital, children's center southern area Barcelona, Catalonia, Spain. PCV7 was introduced June 2001, current estimate coverage 45%-50%.Comparing prevaccine period (1997-2001) (2002-2006), among aged <2 years,...
ABSTRACT An outbreak due to extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-KP) was detected from May 1993 June 1995. A total of 145 patients, particularly patients in intensive care units (ICUs) (107 [72%]), were colonized or infected. Infection developed 92 (63%) and primary bacteremia caused by ESBL-KP the most frequent infection (40 [43%]). single clone identified pulsed-field gel electrophoresis analysis throughout whole period, no molecular epidemiological...
The emergence of pneumococci resistant to penicillin and other agents prompted us evaluate intravenous vancomycin for the therapy pneumococcal meningitis, which has an overall mortality 30%. Eleven consecutive adult patients with cerebrospinal fluid (CSF)-culture-proven meningitis positive initial CSF Gram stain were given (usual dosage, 7.5 mg/kg every 6 h 10 days). MBCs ranged from 0.25 0.5 micrograms/ml. Early adjunctive dexamethasone, mannitol, sodium phenytoin was also instituted. After...
From January 1979 to December 1990 we studied the susceptibility of 1,492 pneumococcal strains isolated from adult patients in Bellvitge Hospital, Barcelona, Spain, nine antimicrobial agents. Among clinically significant pneumococci, incidence penicillin-resistant increased 4.3% 40% 1990, and that erythromycin-resistant also rose 0% 9.4% 1990. On other hand, resistant tetracycline decreased 76.1% 37.6%, as did chloramphenicol-resistant strains, 56.5% 29.4%. The co-trimoxazole-resistant was...
The results of classic serological tests were compared with those enzyme-linked immunosor-bent assay in studies immunoglobulins to Brucella 761 serum samples from 75 patients brucellosis. Except for five instances involving the IgM ELISA, all gave positive at admission. Among 63 without relapse, rates persistent ELISA positivity (determined by Kaplan-Meier method) 12 months after therapy 25% IgM, 69% IgA, and 89% IgG. a second peak IgG IgA was often detected. persistence high antibody titers...
Objective: To compare the effectiveness of doxycycline-rifampin (DR) combination therapy with that classic doxycycline-streptomycin (DS) in patients brucellosis. Design: A randomized, double-blind study, a mean follow-up 15.7 months. Setting: 1000-bed teaching hospital Barcelona, Spain. Patients: Ninety-five (68 men and 27 women; age, 39 years) diagnosed brucellosis on basis both clinical serologic findings; 81 these had blood cultures positive for Brucella melitensis. Interventions:...
For 16 years we prospectively observed 530 adult patients with brucellosis to analyze the characteristics of and risk factors for relapse. Clinical laboratory findings from 86 relapsed were milder during relapse episode when compared those same initial disease. Blood cultures positive Brucella melitensis in 65% cases ∼80% Risk that identified as being independently associated (by logistic regression analysis) "less-effective" antibiotic therapy (OR, 8.3; 95% CI, 4.6–15.1), blood disease 2.7;...
Background. A dramatic decrease in the incidence of invasive pneumococcal disease (IPD) was observed among children and adults United States after introduction 7-valent conjugate vaccine (PCV7). Little is known about IPD PCV7 licensure Europe. The objective this study to examine changes prevalence era. Methods. We undertook a prospective involving with who required hospital admission southern area Barcelona, Spain. Three periods were studied: pre-PCV7 period (1997–2001), early (2002–2004),...
From 1988 to 1992, 27 of 855 cases Escherichia coli bacteremia in nonneutropenic adult patients observed at our hospital were due ciprofloxacin-resistant (CIPRO-R) strains. Eighteen episodes (67%) community acquired, and nine (33%) nosocomially acquired. Overall, the rates E. caused by CIPRO-R strains increased steadily from 0% 7.5% 1992 (P < 0.01). There was a statistically significant correlation between incidence upward trend fluoroquinolone (norfloxacin ciprofloxacin) use (r = 0.974;...
Journal Article Decreased susceptibility of penicillin-resistant pnenmococci to twenty-four βlactam antibiotics Get access J. Liñares, Liñares * aService Microbiology; Hospital de Bellvitge, Universidad BarcelonaBarcelona, Spain *Corresponding author Service Microbiology. Feixa Llarga a/n, 08907 Hospitalet Liobregat, Barcelona, Search for other works by this on: Oxford Academic PubMed Google Scholar T. Alonso, Alonso J.L. Pérez, Pérez Ayats, Ayats M.A. Dominguez, Dominguez R. Pallarés,...
Over a 5-yr period, from January 1985 to 1990, we prospectively studied 300 episodes of nosocomial pneumonia in 1,000-bed teaching hospital. All cases had an accurate bacteriologic diagnosis obtained by means highly reliable techniques. Legionella pneumophila caused total 36 episodes; 22 were endemic and 14 occurred during epidemic outbreak. No patient with been intubated before infection. To identify risk factors for L. pneumonia, compared the due 264 other bacteria. After adjusting...
The use of highly active antiretroviral therapy (HAART) may change the incidence of, and risk prognostic factors for, invasive pneumococcal disease in patients with human immunodeficiency virus (HIV).We prospectively studied 142 episodes bacteremia 122 HIV-infected adults. Eighty-five occurred pre-HAART era (1986-1996) 57 HAART (1997-2002). A case-control study was conducted to identify for era.The dropped from 24.1 per 1000 patient-years 8.2 (P = .01). Compared era, had more associated...