A5101568453- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Analytical Chemistry and Chromatography
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Analysis
- Hepatocellular Carcinoma Treatment and Prognosis
- Gestational Diabetes Research and Management
- Graphene and Nanomaterials Applications
- HER2/EGFR in Cancer Research
- Nanoparticles: synthesis and applications
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
The First Affiliated Hospital, Sun Yat-sen University
2014-2025
Shanghai Institute of Hematology
2019-2025
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Sun Yat-sen University
2014-2025
Shanghai Medical College of Fudan University
2005-2024
Jilin University
2019-2024
Beijing University of Chinese Medicine
2009-2024
Anhui Academy of Agricultural Sciences
2024
Songjiang District Central Hospital
2024
We compared the increases in prevalence of gestational diabetes mellitus (GDM) based on 1999 World Health Organization (WHO) criteria and its risk factors Tianjin, China, over a 12-year period. also examined changes using International Association Diabetes Pregnancy Study Group (IADPSG).In 2010-2012, 18589 women who registered within 12 weeks gestation underwent glucose challenge test (GCT) at 24-28 weeks. Amongst them, 2953 with 1-hour plasma ≥ 7.8 mmol/L 75-gram 2-hour oral tolerance...
Irritable bowel syndrome (IBS) is a highly prevalent chronic functional gastrointestinal disorder. Recent studies have showed increasing important role of gut microbiota in the pathophysiological changes IBS. Our study aims to elaborate association between intestinal flora with genesis and development IBS.Illumina high-throughput sequencing technology was applied investigate microbial communities IBS patients healthy donors. Stool specimens from IBS-D were equally premixed implanted into...
The underlining mechanisms of dietary cholesterol and nonalcoholic steatohepatitis (NASH) in contributing to hepatocellular carcinoma (HCC) remain undefined. Here we demonstrated that high-fat-non-cholesterol-fed mice developed simple steatosis, whilst high-fat-high-cholesterol-fed NASH. Moreover, induced larger more numerous NASH-HCCs than non-cholesterol-induced steatosis-HCCs diethylnitrosamine-treated mice. displayed significantly aberrant gene expression-enriched signaling pathways...
Tumor-associated macrophages (TAMs), the most abundant infiltrating immune cells in tumor microenvironment, have distinct functions hepatocellular carcinoma (HCC) progression. CD68+ TAMs represent multiple polarized mainly containing CD86+ antitumoral M1 and CD206+ protumoral M2 macrophages. expression density were assessed by immunohistochemical staining of CD68, CD86, CD206 tissue microarrays from 253 HCC patients. Clinicopathologic features prognostic value these markers evaluated. We...
Abstract Background Key hepatic molecules linking gut dysbiosis and hepatocarcinogenesis remain largely unknown. Gut-derived microbiota contains pathogen-associated molecular patterns (PAMPs) that may circulate into the liver and, consequently, be recognized by pattern recognition receptors (PRRs). NOD2, a general intracellular PRR, recognizes muramyl dipeptide (MDP), present in both gram (+) (−) bacteria. Here, we investigated role of NOD2 as sensor translating signaling...
Background and Aims: Liver fibrosis is a leading indicator for increased mortality long-term comorbidity in NASH. Activation of HSCs excessive extracellular matrix production are the hallmarks liver fibrogenesis. Tyrosine kinase receptor (TrkB) multifunctional that participates neurodegenerative disorders. However, paucity literature available about TrkB function fibrosis. Herein, regulatory network therapeutic potential were explored progression hepatic Methods Results: The protein level...
Background Hepatocellular carcinoma (HCC) is an exceptionally immunosuppressive malignancy characterized by limited treatment options and a dismal prognosis. Macrophages constitute the primary heterogeneous immune cell population within HCC microenvironment. Our objective to identify distinct subsets of macrophages implicated in progression their resistance immunotherapy. Methods Intratumoral macrophage-specific marker genes were identified via single-cell RNA sequencing analyses. The...
Abstract Gastric cancer remains a leading cause of cancer-related death worldwide, largely due to inadequate screening methods, late diagnosis, and limited treatment options. Liquid biopsy has emerged as promising non-invasive approach for prognosis by detecting circulating tumor components like DNA (ctDNA) in the blood. Numerous gastric cancer-specific ctDNA biomarkers have now been identified. CtDNA analysis provides insight into genetic epigenetic alterations tumors, holding promise...
The effects of L1-Fc and CHL1-Fc fusion proteins on neuronal survival were investigated. Cerebellar granule neurons mouse hippocampal rat embryo undergo apoptosis when cultured in serum-free medium. Treatment with chimeric containing the extracellular domains neural adhesion molecules L1 or CHL1 fused to Fc region human immunoglobulin significantly enhanced neurons. Compared control, percentage surviving increased about 60% 45% proteins, respectively. A protein domain NCAM had no effect...
Abstract Solid‐phase microextraction (SPME) followed by gas chromatography/mass spectrometry (GC/MS) was used for the detection of liver cancer volatile biomarkers. Headspace SPME conditions (fiber coating, extraction temperature and time) desorption were optimized applied to determination volatiles in human blood. Between group (n = 19) normal 18), positive rates 19 compounds among total 47 detected found be different with statistical significance ( p < 0.05, chi‐squared test). We...
The hepatotoxicity of two types multi-walled carbon nanotubes (MWCNTs), acid-oxidized MWCNTs (O-MWCNTs) and Tween-80-dispersed (T-MWCNTs), were investigated with Kunming mice exposed to 10 60 mg kg(-1) by intravenous injection for 15 d. Compared the PBS group, body-weight gain decreased level total bilirubin aspartate aminotransferase increased in MWCNT-exposed group a significant dose-effect relationship, while tumor necrosis factor alpha did not show statistical change within Spotty...
Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput and rapid advances our understanding the genetic bases human diseases. Today, NGS method dominated space research, quickly entered clinical practice. Because unique features perfectly meet reality (need to do more with less), technology is becoming a driving force realize dream precision medicine. This article describes strengths NGS, panels used medicine, current applications...
There are no randomised controlled trials to demonstrate whether lifestyle modifications can improve pregnancy outcomes of gestational diabetes mellitus (GDM) diagnosed by the International Association Diabetes and Pregnancy Study Group's (IADPSG) criteria. We tested effectiveness implemented in a 3-tier's shared care (SC) on GDM.
As a consumer product, black chokeberry (Aronia melanocarpa) is difficult to consume due its pungent taste. It mainly used in various food industries produce variety of juices, preserves, extracts, fruit teas and nutritional supplements. Traditionally, Potawatomi Native Americans treat colds, coughs fever. has been found contain numerous active ingredients. Currently, there are many health medical products that chokeberry. The purpose this review understand the benefits explore beneficial...
Lipid metabolism reprogramming is a recognized hallmark of cancer cells. Identification the underlying regulators metabolic in esophageal squamous cell carcinoma (ESCC) could uncover potential therapeutic targets to improve treatment. Here, we demonstrated that pre-mRNA processing factor 19 (PRP19) mediates lipid ESCC. Expression PRP19 was significantly upregulated multiple ESCC cohorts and correlated with poor clinical prognosis. promoted proliferation vitro vivo. Upregulation enhanced...