A5102905100- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hippo pathway signaling and YAP/TAZ
- Sirtuins and Resveratrol in Medicine
- Genomics and Phylogenetic Studies
- Glycosylation and Glycoproteins Research
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Cervical Cancer and HPV Research
- Liver physiology and pathology
- RNA regulation and disease
- Calcium signaling and nucleotide metabolism
- Genomics, phytochemicals, and oxidative stress
- Plant Toxicity and Pharmacological Properties
- Folate and B Vitamins Research
- Global Cancer Incidence and Screening
- Endoplasmic Reticulum Stress and Disease
- Liver Disease and Transplantation
- Flavonoids in Medical Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Endometrial and Cervical Cancer Treatments
- Lipid metabolism and biosynthesis
- Cancer, Hypoxia, and Metabolism
Zhongshan Hospital
2021-2025
Fudan University
2021-2025
Sun Yat-sen University
2021-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2025
Shanghai Institute of Hematology
2021-2024
Henan University
2023
Shanghai Tenth People's Hospital
2018
Tongji University
2018
Background and Aims: Liver fibrosis is a leading indicator for increased mortality long-term comorbidity in NASH. Activation of HSCs excessive extracellular matrix production are the hallmarks liver fibrogenesis. Tyrosine kinase receptor (TrkB) multifunctional that participates neurodegenerative disorders. However, paucity literature available about TrkB function fibrosis. Herein, regulatory network therapeutic potential were explored progression hepatic Methods Results: The protein level...
Pancreatic cancer is a common malignant tumor with high incidence and mortality rate. The prognosis of patients pancreatic considerably poor due to the lack effective treatment in clinically. Despite numerous studies have revealed that baicalein, natural product, responsible for suppressing multiple cells proliferation, motility invasion. mechanism by which baicalein restraining progression remains unclear. In this study, we firstly verified plays critical role inhibiting tumorigenesis vitro...
ABSTRACT Macrophages play critical roles in wound healing process. They switch from “classically activated” (M1) phenotype the early inflammatory phase to “alternatively (M2) later phase. However, dynamic process of macrophage switching diabetic wounds burdened with bacteria is unclear. In this report, Pseudomonas aeruginosa , frequently detected foot ulcers, was inoculated into cutaneous db/db mice mimic bacterium‐infected healing. We observed that P. infection impaired and quickly promoted...
Hepatocellular carcinoma (HCC) as a main type of primary liver cancers has become one the most deadly tumors because its high morbidity and poor prognosis. Fucoidan is family natural, heparin-like sulfated polysaccharides extracted from brown algae. It not only widely used dietary supplement, but also participates in many biological activities, such anti-oxidation, anti-inflammation anti-tumor. However, mechanism fucoidan induced inhibition HCC elusive. In our study, we demonstrated that...
Hepatoblastoma (HB) is the most common malignant liver tumor in children, with limited treatment options. The N4-acetylcytidine (ac4C) modification, an important mRNA post-transcriptional modification catalyzed by N-acetyltransferase 10 (NAT10), plays a crucial role initiation and progression of tumors. However, its impact on development prognosis HB largely unknown. This study demonstrates that NAT10 notably upregulated HB. inhibition suppressed proliferation metastasis vitro vivo....
Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related mortality worldwide. Ferroptosis, an iron‐dependent form programmed cell death driven by lipid peroxidation, has emerged as promising strategy for cancer treatment. However, the development ferroptosis resistance limits efficacy such treatments. This study reports that phosphatidylinositol 4‐phosphate 5‐kinase 1 alpha (PIP5K1A) promotes HCC tumorigenesis and predicts poor prognosis in patients. Knockdown PIP5K1A...
Cancer stem cells (CSCs) are considered to play a key role in the development and progression of pancreatic ductal adenocarcinoma (PDAC). However, little is known about lipid metabolism reprogramming PDAC CSCs. Here, we assigned stemness indices, which were used describe quantify CSCs, every patient from Genome Atlas (TCGA-PAAD) database observed differences between patients with high low indices. Then, tumor-repopulating (TRCs) cultured soft 3D (three-dimensional) fibrin gels demonstrated...
Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly lethal malignancy that currently lacks effective clinical treatments. Eliminating stem cell‐like cancer cells an extremely promising but challenging strategy for treating ICC. A recently developed synthetic retinoid, sulfarotene, abrogates proliferation, and induces apoptosis of tumor‐repopulating (TRCs) exhibit properties, yet its effect underlying mechanisms remain elusive in It found although 5‐fluorouracil, cisplatin,...
Non-small cell lung cancer (NSCLC) has the highest morbidity and mortality among all carcinomas. However, it is difficult to diagnose in early stage, current therapeutic efficacy not ideal. Although numerous studies have revealed that Ailanthone (Aila), a natural product, can inhibit multiple cancers by reducing proliferation invasion inducing apoptosis, mechanism which Aila represses NSCLC progression time-dependent manner remains unclear. In this study, we observed most long noncoding RNAs...
The present study aimed to investigate healthcare professionals' perceptions and experiences in caring for cervical cancer patients. was also designed assess the attitudes toward screening its prevention.A cross-sectional quantitative descriptive conducted, 540 participants (240 nurses 300 doctors), from different hospitals of Pakistan have been selected interviewed.Data collected using structured questionnaires SPSS used statistically analyze data. Participants are questioned with respect...
Background and AimsPyrrolizidine alkaloids (PAs), widely distributed in plants, are known to induce liver failure. Hepatic platelet accumulation has been reported during the progression of PA-induced injury (PA-ILI). This study aimed investigate mechanisms underlying PA-ILI.