A5047782303- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- COVID-19 and healthcare impacts
- Vascular Malformations Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Brain Tumor Detection and Classification
- Cerebrovascular and Carotid Artery Diseases
- Spinal Fractures and Fixation Techniques
- Optical Imaging and Spectroscopy Techniques
- Head and Neck Surgical Oncology
- Moyamoya disease diagnosis and treatment
- CCD and CMOS Imaging Sensors
- Brain Metastases and Treatment
- Innovations in Medical Education
- Medical Imaging Techniques and Applications
- Traumatic Brain Injury Research
- Advanced Memory and Neural Computing
- Bat Biology and Ecology Studies
- Pituitary Gland Disorders and Treatments
Universidad Complutense de Madrid
2012-2025
Hospital Universitario 12 De Octubre
2007-2025
Research Institute Hospital 12 de Octubre
2008-2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
Centro de Investigación Biomédica en Red
2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
Hyperspectral imaging techniques (HSI) do not require contact with patients and are non-ionizing as well non-invasive. As a consequence, they have been extensively applied in the medical field. HSI is being combined machine learning (ML) processes to obtain models assist diagnosis. In particular, combination of these has proven be reliable aid differentiation healthy tumor tissue during brain surgery. ML algorithms such support vector (SVM), random forest (RF) convolutional neural networks...
Abstract Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain metastasis; however, its efficacy in preventing disease progression and associated toxicity have questioned clinical impact of this approach emphasized need alternative treatments. Given limited therapeutic options available these poor understanding molecular mechanisms underlying resistance metastatic lesions to WBRT, we sought uncover actionable targets biomarkers that could help refine patient...
The globally accepted surgical strategy in glioblastomas is removing the enhancing tumor. However, peritumoral region harbors infiltration areas responsible for future tumor recurrence. This study aimed to evaluate a predictive model that identifies of recurrence using voxel-based radiomics analysis magnetic resonance imaging (MRI) data. multi-institutional included retrospective patients diagnosed with glioblastoma who underwent surgery complete resection Fifty-five met selection criteria....
Object The aim of this study was to determine the incidence posttraumatic hydrocephalus in severely head-injured patients who required decompressive craniectomy (DC). Additional objectives were relationship between and several clinical radiological features, with special attention subdural hygromas as a sign distortion CSF circulation. Methods authors conducted retrospective 73 severe head injury DC. admitted authors' department January 2000 2006. Posttraumatic defined as: 1) modified...
Background: Since 1999, the Italian guidelines have been used at our department for management of patients with mild head injury (MHI). According to these guidelines, a computed tomography (CT) scan should be obtained in all coagulopathy and routinely undergo strict observation during first 24 hours after injury; addition they control CT before discharge. With increased use anticoagulant therapy elderly population, admitting such treatment MHI emergency rooms has become very common. The aim...
A high percentage of patients with brain metastases frequently develop neurocognitive symptoms; however, understanding how metastasis co-opts the function neuronal circuits beyond a tumor mass effect remains unknown. We report comprehensive multidimensional modeling functional analyses in context metastasis. By testing different preclinical models from various primary sources and oncogenic profiles, we dissociated heterogeneous impact on local field potential oscillatory activity cortical...
There were two main purposes to this study: first, assess the feasibility and reliability of 2 quantitative methods bleeding volume in patients who suffered spontaneous subarachnoid hemorrhage (SAH), second, compare these other qualitative semiquantitative scales terms accuracy predicting delayed cerebral ischemia (DCI) outcome.A prospective series 150 consecutively admitted Hospital 12 de Octubre over a 4-year period included study. All had diagnosis SAH, diagnostic CT was able be performed...
Traumatic brain injury (TBI) represents a large health and economic burden. Because of the inability previous randomized controlled trials (RCTs) on TBI to demonstrate expected benefit reducing unfavorable outcomes, IMPACT (International Mission Prognosis Analysis Clinical Trials in TBI) CRASH (Corticosteroid Randomisation After Significant Head Injury) studies provided new methods for performing prognostic TBI. This study aimed develop externally validate model early death (within 48...
Cytomegalovirus (CMV) pneumonia is one of the most common pulmonary complications after bone marrow transplantation (BMT). We describe high resolution CT (HRCT) findings 13 patients with CMV diagnosed allogenic BMT. The study included consecutive who developed BMT and had HRCT chest performed within 24 h onset symptoms. scans were reviewed by two radiologists assessed pattern distribution findings. There nine male four female patients, ranging from 9 years to 56 age (mean 33 years). was for...
Abstract BACKGROUND Despite some evidence for the adoption of endoscopic transnasal trans-sphenoidal surgery (ETSS) pituitary adenomas, advantages this technique over traditional approach have not been robustly confirmed. OBJECTIVE To compare ETSS with microscopic sublabial trans-septal (MTSS) adenomas. METHODS We retrospectively reviewed 2 cohorts and MTSS performed at our institution from 1995 to 2017. Patient characteristics, surgical data, outcomes were recorded prospectively. a...
Background: Glioblastoma (GB) is a highly aggressive cancer with nearly 100% recurrence, even after removal of all contrast-enhancing (CE) disease. This primarily due to the persistence residual tumor cells in peritumoral brain zone (PBZ), which can repopulate GB treatment. The aim this study was characterize degree neoplastic infiltration and microenvironment (TME) periphery these tumors. Methods: We generated prospective collection radiologically guided biopsies from patients where we...
Quantitative estimation of the hemorrhage volume associated with aneurysm rupture is a new tool assessing prognosis.To determine prognostic value quantitative amount bleeding after aneurysmal subarachnoid hemorrhage, as well relative importance this factor related to other indicators, and establish possible cut-off poor outcome.A prospective cohort 206 patients consecutively admitted diagnosis Hospital 12 de Octubre were included in study. Subarachnoid, intraventricular, intracerebral, total...
Radiomics, in combination with artificial intelligence, has emerged as a powerful tool for the development of predictive models neuro-oncology. Our study aims to find an answer clinically relevant question: is there radiomic profile that can identify glioblastoma (GBM) patients short-term survival after complete tumor resection? A retrospective GBM who underwent surgery was conducted two institutions between January 2019 and 2020, along cases from public databases. Cases gross total or near...
Intracranial pressure (ICP) monitoring is recommended for patients with traumatic brain injury (TBI) a Glasgow Coma Scale (GCS) <9 on admission and revealing space-occupying lesions or swelling computed tomography. However, previous studies that have evaluated its effect outcome shown conflicting results.To study the of ICP after adjustment patient's characteristics imbalance determine potential benefit higher GCS deteriorates early in absence tomography results suggesting high ICP.We...
Glioblastoma IDH wild type (GBM wt) has a poor prognosis and strongly associated with inflammatory processes. Inflammatory molecules generate positive feedback tumor cells fueling growth as well recruitment of immune that promote aggressiveness. Although the role many is known, there are macromolecules, such S100A proteins, whose only now beginning to be established.
To describe the surgical and ultrastructural findings in trigeminal root of a patient with neuralgia (TN) associated cerebellopontine epidermoid tumor, to relate these literature reports patients vascular compression-related TN.A 39-year-old woman presented right TN. She had 10-year history lancinating pain paroxysms second third branches. Pain exhibited trigger areas improved partially carbamazepine. Cranial magnetic resonance imaging revealed an tumor angle that distorted compressed...